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Autor:
Shawn Ritchie, Dushmanthi Jayasinghe, Marc Morissette, Mélanie Bourque, Edith Miville-Godbout, Thérèse Di Paolo, Sara Al-Sweidi, Tara C. Smith
Publikováno v:
Brain Research. 1674:70-76
Ethanolamine plasmalogens (PlsEtn) are a class of glycerophospholipids characterized by a vinyl-ether bond at the sn-1 position that play an important role in the structure and function of membranes. Previous reports have suggested a link between red
Publikováno v:
Brain Research. 1670:14-23
Leptomycin B (LMB), originally developed as an anti-fungal agent, has potent neuroprotective properties against status epilepticus (SE, a prolonged seizure activity). However, the pharmacological profiles and mechanisms of LMB for neuroprotection rem
Publikováno v:
Brain Research. 1642:397-408
Alzheime's disease (AD) is an overwhelming neurodegenerative disorder, characterized by synaptic dysfunction, memory loss, neuro-inflammation and neural cell death. Very few treatments are in hand for the management of AD and they are only concentrat
Publikováno v:
Brain Research. 1625:198-205
Tetrahydrobiopterin (BH4) is a critical determinant of nitric oxide (NO) production by nitric oxide synthase (NOS) in the vascular endothelium and its biosynthesis is regulated by the enzymatic activity of GTP-cyclohydrolase I (GTPCH I). The present
Autor:
Danyu Lin, Xiuna Jing, Xia Wu, Ying Chen, Songhua Xiao, Enxiang Tao, Zhifen Zeng, Yanran Liang, Wei Bi, Jun Liu, Lianhong Yang, Shu-Qiong Liu
Publikováno v:
Brain Research. 1622:43-50
A growing body of evidence has supported that environmental factors, such as exposure to heavy metal and pesticides, play an important role in the pathogenesis of Parkinson׳s disease (PD). Rotenone, the active ingredient in various pesticides, has b
Autor:
Qinmei Wang, Chuanming Luo, Guangqing Xu, Xiao-fei He, Yue Lan, Qun Zhang, Fengyin Liang, Zhong Pei
Publikováno v:
Brain Research. 1622:361-367
Microinfarcts are common in patients with cognitive decline and dementia. Allopurinol (ALLO), a xanthine oxidase (XO) enzyme inhibitor, has been found to reduce proinflammatory molecules and oxidative stress in the vasculature. We here examined the e
Publikováno v:
Brain Research. 1624:78-85
3-O-demethylswertipunicoside (3-ODS) has been reported to protect dopaminergic neurons against neurotoxicity induced by 1-methyl-4-phenylpyridinium (MPP(+)) in PC12 cells. Here, we investigate the neuroprotective effects in vivo and antioxidant activ
Publikováno v:
Brain Research. 1622:64-71
Oleanolic acid is a triterpenoid that has been shown to possess antioxidant properties. In this study we investigated the effects of oleanolic acid in a parkinsonian rat model. Unilateral 6-hydroxydopamine (6-OHDA) lesions were carried out on postnat
Publikováno v:
Brain Research. 1597:159-167
Plasminogen activators (PAs), which convert plasminogen into the fibrinolytic protease plasmin, may initiate the degradation of amyloid-β (Aβ) to suppress the amyloid pathogenesis. In that way, tissue plasminogen activator (tPA)-mediated plasmin ac
Publikováno v:
Brain research. 1672
Our aim was to explore the preventive and therapeutic effects of sodium (±)-5-bromo-2-(α-hydroxypentyl) benzoate (brand name: brozopine, BZP) on stroke in Dahl Salt-sensitive (Dahl-SS) hypertensive rats. Dahl-SS rats were fed a high-salt diet to ob