Zobrazeno 1 - 10
of 20
pro vyhledávání: ''
Autor:
John R. Mackey, Anil A. Joy
Publikováno v:
Breast Cancer Online. 9:1-7
Trastuzumab is a monoclonal antibody targeting the human epidermal growth factor receptor-2 (HER-2) protein, the mediator of an aggressive breast cancer phenotype. Trastuzumab has an important role in the treatment of metastatic breast cancer (MBC) w
Autor:
I. E. Smith, R. L. Jones
Publikováno v:
Breast Cancer Online. 9:1-3
Publikováno v:
Breast Cancer Online. 9:1-3
Autor:
F. O. Ademuyiwa, G. W. Sledge
Publikováno v:
Breast Cancer Online. 12
Angiogenesis, or new vessel formation, plays a key role in the process of tumor growth and metastasis in breast cancer. Recent large phase-III trials (E2100 and AVADO) demonstrate the clinical utility of bevacizumab in combination with front-line tax
Autor:
Sherene Loi
Publikováno v:
Breast Cancer Online. 11
Citation of original article:Koket al.Breast Cancer Research and Treatment4 March 2008 [Epub ahead of print].Abstract of the original article:Background:Molecular signatures that predict outcome in tamoxifen-treated breast cancer patients have been i
Autor:
A. H. G. Paterson
Publikováno v:
Breast Cancer Online. 11
Bisphosphonates offer a potentially effective adjuvant therapy to reduce recurrence of bone metastases in breast cancer patients. Clinical trials are at the early stage, but initial results have shown promise. There are three published adjuvant trial
Autor:
Alison J. Butt
Publikováno v:
Breast Cancer Online. 11
Citation of original article:C. Lagadec, E. Adriaenssens, R. A. Toillon, V. Chopin, R. Romon, F. Van Coppenolle, H. Hondermarck, X. Le Bourhis. Oncogene advance online publication, 3 September 2007; doi:10.1038/sj.onc.1210749.Abstract of the original
Publikováno v:
Breast Cancer Online. 10
Most patients present with disease that appears to be confined to the breast. However, a significant proportion of women will go on to develop metastatic breast cancer with bone being the most frequent site of distant relapse. The bone microenvironme
Autor:
Arif H. Kamal, Matthew P. Goetz
Publikováno v:
Breast Cancer Online. 10
Tamoxifen can be considered a classic ‘pro-drug’, requiring metabolic activation to elicit pharmacological activity. Our findings suggest that both genetic and drug-induced factors that alter CYP2D6 enzyme activity influence the clinical response
Publikováno v:
Breast Cancer Online. 10
Treatment principles of breast cancer in males are derived from studies performed among females, while the low incidence in males has so far precluded such studies. The therapy recommendations for males therefore lack the solid evidence, frequently p