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Publikováno v:
Brain research. 1768
T-cell restriction intracellular antigen 1 (TIA1) is an RNA-binding protein that is a major component of stress granules (SGs). The low complexity domain (LCD) of TIA1 plays a central role in facilitating SGs assembly through liquid-liquid phase sepa
Autor:
Xinxiang Yan, Qiying Sun, Yu-pei Guo, Jifeng Guo, Qian Xu, Bei-sha Tang, Hong-li Liu, Juan-juan Huang
Publikováno v:
Brain Research. 1712:25-33
PLA2G6-associated neurodegeneration (PLAN, NBIA2) is the second most common type of neurodegeneration with brain iron accumulation (NBIA), caused by recessive mutations of PLA2G6 gene, which encodes Ca2+-independent phospholipase A2β (iPLA2β). In m
Autor:
Rina Bandopadhyay, Conceição Bettencourt, Chi-Yee Fok, Amrita Verma, Patrick A. Lewis, Kirsten Ebanks
Publikováno v:
Brain Research
Highlights • In silico comparative analysis of LRRK2 direct interactors in brain, lung and kidney using Protein interaction databases and gene enrichment analysis. • 7 promising therapeutic interactors identified: MAP2K6, MATK, MAPT, PAK6, SH3GL2
Autor:
Ka Xiong, Rachel E. Cohen, Brooke Jones, David S. Sharlin, Quan Tran, Geoffrey M. Goellner, Ashani Sudasinghe, Keenan T. Hartert
Publikováno v:
Brain research. 1766
Mutation in proteins containing polyglutamine (polyQ) tracts has been shown to underlie a number of severe human neurodegenerative disorders such as Huntington’s Disease and Spinocerebellar Ataxia. In this study, we identify and describe FAM171B as
Publikováno v:
Brain research. 1747
GPR56/ADGRG1 is a member of the adhesion G-protein coupled receptor (aGPCR) family and one of the important players in the normal development of the brain. It plays a pivotal role in the diverse neurobiological processes, including cortical formation
Autor:
Madison K. Grant, Hannah C. Schriever, Khan Hekmatyar, James D. Lauderdale, Ashley M. Rasys, J. Branson Byers, Anastasia M. Bobilev
Publikováno v:
Brain research. 1732
PAX6 encodes a highly conserved transcription factor necessary for normal development of the eyes and central nervous system. Heterozygous loss-of-function mutations in PAX6 cause the disorder aniridia in humans and the Small eye trait in mice. Aniri
Autor:
Hugo J. Bellen, Kerstin K. Landrock, Richard A. Gibbs, David S. Goldstein, Brett H. Graham, Rui Chen, Heidi Martini-Stoica, Patti Sullivan, George Stoica, Shinya Yamamoto, Marcello D'Amelio
Publikováno v:
Brain Res
In this study, we analyze the neuropathological and biochemical alterations involved in the pathogenesis of a neurodegenerative/movement disorder during different developmental stages in juvenile rats with a mutant Myosin5a (Myo5a). In mutant rats, a
Autor:
Sandra Maday
Publikováno v:
Brain Research. 1649:143-150
Autophagy is an evolutionarily conserved lysosomal degradation pathway that removes damaged organelles and protein aggregates from the cytoplasm. Being post-mitotic, neurons are particularly vulnerable to the accumulation of proteotoxins and are thus
Autor:
Julie D. Atkin, Sonam Parakh
Publikováno v:
Brain Research. 1648:633-649
Protein misfolding leads to the formation of aggregated proteins and protein inclusions, which are associated with synaptic loss and neuronal death in neurodegenerative diseases. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that
Publikováno v:
Brain Research. 1648:538-541
Photoreceptors are specialized sensory neurons essential for light detection in the human eye. Photoreceptor cell dysfunction and death cause vision loss in many eye diseases such as retinitis pigmentosa and achromatopsia. Endoplasmic reticulum (ER)