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Autor:
Rosalba Carrozzo, Giuliano Torre, Stefania Petrini, Carlo Dionisi-Vici, Diego Martinelli, Maya El Hachem, Enrico Bertini, Christian A. Drouin, Irène Ceballos-Picot, Lorena Travaglini, Laurence Hubert, Alexandre Montpetit, Pascale de Lonlay, Teresa Rizza
Publikováno v:
Brain. 136:872-881
MEDNIK syndrome-acronym for mental retardation, enteropathy, deafness, neuropathy, ichthyosis, keratodermia-is caused by AP1S1 gene mutations, encoding σ1A, the small subunit of the adaptor protein 1 complex, which plays a crucial role in clathrin c
Autor:
Wendy Leadbeater, Steven J. Jacques, Martin Berry, Ana Maria Gonzalez, Kevin C. Morrison, Michael R. Douglas, Zubair Ahmed, Ann Logan
Publikováno v:
Brain. 132:3102-3121
Inhibition of central nervous system axon growth is reportedly mediated in part by calcium-dependent phosphorylation of axonal epidermal growth factor receptor, with local administration of the epidermal growth factor receptor kinase inhibitors AG147
Autor:
Makoto Tominaga, Tetsuo Fukuoka, Xiuyu Cui, Shenglan Wang, Koichi Obata, Yi Dai, Koichi Noguchi, Hiroki Yamanaka, Kimiko Kobayashi
Publikováno v:
Brain. 131:1241-1251
Bradykinin is an inflammatory mediator that plays a pivotal role in pain and hyperalgesia in inflamed tissues by exciting and/or sensitizing nociceptors. TRPA1 is an important component of the transduction machinery through which environmental irrita
Autor:
David H. Small, Sharon Unabia, Marie-Isabel Aguilar, Qiao-Xin Li, Steven Petratos, Danuta Maksel, Xu Hou, Megan Kerr, Irene Hatzinisiriou, Amee J George
Publikováno v:
Brain. 131:90-108
Neuritic abnormalities are a major hallmark of Alzheimer's disease (AD) pathology. Accumulation of beta-amyloid protein (Abeta) in the brain causes changes in neuritic processes in individuals with this disease. In this study, we show that Abeta decr
Publikováno v:
Brain. 128:345-355
We trace the cause of congenital myasthenic syndromes in two patients to mutations in the epsilon subunit of the muscle acetylcholine receptor (AChR). Both patients harbour deletion of an asparagine residue in the epsilon subunit (epsilonN436del) at