Zobrazeno 1 - 10
of 84
pro vyhledávání: ''
Publikováno v:
Brain Research. 1597:159-167
Plasminogen activators (PAs), which convert plasminogen into the fibrinolytic protease plasmin, may initiate the degradation of amyloid-β (Aβ) to suppress the amyloid pathogenesis. In that way, tissue plasminogen activator (tPA)-mediated plasmin ac
Autor:
Michihiro Igarashi, Kosuke Ando, Masami Takahashi, Ryoki Ishikawa, Kyota Aoyagi, Yoshihisa Kudo
Publikováno v:
Brain Research. 1535:1-13
The purpose of this study was to determine whether calmodulin (CaM) plays a role in neurotransmitter release by examining the effect that ophiobolin A (OBA), a CaM antagonist, on neurotransmitter release from clonal rat pheochromocytoma PC12 cells, p
Publikováno v:
Brain Research. 1149:76-86
MAP kinase is associated with delta-opioid receptor (DOR) signaling and plays a role in cell survival/death. Since anisomycin may alter MAP kinase activity and affect neuronal survival, we investigated whether anisomycin alters neuronal response to h
Autor:
Youxuan Wu, Guangde Yang, Xiao-Dan Hu, Yulang Fei, Kai-Ge Ma, Yi-Hua Qian, Ying Wang, Wei-Na Yang, Shuai Zha, Yaojie Zhang, Mengping Liu, Chang Liu
Publikováno v:
Brain research. 1631
Our previous studies demonstrated that tanshinone IIA (tan IIA) has significant protective effects against the neurotoxicity induced by β-amyloid protein (Aβ) in cultured cortical neurons and PC12 cells. This study was designed to investigate the p
Publikováno v:
Brain Research. 1085:183-188
Alzheimer's disease (AD) is associated with increased production of new neurons (neurogenesis), which may be directed at brain repair. However, the effect of drugs used to treat AD on neurogenesis is unknown. We administered tacrine, galantamine or m
Publikováno v:
Brain Research. 1057:81-87
We investigated the effects of histamine H1 antagonists on acutely dissociated neurons from the rat cortex using the patch-clamp technique. First-generation antihistamines, such as pyrilamine, d-chlorpheniramine, diphenhydramine, and ketotifen, suppr
Publikováno v:
Brain Research. 1044:8-15
The neuroprotective effects of minocycline-which is broadly protective in neurologic-disease models featuring cell death and is being evaluated in clinical trials-were investigated both in vitro and in vivo. For the in vivo study, focal cerebral isch
Publikováno v:
Brain Research. 1002:76-85
Previous studies suggest the protective potentiality of Ginkgo biloba (EGb 761) against apoptotic cell death induced by hydroxyl radicals, staurosporine, serum deprivation and beta-amyloid (betaA) peptide. We have extended these observations to cultu
Publikováno v:
Brain Research. 964:31-41
Recent evidence indicates that the superior colliculus (SC), in addition to its functions in sensory detection, also participates in controlling the generalized activation state of the forebrain, as measured by the electroencephalogram (EEG) or elect
Autor:
David L. Martin, Graeme F. Mason, Sandra B. Martin, Douglas L. Rothman, Nicola R. Sibson, David Manor, Kevin L. Behar, Anant B. Patel
Publikováno v:
Brain Research. 914:81-91
gamma-Aminobutyric acid (GABA) synthesis in the brain is mediated by two major isoforms of glutamic acid decarboxylase, GAD(65) and GAD(67). The contribution of these isoforms to GABA synthesis flux (V(GAD)) is not known quantitatively. In the presen