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Publikováno v:
Brain Research. 1719:30-39
Schizophrenia is known to be a complex and disabling psychiatric disorder. Dopamine receptor antagonists have a significant therapeutic effect in improving the positive symptoms that are associated with the illness. Therefore, dopamine receptor antag
Autor:
Shinn Zong Lin, Yu Chao Wang, Seong Jin Yu, Shuchun Chen, Wei Hsieh, Chung Shi Yang, Yun Wang, Chia Yu Chang
Publikováno v:
Brain Research. 1719:124-132
Increasing evidence has supported that transplantation of human stem cells induces neuroprotective and reparative effects in animal models of Parkinson’s disease (PD). However, without systemic immunosuppressive therapy, most of these grafted cells
Publikováno v:
Brain Research. 1717:66-73
Ischemic preconditioning (IPC) exerts protective effects against ischemic cerebral injury. In the present study, an in vitro model of cerebral ischemia (oxygen and glucose deprivation, OGD) was established to investigate the neuroprotective mechanism
Publikováno v:
Brain Research. 1715:203-212
The dopaminergic neurodegeneration in the substantia nigrapars compacta (SNpc) and striatum of the midbrain is the important pathological feature of Parkinson's disease (PD). It has been shown that autophagy and endoplasmic reticulum stress (ERS) are
Publikováno v:
Brain Research. 1710:163-172
Inflammation is the focus of many studies on traumatic brain injury (TBI) treatment and outcomes improvement. Some studies have demonstrated that the inhibition of NOD-like receptor protein-3 (NLRP3) inflammasome activation is a potential strategy fo
Autor:
Hong An, Xunming Ji, Ran Meng, Di Wu, Kai Dong, Jun Zhang, Ying Zhang, Chuanjie Wu, Xiaoduo He, Yunxia Duan, Mo Zhang, Wenjing Wei, Yuchuan Ding, Jingfei Shi, Xinglong Zhi
Publikováno v:
Brain Research. 1710:173-180
The combination of pharmacological hypothermia - dihydrocapsaicin (DHC) and intra-arterial regional cooling infusions (RCI) was found to enhance the efficiency of hypothermia and efficacy of hypothermia-induced neuroprotection in acute ischemic strok
Autor:
Zhe Li, Hong Ma, Paul F. White, Xuezhao Cao, Xi-Jia Sun, Yong Cui, Yongjian Zhou, Xiaohan Xu, Yanhua Jiang
Publikováno v:
Brain Research. 1706:116-124
Recent studies indicate that glucagon-like peptide 1 (GLP-1) receptor (GLP-1R) agonists exhibit neurotrophic and neuroprotective effects. The aim of this study was to explore whether the GLP-1R agonist exendin-4 can alter surgery-induced behavioral d
Autor:
Yong-Juan Wu, Wen-Bin Li, Hui-Xian Jia, Qiang Yuan, Xiao-Li Liu, Shu-Qin Li, Lin Feng, Xiao-Zhang, Xiao-Cai Sun
Publikováno v:
Brain Research. 1707:172-183
Our previous studies have demonstrated that limb ischemic preconditioning (LIP) induced brain ischemic tolerance and up-regulated the expression of p38 MAPK and ERK in the hippocampal CA1 region in rats. The present study was undertaken to investigat
Autor:
Seung-Cheol Chang, Hae Young Chung, Won-Jong Lee, Yujeong Lee, Seulah Lee, Hyung Ryong Moon, Jung-Hyun Cho, Jaewon Lee
Publikováno v:
Brain Research. 1704:47-58
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors and are considered promising therapeutic targets in several neurodegenerative diseases. A number of PPAR agonists have been shown to have neuroprotective properties in the pres
Publikováno v:
Brain Research. 1704:1-10
Dendrobium is one of the most important traditional Chinese medicinal foods used to treat age-related disorders. However, it remains unclear whether Dendrobium affects the progression of Alzheimer’s disease (AD). In the present study, we investigat