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Publikováno v:
Brain Research. 1659:148-155
Methamphetamine (METH) is a widely abused psychostimulant displaying potent addictive and neurotoxic properties. METH induces neurotoxicity of dopaminergic terminals and striatal neurons in the striatum. Despite much information on neurotransmitters,
Publikováno v:
Brain research. 1715
To investigate the mechanisms underlying the neuroprotective effect of tacrolimus (FK506) on the hippocampal neurons of rats with status epilepticus (SE).A total of 126 male Wistar rats were randomly and equally divided into the control group, the ep
Autor:
Teng-yue Zhang, Jing-jun Zheng, Zhao-Rui Wang, Mei Zhang, Xu Qian, Wei Li, Ji-qiang Ding, Jia-gui Zhong
Publikováno v:
Brain research. 1714
Temporal lobe epilepsy (TLE) is a chronic neurological disorder that is a refractory disease. Baicalein possesses various pharmacological activities, including neuroprotection in neurodegenerative disease. However, whether baicalein is protective in
Autor:
Carlos A. Mejias-Aponte
Publikováno v:
Brain Research. 1641:258-273
Dopamine (DA) is a neuromodulator that regulates different brain circuits involved in cognitive functions, motor coordination, and emotions. Dysregulation of DA is associated with many neurological and psychiatric disorders such as Parkinson's diseas
Publikováno v:
Brain Research. 1633:115-125
Parkinson's disease is a major neurodegenerative disorder which primarily involves the loss of dopaminergic neurons in the substantia nigra and related projections in the striatum. The pesticide/neurotoxin, rotenone, has been shown to cause systemic
Publikováno v:
Brain Research. 1625:218-237
Reciprocal interactions between nitrergic and dopaminergic systems play a key role in the control of motor behavior. In the present study, we performed a comparative analysis of motor behavior (locomotor activity, catalepsy, rotational behavior) and
Publikováno v:
Brain Research. 1624:78-85
3-O-demethylswertipunicoside (3-ODS) has been reported to protect dopaminergic neurons against neurotoxicity induced by 1-methyl-4-phenylpyridinium (MPP(+)) in PC12 cells. Here, we investigate the neuroprotective effects in vivo and antioxidant activ
Publikováno v:
Brain Research. 1734:146759
Dopamine is the predominant catecholamine neurotransmitter in the mammalian brain which has been shown to play a critical role in antinociceptive process. Previous studies have shown that the role of CA1 region of the hippocampus in antinociception i
Autor:
Jae-Im Kwon, Yoon-Seok Choi, Choong Gon Choi, Chul-Woong Woo, Dong-Cheol Woo, Ji-Yeon Suh, Jeong Kon Kim, Kyung Won Kim, Jin Seong Lee, Do-Wan Lee, Sang-Tae Kim, Dong-Hoon Lee
Publikováno v:
Brain research. 1717
Purpose To evaluate temporal changes in gamma-aminobutyric acid (GABA) signals in the hippocampus during epileptiform activity induced by kainic acid (KA) in a rat model of status epilepticus using chemical exchange saturation transfer (CEST) imaging
Autor:
Nan Li, Lie Yu, Di Zhang, Xiaojie Fu, Jiang Man, Zhengfang Lu, Kefei Cui, Jianping Wang, Yufeng Gao
Publikováno v:
Brain research. 1736
Donepezil, a selective acetylcholinesterase (AchE) inhibitor, enhances stroke-induced neurogenesis within subventricular zone (SVZ). Src/Pyk-2 is one of the downstream pathways of acetylcholine receptors (AchRs), and has been shown to participate in