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Autor:
Ai-Mei Liao, Zi-Shan Zhang, Long Pan, Yong-Jian Yuan, Guanghai Yu, Jian Cao, Cui-Zhu Tian, Huang Jihong, Ming Hui, Yu-Qi Dong, Shuai-Nan Zheng, Wen-Jin Lin, Yin-Chen Hou, Xiaoxiao Li, Zeng-Liang Liu
Publikováno v:
Brain Research. 1773:147672
Wheat embryo globulin nutrient (WEGN), with wheat embryo globulin (WEG) as the main functional component, is a nutritional combination that specifically targets memory impairment. In this study, we explored the protective role of WEGN on Alzheimer's
Publikováno v:
Brain Research. 1663:1-8
With the decline of ovarian steroids levels at menopause, many women experience an increase in anxiety and stress sensitivity. The locus coeruleus (LC), a central source of noradrenaline (NE), is activated by stress and is inhibited by β-endorphin.
Publikováno v:
Brain Research. 1659:148-155
Methamphetamine (METH) is a widely abused psychostimulant displaying potent addictive and neurotoxic properties. METH induces neurotoxicity of dopaminergic terminals and striatal neurons in the striatum. Despite much information on neurotransmitters,
Autor:
Carlos A. Mejias-Aponte
Publikováno v:
Brain Research. 1641:258-273
Dopamine (DA) is a neuromodulator that regulates different brain circuits involved in cognitive functions, motor coordination, and emotions. Dysregulation of DA is associated with many neurological and psychiatric disorders such as Parkinson's diseas
Publikováno v:
Brain Research. 1724:146434
As demonstrated in previous studies, early postnatal genistein (GEN) administration to mice pups of both sexes, at doses similar to that of infant soy-based formulas, may affect the development of some steroid-sensitive neuronal circuits (i.e. nitrer
Autor:
Shelley H. Bloom, Joel G. Hashimoto, Douglas K. Beard, Clare J. Wilhelm, Kristine M. Wiren, Melissa L. Roberts
Publikováno v:
Brain Research. 1601:102-116
Women are more sensitive to the harmful effects of alcohol (EtOH) abuse than men, yet the underlying mechanisms remain poorly understood. Previous gene expression analysis of the medial prefrontal cortex (mPFC) following a chronic intoxication paradi
Publikováno v:
Brain Research. 1597:159-167
Plasminogen activators (PAs), which convert plasminogen into the fibrinolytic protease plasmin, may initiate the degradation of amyloid-β (Aβ) to suppress the amyloid pathogenesis. In that way, tissue plasminogen activator (tPA)-mediated plasmin ac
Autor:
Ying Liu, Hong Dong, Shu-jun Lu, Wanchao Yang, Hua Qian, Chun-Yu Song, Ya-fang Wang, Fei-fei Chang, Ziyong Yue
Publikováno v:
Brain Research. 1594:108-114
Propofol is a commonly used intravenous anesthetic that has been demonstrated to be neuroprotective against cerebral ischemia-reperfusion (I/R) injury. It remains unclear whether this protective effect has any relationship with the prevention of neur
Autor:
Chea-Ha Kim, Su-Min Lim, Sung-Su Kim, Soo-Hyun Park, Jun-Sub Jung, Yun-Beom Sim, Su-Jin Kim, Hong-Won Suh
Publikováno v:
Brain Research. 1564:33-40
Sulfonylureas are widely used oral drugs for the treatment of type II diabetes mellitus. In the present study, the effects of sulfonylureas administered supraspinally on kainic acid (KA)-induced hippocampal neuronal cell death and hyperglycemia were
Publikováno v:
Brain research. 1657
The pathogenesis of Alzheimer's disease (AD) is well documented to involve mitochondrial dysfunction which causes subsequent oxidative stress and energy metabolic failure in hippocampus. Methylene blue (MB) has been implicated to be neuroprotective i