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Autor:
Nathaniel Dasyam, Tess Ostapowicz, Chris Frampton, Robert Weinkove, Giulia Giunti, Evelyn Bauer, Bethany Andrews, David Ritchie, Catherine M. Bollard, Peng Li, Travis Perera, Ian F. Hermans, Philip George, Brigitta Mester
Publikováno v:
BMJ Open
IntroductionAutologous T-cells transduced to express a chimeric antigen receptor (CAR) directed against CD19 elicit high response rates in relapsed or refractory (r/r) B-cell non-Hodgkin lymphoma (B-NHL). However, r/r B-NHL remissions are durable in
Publikováno v:
BMJ Open
IntroductionScalp nerve block has been proven to be an alternative choice to opioids in multimodal analgesia. However, for the infratentorial space-occupying craniotomy, especially the suboccipital retrosigmoid craniotomy, scalp nerve block is insuff
Autor:
M. Leeman, Jeannine Huisbrink, Martin Dunkelgrun, L Ulas Biter, Julie M A Wijnand, Jan A Apers, Serge J. C. Verbrugge
Publikováno v:
BMJ Open, Vol 10, Iss 2 (2020)
BMJ Open
BMJ Open
IntroductionFast-track protocols often include short-term thromboprophylaxis and short length of hospital stay. These treatment strategies may negatively affect the occurrence and diagnosis of postoperative haemorrhage. Over the years, the rates of v
Autor:
Haruhiko Banno, Akiko Morinaga, Akira Shimizu, Naoto Takahashi, Haruhisa Inoue, Makiko Nagai, Yuishin Izumi, Keiko Imamura, Satoshi Morita, Ryuji Uozumi, Takafumi Ikeda, Ritsuko Hanajima, Takashi Ayaki, Tomoko Hirohashi, Naohiro Egawa, Koji Fujita, Yosuke Fujii, Ryosuke Takahashi, Kazutoshi Nishiyama, Yasuhiro Watanabe, Ryosuke Oki
Publikováno v:
BMJ Open
IntroductionAmyotrophic lateral sclerosis (ALS) is a progressive and severe neurodegenerative disease caused by motor neuron death. There have as yet been no fundamental curative medicines, and the development of a medicine for ALS is urgently requir
Autor:
Takanori Kawasaki, Isao Yokota, Takashi Okada, Kojiro Imai, Hiroshi Fujita, Naohiko Nakanishi, Ayumu Yamada, Takahisa Sawada, Satoaki Matoba, Shigeki Takai
Publikováno v:
BMJ Open
IntroductionAnticoagulant therapy in patients with cancer with venous thromboembolism (VTE) increases the risk of both VTE recurrence and haemorrhagic complication. Direct oral anticoagulants (DOACs) have been shown to be effective in preventing VTE
Autor:
Lisa M. Olsen, Christian R. Juhl, Bente Stallknecht, Signe S. Torekov, Mads Rosenkilde, Charlotte Janus, Jens J. Holst, Julie R. Lundgren, Simon Jensen, Sten Madsbad
Publikováno v:
BMJ Open
Jensen, S B K, Lundgren, J R, Janus, C, Juhl, C R, Olsen, L M, Rosenkilde, M, Holst, J J, Stallknecht, B M, Madsbad, S & Torekov, S S 2019, ' Protocol for a randomised controlled trial of the combined effects of the GLP-1 receptor agonist liraglutide and exercise on maintenance of weight loss and health after a very low-calorie diet ', BMJ Open, vol. 9, no. 11, e031431 . https://doi.org/10.1136/bmjopen-2019-031431
Jensen, S B K, Lundgren, J R, Janus, C, Juhl, C R, Olsen, L M, Rosenkilde, M, Holst, J J, Stallknecht, B M, Madsbad, S & Torekov, S S 2019, ' Protocol for a randomised controlled trial of the combined effects of the GLP-1 receptor agonist liraglutide and exercise on maintenance of weight loss and health after a very low-calorie diet ', BMJ Open, vol. 9, no. 11, e031431 . https://doi.org/10.1136/bmjopen-2019-031431
IntroductionThe success rate of weight loss maintenance is limited. Therefore, the purpose of this study is to investigate the maintenance of weight loss and immunometabolic health outcomes after diet-induced weight loss followed by 1-year treatment
Autor:
Amy E. Wright, Douglas M Campbell, Laurie J. Morrison, Carol Strike, Aaron Orkin, Pamela Leece, Geoffrey Milos, Ruby Sniderman, Rita Shahin, Michelle Klaiman, Mercy Charles, Kevin E. Thorpe, Janet A. Parsons, Kate Sellen, Sooner Investigators, Shaun Hopkins, Curtis Handford
Publikováno v:
BMJ Open
IntroductionThe surviving opioid overdose with naloxone education and resuscitation (SOONER) project uses co-design and trial methods to develop and evaluate a point-of-care overdose education and naloxone distribution (OEND) tool. We plan to conduct
Publikováno v:
BMJ Open
IntroductionParacetamol (acetaminophen) is widely used for management of mild-to-moderate pain and reduction of fever. It is available as immediate release (IR) and modified-release (MR) formulation. In 2017, European Medicines Agency recommended a s
Autor:
Reena Engineer, Shraddha Patkar, Shirley Christabel Lewis, Ashutosh Das Sharma, Nitin Shetty, Vikas Ostwal, Anant Ramaswamy, Supriya Chopra, Archi Agrawal, Prachi Patil, Shaesta Mehta, Mahesh Goel
Publikováno v:
BMJ Open
IntroductionNeoadjuvant chemotherapy (NACT) is considered the current standard for locally advanced gallbladder cancer (GBC). There is no consensus on the optimal neoadjuvant approach. A pilot study from our institution has shown improved overall sur
Autor:
Cynthia Brandt, Charles Lu, Laura Bankowski, Yauheni Solad, Hyung Paek, Erik P. Hess, Molly M. Jeffery, James Dziura, Shara Martel, Mehul D. Patel, Jodi A. Mao, Gail D'Onofrio, Edward R. Melnick, Timothy F. Platts-Mills
Publikováno v:
BMJ Open
IntroductionThe goal of this trial is to determine whether implementation of a user-centred clinical decision support (CDS) system can increase adoption of initiation of buprenorphine (BUP) into the routine emergency care of individuals with opioid u