Zobrazeno 1 - 10
of 102
pro vyhledávání: ''
Publikováno v:
Brain Research. 1592:1-10
The neurons of medial septal diagonal band of broca (MSDB) project to hippocampus and play an important role in MSDB-hippocampal synaptic transmission, plasticity and network oscillation. Nicotinic acetylcholine receptor (nAChR) subunits, α4β2 and
Publikováno v:
Brain Research. 1318:42-51
In the present study we used electrophysiological techniques in an in vitro preparation of the rat dentate gyrus to examine the effect of muscarinic acetylcholine receptor activation on the intrinsic excitability of hilar neurons. We found that bath
Publikováno v:
Brain Research. 1124:55-61
ATP-sensitive K (K(ATP)) channels, widely expressed in cytoplasmic membranes of neurons, couple cell metabolism to excitability. They are considered to play important roles in controlling seizure activity during hypoxia and in neuroprotection against
Autor:
Hans-Joachim Galla, José Luis Hernández Cáceres, Marc Häder, Ulrich Altrup, Michaela C. Meyer, Stefan Malcharek
Publikováno v:
Brain Research. 1122:65-77
Mechanisms of epileptiform activity in a model nervous system (buccal ganglia of Helix pomatia) are presented. The ganglia contain the identified giant neurons B1 through B4. For epileptiform activity, pentylenetetrazol (1 mmol/L to 40 mmol/L) or eto
Publikováno v:
Brain Research. 1118:66-74
GABA-A receptors mediate both phasic synaptic inhibition and more recently appreciated tonic currents in the vertebrate central nervous system. We addressed discrepancies in the literature regarding the pharmacology of tonic currents by examining ton
Autor:
Jin Ma, Li-Hong Long, Peng-Fei Wu, Lan Ni, Jian-Guo Chen, Zhuang-Li Hu, Jun Han, Hai Zhang, Fang Wang
Publikováno v:
Brain research. 1615
Dopamine, a key neurotransmitter mediating the rewarding effects, exerts some of its effects by modulating neuronal excitability of striatal medium spiny neurons. A D1-like dopamine receptor-dependent phosphatidylinositol signal pathway exists in the
Publikováno v:
Brain Research. 1057:81-87
We investigated the effects of histamine H1 antagonists on acutely dissociated neurons from the rat cortex using the patch-clamp technique. First-generation antihistamines, such as pyrilamine, d-chlorpheniramine, diphenhydramine, and ketotifen, suppr
Publikováno v:
Brain Research. 1033:58-67
The two neurosteroids 3alpha-hydroxy-5alpha-pregnane-20-one (allopregnanolone; AlloP) and pregnenolone sulfate (PregS) affect neuronal GABA(A) receptors differently. While AlloP mainly potentiates the currents through GABA(A) receptors, PregS reduces
Autor:
Shu-Cheng Chen, Fong-Sen Wu
Publikováno v:
Brain Research. 1027:196-200
The effect of pregnenolone sulfate (PS) on the capsaicin receptor-mediated current was studied in acutely dissociated rat dorsal root ganglion neurons using the whole-cell voltage-clamp technique. PS acted extracellularly to inhibit the capsaicin-ind
Publikováno v:
Brain Research. 1021:232-240
Taurine (Tau) is one of the most abundant free amino acids in the mammalian central nervous system. Whether the neurotransmission of the central auditory system is regulated or modulated by Tau is not clear. In the present study, we investigated the