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Publikováno v:
Breast Cancer Research
Background Viruses including Epstein–Barr virus (EBV), a human equivalent of murine mammary tumour virus (MMTV) and human papillomavirus (HPV) have been implicated in the aetiology of human breast cancer. We report the presence of HPV DNA sequences
Autor:
Mario Giuliano, Emilia Montagna, Diego D'Agostino, Sabino De Placido, Giuseppe Cancello, Monica Plaitano, Giuseppe Di Lorenzo, Michele De Laurentiis, Antonio Giordano
Publikováno v:
Breast Cancer Research : BCR
INTRODUCTION: We performed a retrospective analysis of HER2-overexpressing metastatic breast cancer patients to describe clinical outcomes of those who, despite progression of the disease (PD), maintained trastuzumab for multiple chemotherapy lines.
Publikováno v:
Breast Cancer Research : BCR
Introduction Characterizing and differentiating between malignant tumors, benign tumors, and normal breast tissue is increasingly important in the patient presenting with breast problems. Near-infrared diffuse optical imaging and spectroscopy is capa
Autor:
Rochelle E. Curtis, Mark M. Huycke, Bassam Ghabach, William F. Anderson, Jackie A. Lavigne, Graça M. Dores
Publikováno v:
Breast Cancer Research : BCR
Introduction Adenoid cystic carcinoma of the breast (breast-ACC) is a rare and special type of basal-like tumor for which scant population-based descriptive data exist. We sought to provide new population-based information on breast-ACC incidence, re
Autor:
Janet R. Daling, Danielle M. Friedrichsen, Elaine A. Ostrander, Kathleen E. Malone, David R. Doody
Publikováno v:
Breast Cancer Research
Introduction The cell-cycle checkpoint kinase (CHEK)2 protein truncating mutation 1100delC has been associated with increased risk for breast or prostate cancer. Multiple studies have found an elevated frequency of the 1100delC variant in specific st
Autor:
Sophia Agelaki, Antonia Kalykaki, A. Xyrafas, Emmanouil Saloustros, Kostas Kalbakis, Galatea Kallergi, Dimitris Mavroudis, Stella Apostolaki, M. Perraki, Vassilis Georgoulias
Publikováno v:
Breast Cancer Research : BCR
Background The detection of cytokeratin-19 (CK-19) mRNA-positive circulating tumor cells (CTC) before and/or after adjuvant chemotherapy in patients with operable breast cancer is associated with poor clinical outcome. Reliable prognostic markers for
Publikováno v:
Breast Cancer Research : BCR
Introduction Over the last decade several breast cancer risk alleles have been identified which has led to an increased interest in individualised risk prediction for clinical purposes. Methods We investigate the performance of an up-to-date 18 breas
Autor:
Anthony J. Swerdlow, Alan Ashworth, James Griffin, Emily McFadden, Minouk J. Schoemaker, Michael Jones, Lauren B. Wright
Publikováno v:
Breast Cancer Research : BCR
Background Women diagnosed with breast cancer frequently attribute their cancer to psychological stress, but scientific evidence is inconclusive. We investigated whether experienced frequency of stress and adverse life events affect subsequent breast
Publikováno v:
Breast cancer research : BCR
Background Stromal fibroblasts can contribute to tumor invasion through the release of matrix metalloproteinases (MMPs). Population studies have suggested that single nucleotide polymorphisms (SNPs) in MMP genes influence levels of expression and may
Publikováno v:
Breast Cancer Research : BCR
Background It is known that use of hormone replacement therapy (HRT) by postmenopausal women increases the risk of breast cancer. Method In this study, oestrogen receptor (ER)-α expression is examined using standard immunoperoxidase technique. Resul