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Publikováno v:
Brain Research. 1762:147440
Dysfunctional modulation of brain circuits that regulate the emotional response to potentially threatening stimuli is associated to an inappropriate representation of the emotional salience. Reduced top-down control by cortical areas is assumed to un
Publikováno v:
Brain Research. 1659:148-155
Methamphetamine (METH) is a widely abused psychostimulant displaying potent addictive and neurotoxic properties. METH induces neurotoxicity of dopaminergic terminals and striatal neurons in the striatum. Despite much information on neurotransmitters,
Autor:
Boris V. Safronov, Liliana L. Luz, Elisabete C Fernandes, Olga Kononenko, Daniil Sarkisyan, Joana M. Duarte, Georgy Bakalkin
Publikováno v:
Brain Research
Nociceptive discharges caused by the unilateral tissue damage are processed in the spinal cord by both ipsi- and contralateral neuronal circuits. The mechanisms of the neurotransmitter control of this bilateral excitation spread is poorly understood.
Publikováno v:
Brain Research. 1748:147083
Thienorphine hydrochloride is a new anti-relapse drug for opioid abusers that is currently in phase II clinical trial. In the present study, the antinociception, dependence, and signal transduction induced by thienorphine were examined. Thienorphine
Publikováno v:
Brain Research. 1630:198-207
Systemic bacterial infection results in systemic inflammatory response syndrome due to the release of lipopolysaccharide (LPS) in blood that can lead to multiple organ failure, shock, and potentially death. Other impact, LPS exposure produces robust
Publikováno v:
Brain Research. 1734:146648
Stimulation of mu opioid receptors using drugs like morphine can increase eating when injected into multiple brain regions including the lateral septum (LS). The LS has been classically associated with reward, anxiety and fearful behaviors but more r
Publikováno v:
Brain Research. 1594:190-203
Interactions of opioid receptors with other receptor families can be made use of to improve analgesia and reduce adverse effects of opioid analgesics. We investigated interactions of the α2-adrenergic receptor (α2AR) with opioid receptors of the mu
Publikováno v:
Brain Research. 1554:12-20
Extracellular acidosis is a common feature in pain-generating pathological conditions. Acid-sensing ion channels (ASICs), pH sensors, are distributed in peripheral sensory neurons and participate in nociception. Morphine exerts potent analgesic effec
Autor:
Danielle C. Malkusz, Richard J. Bodnar, Francis M. Rotella, Salomon Kandov, Nicole J. Amador, Anthony Sclafani, Sean M. Duenas, Khalid Touzani, Arzman Badalia, Julie A. Dela Cruz, Maruf Hossain, Meri Gerges, Sonia Y. Bernal
Publikováno v:
Brain Research. 1542:70-78
The attraction to sugar-rich foods is influenced by conditioned flavor preferences (CFP) produced by the sweet taste of sugar (flavor–flavor learning) and the sugar's post-oral actions (flavor–nutrient) learning. Brain dopamine (DA) circuits are
Autor:
Jianning Zhang, Yuan Zhou, Xin Chen, Yanjun Zhang, Hujie Lu, Zilong Zhao, Ying Li, Hui Zhu, Xiao Liu
Publikováno v:
Brain Research. 1541:69-80
Emerging experimental and clinical data suggest that severe illness, such as traumatic brain injury (TBI), can induce critical illness-related corticosteroid insufficiency (CIRCI). However, underlying mechanisms of this TBI-associated CIRCI remain po