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Publikováno v:
Brain research. 1766
Alzheimer’s disease (AD) is one of the greatest geriatric medicinal challenges of our century and is the main disease leading to dementia. Despite extensive scientific research advances, available disease-modifying treatment strategies remained lim
Autor:
Ai-Mei Liao, Zi-Shan Zhang, Long Pan, Yong-Jian Yuan, Guanghai Yu, Jian Cao, Cui-Zhu Tian, Huang Jihong, Ming Hui, Yu-Qi Dong, Shuai-Nan Zheng, Wen-Jin Lin, Yin-Chen Hou, Xiaoxiao Li, Zeng-Liang Liu
Publikováno v:
Brain Research. 1773:147672
Wheat embryo globulin nutrient (WEGN), with wheat embryo globulin (WEG) as the main functional component, is a nutritional combination that specifically targets memory impairment. In this study, we explored the protective role of WEGN on Alzheimer's
Publikováno v:
Brain Research. 1688:103-112
The mitogen-activated protein kinase (MAPK), especially its extracellular signal-regulated kinase (ERK) subfamily, is a group of kinases enriched in the mammalian brain. While ERK is central to cell signaling and neural activities, the regulation of
Publikováno v:
Brain Res
Although there is strong evidence for cholinergic projections to the rat inferior colliculus, especially from the pedunculopontine tegmental nucleus (Noftz et al., 2020), there is a lack of information about the quantitative prevalence of the enzymes
Publikováno v:
Brain research. 1727
Background Preoperative pain and impaired endogenous analgesia are risk factors of chronic postsurgical persistent pain (CPSP). A Chronic neuropathic pain model induced by spinal nerve ligation (SNL6W) shows impaired endogenous analgesia and delayed
Publikováno v:
Brain Research. 1592:1-10
The neurons of medial septal diagonal band of broca (MSDB) project to hippocampus and play an important role in MSDB-hippocampal synaptic transmission, plasticity and network oscillation. Nicotinic acetylcholine receptor (nAChR) subunits, α4β2 and
Autor:
Chang-Kai Guo
Publikováno v:
Brain research. 1681
In mammals, vestibular hair cells (VHCs) are classified as type I and II according to morphological criteria. Acetylcholine (ACh) is identified as the primary efferent neurotransmitter. To date, cholinergic activities have been reported in mammalian
Autor:
Erina Kadowaki, Kazuyoshi Arishima, Natsuko Hemmi, Takuya Kaneko, Shuntaro Hara, Yosuke Haga, Aisa Ozawa, Masako Yamamoto, Kou Sakabe, Takehiro Maki, Hitomi Sekiguchi, Motoharu Sakaue
Publikováno v:
Brain Research. 1537:37-45
The main target of neurotoxins is neurons because they comprise the main part of neural function, but glial cells may be indirect targets because they support the function of neurons. Among the glial cells, astrocytes in particular act as "nurse cell
Autor:
Michihiro Igarashi, Kosuke Ando, Masami Takahashi, Ryoki Ishikawa, Kyota Aoyagi, Yoshihisa Kudo
Publikováno v:
Brain Research. 1535:1-13
The purpose of this study was to determine whether calmodulin (CaM) plays a role in neurotransmitter release by examining the effect that ophiobolin A (OBA), a CaM antagonist, on neurotransmitter release from clonal rat pheochromocytoma PC12 cells, p
Autor:
Cristiane Busnardo, Gislaine Garcia Pelosi, Fernando M.A. Correa, Milena V. Deolindo, Leonardo B.M. Resstel
Publikováno v:
Brain Research. 1371:74-81
In the present study, we describe the cardiovascular effects of local acetylcholine (Ach) microinjection into both the ventrolateral (vlPAG) and dorsal (dPAG) periaqueductal gray areas of anesthetized rats and the possible local receptors involved wi