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pro vyhledávání: ''
Autor:
Ai-Mei Liao, Zi-Shan Zhang, Long Pan, Yong-Jian Yuan, Guanghai Yu, Jian Cao, Cui-Zhu Tian, Huang Jihong, Ming Hui, Yu-Qi Dong, Shuai-Nan Zheng, Wen-Jin Lin, Yin-Chen Hou, Xiaoxiao Li, Zeng-Liang Liu
Publikováno v:
Brain Research. 1773:147672
Wheat embryo globulin nutrient (WEGN), with wheat embryo globulin (WEG) as the main functional component, is a nutritional combination that specifically targets memory impairment. In this study, we explored the protective role of WEGN on Alzheimer's
Publikováno v:
Brain Research. 1670:14-23
Leptomycin B (LMB), originally developed as an anti-fungal agent, has potent neuroprotective properties against status epilepticus (SE, a prolonged seizure activity). However, the pharmacological profiles and mechanisms of LMB for neuroprotection rem
Autor:
Teng-yue Zhang, Jing-jun Zheng, Zhao-Rui Wang, Mei Zhang, Xu Qian, Wei Li, Ji-qiang Ding, Jia-gui Zhong
Publikováno v:
Brain research. 1714
Temporal lobe epilepsy (TLE) is a chronic neurological disorder that is a refractory disease. Baicalein possesses various pharmacological activities, including neuroprotection in neurodegenerative disease. However, whether baicalein is protective in
Publikováno v:
Brain Research. 1642:238-243
Little is known about the mechanisms of unconsciousness induced by general anesthetics. Previous studies have shown that the primary somatosensory cortex (S1) is a sensitive region to a variety of intravenous general anesthetics. Etomidate is a widel
Autor:
Nan Li, Lie Yu, Di Zhang, Xiaojie Fu, Jiang Man, Zhengfang Lu, Kefei Cui, Jianping Wang, Yufeng Gao
Publikováno v:
Brain research. 1736
Donepezil, a selective acetylcholinesterase (AchE) inhibitor, enhances stroke-induced neurogenesis within subventricular zone (SVZ). Src/Pyk-2 is one of the downstream pathways of acetylcholine receptors (AchRs), and has been shown to participate in
Autor:
Jin Hee Kim, Hui Chul Choi, Song Hee Lee, Hong Ki Song, Bo Young Choi, Sang Won Suh, Dong Won Lee, Min Sohn
Publikováno v:
Brain Research. 1595:156-165
Citicoline (CDP-choline; cytidine 5'-diphosphocholine) is an important intermediate in the biosynthesis of cell membrane phospholipids. Citicoline serves as a choline donor in the biosynthetic pathways of acetylcholine and neuronal membrane phospholi
Publikováno v:
Brain Research. 1554:12-20
Extracellular acidosis is a common feature in pain-generating pathological conditions. Acid-sensing ion channels (ASICs), pH sensors, are distributed in peripheral sensory neurons and participate in nociception. Morphine exerts potent analgesic effec
Publikováno v:
Brain research. 1657
The pathogenesis of Alzheimer's disease (AD) is well documented to involve mitochondrial dysfunction which causes subsequent oxidative stress and energy metabolic failure in hippocampus. Methylene blue (MB) has been implicated to be neuroprotective i
Autor:
Xiu Ying Wu, Wei Min Chen, Long Chang Fan, Qiang Li, Dong Yi Tong, Ping Zhao, Limin Zhang, Ping An, Xiao Chun Zhao, Jian Wang
Publikováno v:
Brain Research. 1537:283-289
Different mechanisms have been suggested to contribute to isoflurane-mediated neuroprotection. Previous studies have suggested that the protein Slit can abrogate neuronal death in mixed neuronal-glial cultures exposed to oxygen-glucose deprivation (O
Autor:
Arshad Majid, Ok-Nam Bae
Publikováno v:
Brain Research. 1527:246-254
Urgent need exists for new therapeutic options in ischemic stroke. We recently demonstrated that carnosine, an endogenous dipeptide consisting of alanine and histidine, is robustly neuroprotective in ischemic brain injury and has a wide clinically re