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Autor:
Larissa A. Roslavtseva, Ilya D. Ionov
Publikováno v:
Brain Research. 1451:27-33
Motor neurons (MNs) of an adult rat are normally insensitive to the neurotoxic action of NMDA. Meanwhile, the experiments in non-motor neurons showed that sensitivity to NMDA can be increased by bicuculline, an antagonist at GABA(A) receptors. The ai
Role of medullary GABA signal transduction on parasympathetic reflex vasodilatation in the lower lip
Publikováno v:
Brain Research. 1437:26-37
In the orofacial area, noxious stimulation of the orofacial structure in the trigeminal region evokes parasympathetic reflex vasodilatation, which occurs via the trigeminal spinal nucleus (Vsp) and the inferior/superior salivatory nucleus (ISN/SSN).
Publikováno v:
Brain Research. 1426:18-29
Applying emetine, a protein synthesis inhibitor, at 20–40 μM for 90–120 min prior to LTP induction in hippocampal slices from young rats (2–3 weeks) and washing it out afterwards revealed a slowly developing potentiation that reached maximum a
Autor:
Ingeborg Løstegaard Goverud, Jon Lømo, Ragnhild E. Paulsen, Jan Mæhlen, Knut Liestøl, Petra Aden, Else Marit Løberg
Publikováno v:
Brain Research. 1418:32-41
Glucocorticoid (GC) treatment in premature infants may have detrimental effects on the immature brain. Here we show that GCs dexamethasone (Dex) and hydrocortisone (HC) reduce proliferation and induce differentiation of chicken embryo cerebellar neur
Publikováno v:
Brain Research. 1407:62-68
Nitric oxide (NO), a potent vasodilator and nontraditional neurotransmitter, is an important mediator of the changes in cerebral blood flow (CBF) associated with increased neuronal activity (neurovascular coupling). In the present work, we investigat
Publikováno v:
Brain Research. 1406:1-7
Neuropathic pain is a debilitating condition that is often difficult to treat using conventional pharmacological interventions and the exact mechanisms involved in the establishment and maintenance of this type of chronic pain have yet to be fully el
Autor:
Christian Pifl, Michael Freidl, Michael L. Berger, Franz Gabor, Johannes Winkler, Winfried Neuhaus, Phillip Szkokan, Christian R. Noe, Michael Wirth
Publikováno v:
Brain Research. 1394:49-61
Changes of the functionality of the blood-brain barrier (BBB) have been reported in the context of several brain related diseases such as multiple sclerosis, epilepsy, Alzheimer's disease and stroke. Several publications indicated the presence and fu
Publikováno v:
Brain Research. 1386:70-80
Our goal was to extend our understanding of the neural changes behind motor recovery with treadmill exercise in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mouse. We determined the extent of dopamine (DA) terminal changes using w
Publikováno v:
Brain Research. 1382:37-44
The presynaptic protein alpha-synuclein (α-syn) plays a role in dopaminergic neurotransmission in the nigrostriatal dopaminergic system. Mutations in this protein have been linked to pathogenesis of Parkinson's disease. However, the details of regul
Autor:
Cristina Ordóñez, Maria-Rosario Luquin, M. Manrique, Irene Marcilla, Javier Arbizu, J. Guillen
Publikováno v:
Brain Research. 1375:120-127
Striatal carotid body cell aggregates (CBCA) grafts improve parkinsonism in animals and patients with Parkinson's disease. As CB cells contain trophic factors, we investigated the long-term effect of striatal CBCA grafts on nigrostriatal dopaminergic