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Autor:
Nao Matsuyama, Shinobu Shimizu, Kazuto Ueda, Toshihiko Suzuki, Sakiko Suzuki, Ryosuke Miura, Akemi Katayama, Masahiko Ando, Masaaki Mizuno, Akihiro Hirakawa, Masahiro Hayakawa, Yoshiaki Sato
Publikováno v:
BMJ open. 12(4)
IntroductionNeonatal hypoxic-ischaemic encephalopathy (HIE) is an important illness associated with death or cerebral palsy. This study aims to assess the safety and tolerability of the allogenic human multilineage-differentiating stress-enduring cel
Autor:
Ula, Hwang, Christopher, Carpenter, Scott, Dresden, Jeffrey, Dussetschleger, Angela, Gifford, Ly, Hoang, Jesseca, Leggett, Armin, Nowroozpoor, Zachary, Taylor, Manish, Shah
Publikováno v:
BMJ open. 12(4)
IntroductionIncreasingly, older adults are turning to emergency departments (EDs) to address healthcare needs. To achieve these research demands, infrastructure is needed to both generate evidence of intervention impact and advance the development of
Autor:
Kevin Chien-Chang Wu, Ziyi Cai, Qingsong Chang, Shu-Sen Chang, Paul Siu Fai Yip, Ying-Yeh Chen
Publikováno v:
BMJ open. 12(2)
ObjectiveIn the last half of the 20th century, many countries have already abolished antisuicide laws; however, more than 20 countries still adopt them. This paper is the first to systematically explore the association between criminalisation of suic
Autor:
Polak, Tobias, Cucchi, David G.J., van Rosmalen, Joost, Uyl - de Groot, CA (Carin), van de Vathorst, Suzanne
Publikováno v:
BMJ Open, Vol 12, Iss 1 (2022)
BMJ Open, 12(1):e052186. BMJ Publishing Group
BMJ Open
Polak, T B, Cucchi, D G, van Rosmalen, J & Uyl-de Groot, C A 2022, ' Real-world data from expanded access programmes in health technology assessments : A review of NICE technology appraisals ', BMJ Open, vol. 12, no. 1, e052186 . https://doi.org/10.1136/bmjopen-2021-052186
BMJ Open, 12(1):e052186. BMJ Publishing Group
BMJ Open
Polak, T B, Cucchi, D G, van Rosmalen, J & Uyl-de Groot, C A 2022, ' Real-world data from expanded access programmes in health technology assessments : A review of NICE technology appraisals ', BMJ Open, vol. 12, no. 1, e052186 . https://doi.org/10.1136/bmjopen-2021-052186
ObjectivesTo quantify and characterise the usage of expanded access (EA) data in National Institute for Health and Care Excellence (NICE) technology appraisals (TAs). EA offers patients who are ineligible for clinical trials or registered treatment o
Autor:
Thomas Manship, Mark T. Macmillan, Francesca Moroni, John M. Campbell, Paul Noel Brennan, Alison Glover, Alasdair R. Fraser, John F. Dillon, Stuart J. Forbes, Neil W. A. McGowan, Neil Lachlan, David M. Morris, Marc Turner, Chloe Pass, Jonathan A. Fallowfield, Catriona Graham, Scott Semple
Publikováno v:
BMJ Open, Vol 11, Iss 11 (2021)
BMJ Open
Brennan, P N, MacMillan, M, Manship, T, Moroni, F, Glover, A, Graham, C, Semple, S, Morris, D M, Fraser, A R, Pass, C, McGowan, N W A, Turner, M L, Lachlan, N, Dillon, J F, Campbell, J D M, Fallowfield, J A & Forbes, S J 2021, ' Study Protocol: A multicentre, open-label, parallel-group, phase 2, randomised controlled trial of autologous macrophage therapy for liver cirrhosis (MATCH) ', BMJ Open . https://doi.org/DOI: 10.1136/bmjopen-2021-053190
BMJ Open
Brennan, P N, MacMillan, M, Manship, T, Moroni, F, Glover, A, Graham, C, Semple, S, Morris, D M, Fraser, A R, Pass, C, McGowan, N W A, Turner, M L, Lachlan, N, Dillon, J F, Campbell, J D M, Fallowfield, J A & Forbes, S J 2021, ' Study Protocol: A multicentre, open-label, parallel-group, phase 2, randomised controlled trial of autologous macrophage therapy for liver cirrhosis (MATCH) ', BMJ Open . https://doi.org/DOI: 10.1136/bmjopen-2021-053190
IntroductionLiver cirrhosis is a growing global healthcare challenge. Cirrhosis is characterised by severe liver fibrosis, organ dysfunction and complications related to portal hypertension. There are no licensed antifibrotic or proregenerative medic
Autor:
Matthew J. Rowland, Pamela Kearns, Daniel Slade, Simon Gates, Sarah Bowden, Anna Rowe, Tonny Veenith, Joshua Savage, David R Thickett, Dhruv Parekh, Duncan Richards, James Scriven, Julian Bion, Rowena Sharpe, Tony Whitehouse, Benjamin A Fisher
Publikováno v:
BMJ Open
BMJ Open, Vol 11, Iss 11 (2021)
BMJ Open, Vol 11, Iss 11 (2021)
Introduction Severe SARS-CoV-2 infection is associated with a dysregulated immune response. Inflammatory monocytes and macrophages are crucial, promoting injurious, proinflammatory sequelae. Immunomodulation is, therefore, an attractive therapeutic s
Autor:
Katherine J Lee, Alicia J Spittle, Jeanie LY Cheong, Deanne K Thompson, Lex W Doyle, Peter J Anderson, Marta Thio, Jennifer A Dawson, Alice C Burnett, Gehan Roberts, Rod W Hunt, Sarah Mcintyre, Kim M Dalziel, Susan E Jacobs, Louise S Owen, Rodney W Hunt, Karli Treyvaud, Abbey L Eeles, Clare Delany, Rosemarie A Boland, Alex Aldis, Louise Pallot, Tien Polonidis, Krista Rust, Renae Allen
Publikováno v:
BMJ Open
BMJ Open, Vol 11, Iss 11 (2021)
BMJ Open, Vol 11, Iss 11 (2021)
ObjectiveNeonatal conditions can have lifelong implications for the health and well-being of children and families. Traditionally, parents and patients have not been included in shaping the agenda for research and yet they are profoundly affected by
Publikováno v:
BMJ Open. 12:e056367
ObjectivesWe investigated gender differences in the association between mortality and general psychological distress (measured by 12-item General Health Questionnaire, GHQ-12), as an increased mortality risk has been shown in community studies, but g
Autor:
Toni Zhong, Kelly A. Metcalfe, Claire Temple-Oberle, Geoff Porter, Anisha Mahajan, Martin LeBlanc, Katherine Cowan
Publikováno v:
BMJ Open, Vol 11, Iss 8 (2021)
BMJ Open
BMJ Open
BackgroundMajor improvements in breast cancer treatment in the last decade include advancements in postmastectomy breast reconstruction (PMBR). Unfortunately, the studies in PMBR are primarily researcher or industry led with minimal input from patien
Autor:
David Burgner, John B. Carlin, Susan A Clifford, Richard Saffery, Terence Dwyer, Melissa Wake, Peter Würtz, Susan Ellul, Markus Juonala, Katherine Lange
Publikováno v:
BMJ Open
ObjectivesNuclear magnetic resonance (NMR) metabolomics is high throughput and cost-effective, with the potential to improve the understanding of disease and risk. We examine the circulating metabolic profile by quantitative NMR metabolomics of a sam