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Autor:
Takashi Suzuki, Minoru Miyashita, Ai Sato, Kiyoshi Takagi, Yasuhiro Miki, Mio Yamaguchi, Hironobu Sasano
Publikováno v:
Breast Cancer. 27:919-928
RAS-related C3 botulinus toxin substrate 1 (Rac1) is a molecular switch fluctuating between GDP-bound inactive form (Rac1-GDP) and GTP-bound active form (Rac1-GTP) and involved in diverse function in both normal and malignant cells such as breast car
Autor:
Satoshi Morita, Ryuji Uozumi, Fengling Pu, Kosuke Kawaguchi, Eiji Suzuki, Takeshi Kotake, Ayane Yamaguchi, Moe Tsuda, Masahiro Sugimoto, Mariko Nishie, Masakazu Toi
Publikováno v:
Breast Cancer. 26:282-289
It has been reported that the gene expression profile of peripheral blood mononuclear cells (PBMCs) exhibits a unique gene expression signature in several types of cancer. In this study, we aimed to explore the breast cancer patient-specific gene exp
Autor:
Junji Tsurutani, Kazuhiko Nakagawa, Kazuko Sakai, Hitomi Sakai, Tsutomu Iwasa, Kazuto Nishio, Yoshifumi Komoike
Publikováno v:
Breast Cancer (Tokyo, Japan)
Background Trastuzumab emtansine (T-DM1) is approved for the treatment of patients with human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer (ABC), and has high efficacy. However, some patients exhibit primary resistance to
Autor:
Masakazu Toi, Ayane Yamaguchi, Satoshi Morita, Michio Yamamoto, Kosuke Kawaguchi, Eiji Suzuki
Publikováno v:
Breast Cancer (Tokyo, Japan)
Background The purpose of this study was to clarify the alterations of major immune regulators in peripheral blood mononuclear cells (PBMCs) of cancer patients and to analyze the association with the disease progression in breast cancer patients. Met
Autor:
Shinji Yoshiyama, Hideaki Tokiniwa, Izumi Takeyoshi, Hiroki Odawara, Tetsunari Oyama, Miki Tsuboi, Susumu Rokudai, Reika Kawabata-Iwakawa, Masahiko Nishiyama, Arito Yamane, Takehiko Yokobori, Jun Horiguchi
Publikováno v:
Breast Cancer. 23:780-788
The members of AID/APOBEC protein family possess cytidine deaminase activity that converts cytidine residue to uridine on DNA and RNA. Recent studies have shown the possible influence of APOBEC3B (A3B) as DNA mutators of breast cancer genome. However
Autor:
Shinzaburo Noguchi, Kazuhiko Nakabayashi, Makio Shozu, Tsutomu Ogata, Junichi Suzuki, Ryo Tsunashima, Maki Fukami
Publikováno v:
Breast Cancer. 21:382-385
Increased intratumoral expression of aromatase, the key enzyme for estrogen biosynthesis, is predicted to be of critical importance in the development of breast cancer. Recently, several germline rearrangements at 15q21 have been shown to cause overe
Autor:
Kazuhiro Shimada, Daisuke Shimizu, Takashi Ishikawa, Takeshi Sasaki, Takashi Chishima, Yoshio Goshima, Yasushi Ichikawa, Fumio Nakamura, Yoji Nagashima, Itaru Endo
Publikováno v:
Breast Cancer. 21:715-723
Altered expression of collapsin response mediator proteins (CRMPs) has been reported in several malignant tumors, including downregulation of CRMP1 in lung cancer and upregulation of CRMP2 in colorectal cancer. This study aimed to investigate the rel
Autor:
Akihisa Saito, Junichi Motoshita, Seiichi Teramoto, Yoichi Tani, Toshinori Uike, Kazuya Kuraoka, Masato Koseki, Katsunari Ishida, Kiyomi Taniyama, Tamaki Toda
Publikováno v:
Breast Cancer. 15:231-240
Phosphorylated HER2 (pHER2) may more accurately reflect the signaling and functional activity of the HER2 protein than detection of HER2 itself. The detection of HER2 gene amplification using fluorescence in situ hybridization (FISH) provides superio
Publikováno v:
Breast Cancer. 10:301-306
Human X-box binding protein 1 (hXBP-1) is a transcription factor essential for hepatocyte growth as well as for plasma cell differentiation. hXBP-1 also binds to cis-elements of human T cell leukemia virus and human major histocompatibility complex g
Publikováno v:
Breast Cancer. 10:214-219
The integrin cell adhesion molecule (CAM) family is intimately involved in cell adhesion and invasion through tissue basement membranes (BM). As a consequence of the short survival of patient-derived human breast cancer cells, the invasion of such ce