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Autor:
Madoka Nakagomi, Sachiko Chikahisa, Mika Shimizu, Koichi Shudo, Kazuo Yoshizaki, Kazuyoshi Kitaoka, Hiroyoshi Sei, Noriyuki Shimizu
Publikováno v:
Brain Research. 1423:10-16
Vitamin A is a common lipophilic vitamin, and its function is mainly mediated by the binding of its metabolite retinoic acid to retinoic acid receptors (RARs) and retinoid X receptors. Recently, it was reported that the expression of the RARb (an RAR
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Acute stress has been shown to modify hypothalamus-pituitary-gonadal (HPG) axis activity. Corticotropin-releasing hormone (CRH), the principal regulator of the hypothalamus-pituitary-adrenal (HPA) axis, has been implicated as a mediator of stress-ind
Publikováno v:
Brain Research. 1422:13-19
Background: Endogenous β-endorphin (β-EP) in the central nervous system (CNS) is decreased upon opioid addiction. The current study examined whether exogenous β-EP, delivered using an adenoviral vector into the CNS could attenuate morphine withdra
Autor:
Ingeborg Løstegaard Goverud, Jon Lømo, Ragnhild E. Paulsen, Jan Mæhlen, Knut Liestøl, Petra Aden, Else Marit Løberg
Publikováno v:
Brain Research. 1418:32-41
Glucocorticoid (GC) treatment in premature infants may have detrimental effects on the immature brain. Here we show that GCs dexamethasone (Dex) and hydrocortisone (HC) reduce proliferation and induce differentiation of chicken embryo cerebellar neur
Autor:
Jacqueline Sagen, Aldric Hama
Publikováno v:
Brain Research. 1412:44-54
Activation of CNS cannabinoid subtype-1 (CB1) receptors has been shown to mediate the antinociceptive and other effects of systemically administered CB receptor agonists. The endogenous peptide CB receptor ligand hemopressin (HE) has previously demon
Publikováno v:
Brain Research. 1414:10-21
Although up-regulation of β-adrenergic receptors (β-ARs) occurs after long-term use of their antagonists in various tissues, the available data are little on mechanisms of β-AR up-regulation induced by their continuous blockade. The present study
Publikováno v:
Brain Research. 1414:1-9
The mechanisms implicated in the sympathoexcitation and pressor the response elicited by central CB1R activation are not fully understood. Further, the few reported mechanistic studies on this endeavor were conducted in anesthetized rats. Therefore,
Publikováno v:
Brain Research. 1407:62-68
Nitric oxide (NO), a potent vasodilator and nontraditional neurotransmitter, is an important mediator of the changes in cerebral blood flow (CBF) associated with increased neuronal activity (neurovascular coupling). In the present work, we investigat
Publikováno v:
Brain Research. 1407:90-96
We characterized the effect of acute ischemic stroke on the activation of the hypothalamic-pituitary-adrenal (HPA) axis and evaluated the role of glucocorticoids (GC) in the clinical outcome following ischemic stroke. Male spontaneous hypertensive ra
Publikováno v:
Brain Research. 1406:1-7
Neuropathic pain is a debilitating condition that is often difficult to treat using conventional pharmacological interventions and the exact mechanisms involved in the establishment and maintenance of this type of chronic pain have yet to be fully el