Zobrazeno 1 - 10
of 135
pro vyhledávání: ''
Autor:
Patrycja Kleczkowska, Agnieszka Kowalczyk, Magdalena Bujalska-Zadrożny, Sándor Benyhe, Engin Bojnik, Andrzej W. Lipkowski, Barbara Nowicka, Karolina Pawlik, Piotr Kosson, Emmanuel Hermans, Anna Lesniak, Aleksandra Misicka
Publikováno v:
Brain Research. 1648:172-180
Hybrid compounds are suggested to be a more effective remedy for treatment of various diseases than combination therapy, since the attenuation or total disappearance of side effects, typically induced by a single moiety, can be observed. This is of g
Autor:
Jin Hee Kim, Hui Chul Choi, Song Hee Lee, Hong Ki Song, Bo Young Choi, Sang Won Suh, Dong Won Lee, Min Sohn
Publikováno v:
Brain Research. 1595:156-165
Citicoline (CDP-choline; cytidine 5'-diphosphocholine) is an important intermediate in the biosynthesis of cell membrane phospholipids. Citicoline serves as a choline donor in the biosynthetic pathways of acetylcholine and neuronal membrane phospholi
Publikováno v:
Brain Research. 1543:173-178
Leukocyte behavior in the cerebral microvasculature following vessel occlusion has not been fully elucidated. The purpose of this study was to investigate the effects of cilostazol on leukocyte behavior (rolling and adhesion) in murine cerebral micro
Autor:
Nasim Sadat Pajohanfar, Akbar Pejhan, Bahareh Amin, Abolfazl Rad, Ehsan Mohebbi, Samad Nazemi
Publikováno v:
Brain research. 1657
Background In this study, we evaluated the effects of atorvastatin, a lipid-lowering medication on morphine-induced tolerance and dependence in mice. Methods Tolerance was induced by subcutaneous administration of morphine (20 mg/kg) to animals, twic
Autor:
Min Cai, Jun Xiang, Xiangting Li, Zhennian Zhang, Ting Wu, Jingsi Zhang, Wen Zhang, Wen-Wei Li, Dingfang Cai, Zhonghai Yu
Publikováno v:
Brain research. 1655
Subcutaneous administration of rotenone has recently attracted attention because of its convenience, simplicity and efficacy in replicating features of Parkinson's disease (PD) in animal models. However, the wide range of doses reported in the litera
Autor:
Larissa A. Roslavtseva, Ilya D. Ionov
Publikováno v:
Brain Research. 1451:27-33
Motor neurons (MNs) of an adult rat are normally insensitive to the neurotoxic action of NMDA. Meanwhile, the experiments in non-motor neurons showed that sensitivity to NMDA can be increased by bicuculline, an antagonist at GABA(A) receptors. The ai
Publikováno v:
Brain Research. 1423:77-86
The neurotoxic effects of cerebrospinal fluid (CSF) from patients suffering amyotrophic lateral sclerosis (ALS), have been reported by various authors. However, variable results have been communicated and the mechanism of such neurotoxicity has been
Publikováno v:
Brain Research. 1414:1-9
The mechanisms implicated in the sympathoexcitation and pressor the response elicited by central CB1R activation are not fully understood. Further, the few reported mechanistic studies on this endeavor were conducted in anesthetized rats. Therefore,
Publikováno v:
Brain Research. 1406:1-7
Neuropathic pain is a debilitating condition that is often difficult to treat using conventional pharmacological interventions and the exact mechanisms involved in the establishment and maintenance of this type of chronic pain have yet to be fully el
Autor:
Tomoko Ohkubo, Tomoki Sakaguchi, Masaru Asari, Shinya Iida, Tomohiro Omura, Manabu Suno, Keiko Shimizu, Kazuo Matsubara, Takehiro Yamada, Yoshikazu Tasaki
Publikováno v:
Brain Research. 1344:25-33
http://dx.doi.org/10.1016/j.brainres.2010.04.085
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by dopaminergic neuronal death in the substantia nigra pars compacta. There is growing interest in the effects of nons
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by dopaminergic neuronal death in the substantia nigra pars compacta. There is growing interest in the effects of nons