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Publikováno v:
Breast Cancer Research : BCR
Introduction Proteasome inhibition provides an attractive approach to cancer therapy and may have application in the treatment of breast cancer. However, results of recent clinical trials to evaluate the effect of the proteasome inhibitor Bortezomib
Autor:
Reik Löser, Larissa J. Vos, Sai Kiran Sharma, John R. Mackey, Monica Wang, Ingrit Hamann, Frank Wuest, Manuela Kuchar, Melinda Wuest, Susan Richter
Publikováno v:
Breast Cancer Research 17(2015), 107
Breast Cancer Research : BCR
Breast Cancer Research : BCR
Introduction: Lysyl oxidase (LOX; ExPASy ENZYME entry: EC 1.4.3.13) and members of the LOX-like family, LOXL1–LOXL4, are copper-dependent enzymes that can modify proteins of the extracellular matrix. Expression of LOX is elevated in many human canc
Publikováno v:
Breast Cancer Research : BCR
Introduction New signaling pathways of the interleukin (IL) family, interferons (IFN) and interferon regulatory factors (IRF) have recently been found within tumor microenvironments and in metastatic sites. Some of these cytokines stimulate while oth
Publikováno v:
Breast Cancer Research : BCR
Introduction Transducin (β)-like 1 X-linked receptor 1(TBLR1) is an F-box-like and WD repeat-containing protein which functions as a switch in transcriptional activation, However, the clinical significance and biological role of TBLR1 in breast canc
Autor:
Tejal Patel, Jenny C. Chang, Angel Rodriguez, Gerardo Colon-Otero, Edith A. Perez, Bhuvanesh Dave
Publikováno v:
Breast Cancer Research : BCR
The estrogen receptor and human epidermal growth factor receptor (HER) signaling pathways are the dominant drivers of cell proliferation and survival in the majority of human breast cancers. Not surprisingly, targeting these pathways provides the mos
Autor:
Kanji Nakatsu, Abdi Ghaffari, Maaike Hum, Navid Liaghati, Yolanda Madarnas, Victoria Hoskin, Alvin Szeto, Sandip SenGupta, Bruce E. Elliott, David P. LeBrun
Publikováno v:
Breast Cancer Research : BCR
Recent evidence suggests that tumour lymphangiogenesis promotes lymph node metastasis, a major prognostic factor for survival of breast cancer patients. However, signaling mechanisms involved in tumour-induced lymphangiogenesis remain poorly understo
Autor:
Thomas Kieber-Emmons, Ann Marie Kieber-Emmons, Eric R. Siegel, Bounleut Phanavanh, Soldano Ferrone, Fariba Jousheghany, Tina Gomes, Aiwei Yao-Borengasser, Behjatolah Monzavi-Karbassi, Larry J. Suva, Craig A. Cooney
Publikováno v:
Breast Cancer Research : BCR
Introduction We have previously demonstrated that chondroitin sulfate glycosaminoglycans (CS-GAGs) on breast cancer cells function as P-selectin ligands. This study was performed to identify the carrier proteoglycan (PG) and the sulfotransferase gene
Autor:
Jean-Simon Diallo, Dominic G. Roy, John C. Bell, Lauren Elizabeth St-Germain, Amelia Sadie Aitken, Theresa Falls, Vanessa Garcia, Rozanne Arulanandam, Marie-Claude Bourgeois-Daigneault, Adrian Pelin
Publikováno v:
Breast Cancer Research : BCR
Background Breast cancer is the most common malignant disease amongst Western women. The lack of treatment options for patients with chemotherapy-resistant or recurrent cancers is pushing the field toward the rapid development of novel therapies. The
Autor:
Alejandro Contreras, Lacey E. Dobrolecki, Susan G. Hilsenbeck, Meghana V. Trivedi, Ahmed Al-rawi, Sabrina Herrera, C. Kent Osborne, Chad J. Creighton, Raksha Bhat, Carolina Gutierrez, Mario Giuliano, Xiang Zhang, Sufeng Mao, Rachel Schiff, Pavel Christiny, Bianca Maria Veneziani, Michael T. Lewis, Tamika Mitchell, Mothaffar F. Rimawi, Fengju Chen, Xiaomei Zhang, Chad A. Shaw, Rinath Jeselsohn
Publikováno v:
Breast Cancer Research : BCR
Introduction Real-time monitoring of biologic changes in tumors may be possible by investigating the transitional cells such as circulating tumor cells (CTCs) and disseminated tumor cells in bone marrow (BM-DTCs). However, the small numbers of CTCs a
Autor:
Jhih Rong Lin, Wen Zhang, Rubén Nogales-Cadenas, Zhengdong D. Zhang, Ying Cai, Cristina Montagna, Quanwei Zhang
Publikováno v:
Breast Cancer Research : BCR
Background MicroRNAs (miRNAs) are small non-coding RNA molecules of about 22 nucleotides which function to silence the expression of their target genes. Numerous studies have shown that miRNAs are not only key regulators in important cellular process