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Autor:
Weiping Wang, Lijing Jia, Huifang Cao, Zhenzhen Qu, Zhiyong Wang, Qian Hou, Lichao Zhang, Yuhang Jiang, Shuang Tian
Publikováno v:
Brain research. 1764
Status epilepticus (SE) is a neurological emergency. The pathological hallmark of neuronal damage after epileptic seizures could be the chain reaction of oxygen free radicals. Hydroxylated fullerenes (HFs) are novel and effective free radical scaveng
Autor:
Patrycja Kleczkowska, Agnieszka Kowalczyk, Magdalena Bujalska-Zadrożny, Sándor Benyhe, Engin Bojnik, Andrzej W. Lipkowski, Barbara Nowicka, Karolina Pawlik, Piotr Kosson, Emmanuel Hermans, Anna Lesniak, Aleksandra Misicka
Publikováno v:
Brain Research. 1648:172-180
Hybrid compounds are suggested to be a more effective remedy for treatment of various diseases than combination therapy, since the attenuation or total disappearance of side effects, typically induced by a single moiety, can be observed. This is of g
Publikováno v:
Brain Research. 1642:397-408
Alzheime's disease (AD) is an overwhelming neurodegenerative disorder, characterized by synaptic dysfunction, memory loss, neuro-inflammation and neural cell death. Very few treatments are in hand for the management of AD and they are only concentrat
Publikováno v:
Brain Research. 1636:142-151
The possible interactions between the cannabinoid and serotonin systems in the regions of the brain involved in emotional learning and memory formation have been studied by some researchers. In view of the key role of the amygdala in the acquisition
Publikováno v:
Brain Research. 1625:218-237
Reciprocal interactions between nitrergic and dopaminergic systems play a key role in the control of motor behavior. In the present study, we performed a comparative analysis of motor behavior (locomotor activity, catalepsy, rotational behavior) and
Publikováno v:
Brain Research. 1624:78-85
3-O-demethylswertipunicoside (3-ODS) has been reported to protect dopaminergic neurons against neurotoxicity induced by 1-methyl-4-phenylpyridinium (MPP(+)) in PC12 cells. Here, we investigate the neuroprotective effects in vivo and antioxidant activ
Autor:
Jenny Salazar, Nereida Valero, Jesús Mosquera, Melchor Alvarez-Mon, Ernesto Bonilla, Sirley Alcocer
Publikováno v:
Brain Research. 1622:368-376
Venezuelan equine encephalitis (VEE) virus causes an acute central nervous system infection in human and animals. Melatonin (MLT), minocycline (MIN) and ascorbic acid (AA) have been shown to have antiviral activities in experimental infections; howev
Publikováno v:
Brain Research. 1734:146648
Stimulation of mu opioid receptors using drugs like morphine can increase eating when injected into multiple brain regions including the lateral septum (LS). The LS has been classically associated with reward, anxiety and fearful behaviors but more r
Publikováno v:
Brain Research. 1734:146759
Dopamine is the predominant catecholamine neurotransmitter in the mammalian brain which has been shown to play a critical role in antinociceptive process. Previous studies have shown that the role of CA1 region of the hippocampus in antinociception i
Autor:
In-Beom Kim, Yun Ju Chae, Ji Hyun Jeon, Sang June Hahn, Jin-Sung Choi, Ki-Wug Sung, Hong Joon Lee
Publikováno v:
Brain Research. 1597:77-85
Donepezil is a potent, selective inhibitor of acetylcholinesterase, which is used for the treatment of Alzheimer's disease. Whole-cell patch-clamp technique and Western blot analyses were used to study the effects of donepezil on the human ether-a-go