Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ochi A"'
Autor:
Makoto Tanaka, Akiko Kunishige, Yasuaki Hashimoto, Hiroyuki Yamada, Kazuhito Kawabata, Yasuo Ochi, Satoshi Nishikawa, Hiroshi Mori, Masafumi Sugitani, Naoki Kawada, Ryoji Kayasuga, Yasutomo Nakanishi
Publikováno v:
Bone. 65:1-8
This study examined the effect of ONO-5334, a cathepsin K inhibitor, on bone turnover, mineral density (BMD), mechanical strength and microstructure in ovariectomized (OVX) cynomolgus monkeys. Vehicle, ONO-5334 (3, 10 or 30 mg/kg) or alendronate (0.5
Autor:
Toshitaka Nakamura, Makoto Tanaka, Hiroshi Mori, Taisei Masuda, Hiroyuki Yamada, Masako Ito, Katsuya Kishikawa, Ryoji Kayasuga, Yasuo Ochi
Publikováno v:
Bone. 43:840-848
This study examined the effect of the highly potent nitrogen-containing bisphosphonate, minodronic acid (ONO-5920/YM529), on bone mineral density (BMD), bone turnover, bone microarchitecture and bone strength in ovariectomized (OVX) cynomolgus monkey
Autor:
Kazuhito Kawabata, Makoto Tanaka, Yasutomo Nakanishi, Mark Bruce, Hiroshi Mori, Satoshi Nishikawa, Yasuo Ochi, Hiroyuki Yamada, Yasuaki Hashimoto, Steve Deacon
Publikováno v:
Bone. 86
We examined the effects of ONO-5334, a cathepsin K inhibitor, on bone markers, BMD, strength and histomorphometry in ovariectomized (OVX) cynomolgus monkeys. ONO-5334 (1.2, 6 and 30mg/kg/day, p.o.), alendronate (0.05mg/kg/2weeks, i.v.), or vehicle wa
Autor:
Kazuhito Kawabata, Yasuo Ochi, Ryoji Kayasuga, Makoto Tanaka, Hiroyuki Yamada, Yasutomo Nakanishi, Masafumi Sugitani, Yasuaki Hashimoto, Naoki Kawada, Satoshi Nishikawa, Hiroshi Mori, Akiko Kunishige
Publikováno v:
Bone. 49(6)
In the present study, we examined the in vitro and in vivo pharmacological effects of ONO-5334, a novel inhibitor of cathepsin K, on bone metabolism. In vitro experiments indicated that ONO-5334 is a potent inhibitor of cathepsin K with Ki value of 0
Autor:
Ryoji Kayasuga, Makoto Tanaka, Yasuo Ochi, Hiroshi Mori, Hiroyuki Yamada, Naoki Kawada, Katsuya Kishikawa
Publikováno v:
Bone. 43(5)
The present study examined the effect of the highly potent nitrogen-containing bisphosphonate, minodronic acid (ONO-5920/YM529), on bone mineral density (BMD), bone turnover, bone histomorphometry and bone strength in ovariectomized (OVX) rats. Femal
Autor:
Hiroshi Mori, Kazuhito Kawabata, Yasuaki Hashimoto, Yasutomo Nakanishi, Satoshi Nishikawa, Hiroyuki Yamada, Masafumi Sugitani, Yasuo Ochi
Publikováno v:
Bone. 50:S157
Autor:
Satoshi Nishikawa, Kazuhito Kawabata, Hiroshi Mori, Hiroyuki Yamada, Yasuo Ochi, Yasuaki Hashimoto, Akiko Kunishige, Masafumi Sugitani
Publikováno v:
Bone. 48:S72
Autor:
Satoshi Nishikawa, Masafumi Sugitani, Yasuo Ochi, Yasuaki Hashimoto, Hiroshi Mori, Hiroyuki Yamada, Kazuhito Kawabata, Akiko Kunishige
Publikováno v:
Bone. 48:S221
Background: Bone is a specialised connective tissue composed of cells and an extracellular matrix, and is maintained through bone remodelling. Bone remodelling is characterised by two opposite activities: formation and resorption. The rate of formati