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Autor:
Ryosuke Shirakawa, Shintaro Kinugawa, Takashi Yokota, Shingo Takada, Naoya Kakutani, Takaaki Furihata, Hideo Nambu, Satoshi Maekawa
Publikováno v:
BMC Pharmacology & Toxicology
BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-10 (2021)
BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-10 (2021)
Background Doxorubicin (DOX) is widely used as an effective chemotherapeutic agent for cancers; however, DOX induces cardiac toxicity, called DOX-induced cardiomyopathy. Although DOX-induced cardiomyopathy is known to be associated with a high cumula
Autor:
Takashi Seto, Masashi Kimura, Y. Kogure, Kenichi Suzuki, Toshinobu Hayashi, Mototsugu Shimokawa, Tomomi Takiguchi, Takeshi Koike, Satoru Shimizu, Makoto Nishio, Reiko Matsui, Tomohiko Harada, Kimiko Fujiwara, Naoyuki Nogami, Hirotsugu Kenmotsu, Koichi Goto, Hiroyasu Kaneda
Publikováno v:
BMC Pharmacology & Toxicology
BMC Pharmacology and Toxicology, Vol 21, Iss 1, Pp 1-10 (2020)
BMC Pharmacology and Toxicology, Vol 21, Iss 1, Pp 1-10 (2020)
Background Of patients receiving moderate emetic risk chemotherapy (MEC), 30–90% experience chemotherapy-induced nausea and vomiting (CINV); however, the optimal antiemetic treatment remains controversial. Methods In this multicenter, prospective,
Publikováno v:
BMC Pharmacology & Toxicology
BMC Pharmacology and Toxicology, Vol 21, Iss 1, Pp 1-8 (2020)
BMC Pharmacology and Toxicology, Vol 21, Iss 1, Pp 1-8 (2020)
Background Hyponatremia, a marker of disease severity and prognosis, has been associated with various clinical factors and drug use, especially diuretics. Methods This observational prospective cohort study enrolled patients hospitalized at the Unive
Autor:
Eduardo de França Damasceno, Miguel N. Burnier, Ruiz Simonato Alonso, Marcelo Palis Ventura, H. P. Solari
Publikováno v:
BMC Pharmacology & Toxicology
BMC Pharmacology and Toxicology, Vol 21, Iss 1, Pp 1-7 (2020)
BMC Pharmacology and Toxicology, Vol 21, Iss 1, Pp 1-7 (2020)
Background The study aimed to evaluate and compare the leukocyte chemotactic activities of various brimonidine tartrate (BT) eye drop formulations. Methods A 96-well dot-blot platet using a Boyden-style well was used to study the chemotactic effects
Publikováno v:
BMC Pharmacology & Toxicology
BMC Pharmacology and Toxicology, Vol 21, Iss 1, Pp 1-7 (2020)
BMC Pharmacology and Toxicology, Vol 21, Iss 1, Pp 1-7 (2020)
Background Although recent studies using experimental models of ischemic brain injury indicate that systemically-administered β1-blockers have potential protective effects on the cerebrovascular system, the precise mechanisms remain unclear. In addi
Autor:
Maria Paula Marques, Eduardo Barbosa Coelho, Guilherme Suarez-Kurtz, Jurandyr Moreira de Andrade, Vera Lucia Lanchote, João Paulo Bianchi Ximenez
Publikováno v:
BMC Pharmacology & Toxicology
BMC Pharmacology and Toxicology, Vol 20, Iss S1, Pp 1-10 (2019)
BMC Pharmacology and Toxicology, Vol 20, Iss S1, Pp 1-10 (2019)
Background Tamoxifen is considered a prodrug of its active metabolite endoxifen, which is dependent on the CYP2D6 and CYP3A enzymes. Tamoxifen pharmacokinetic variability influences endoxifen exposure and, consequently, its clinical outcome. This stu
Autor:
Lijie Cai, Yongliang Lv, Ian Denys, Feng Chen, Zhuoying Wang, Xuecui Wang, Juan Gao, Daniel R. Kapusta
Publikováno v:
BMC Pharmacology & Toxicology
BMC Pharmacology and Toxicology, Vol 20, Iss 1, Pp 1-4 (2019)
BMC Pharmacology and Toxicology, Vol 20, Iss 1, Pp 1-4 (2019)
Background Timolol Maleate is a non-selective beta-adrenergic blocker that is commonly used to treat open-angle glaucoma. Despite its topical administration, ophthalmic timolol enters systemic circulation and produces a systemic beta-adrenergic block
Autor:
Fangfang Xia, Yaoyao Cai, Shi Wang, Tingting Lin, Xixi Cai, Linmin Pan, Zhousheng Jin, Hongfei Chen
Publikováno v:
BMC Pharmacology & Toxicology
BMC Pharmacology and Toxicology, Vol 20, Iss 1, Pp 1-8 (2019)
BMC Pharmacology and Toxicology, Vol 20, Iss 1, Pp 1-8 (2019)
BackgroundDexmedetomidine was proved to mitigate bupivacaine-induced cardiotoxicity but mechanism of this ability is still unclear. This study was designed to investigate the direct effects of dexmedetomidine on cardiotoxicity induced by bupivacaine
Autor:
Alemseged Beyene Berha, Workineh Shibeshi, Anandi N. Sheth, Getnet Yimer, Addisu Admasu, Zenebe Negash
Publikováno v:
BMC Pharmacology & Toxicology
BMC Pharmacology and Toxicology, Vol 20, Iss 1, Pp 1-10 (2019)
BMC Pharmacology and Toxicology, Vol 20, Iss 1, Pp 1-10 (2019)
Background Nephrotoxicity and ototoxicity are clinically significant dose-related adverse effects associated with second-line anti-tubercular injectables drugs (aminoglycosides and capreomycin) used during intensive phase of treatment of multi-drug r
Publikováno v:
BMC Pharmacology & Toxicology
BMC Pharmacology and Toxicology, Vol 20, Iss 1, Pp 1-6 (2019)
BMC Pharmacology and Toxicology, Vol 20, Iss 1, Pp 1-6 (2019)
Background Concern about intoxication by e-liquid is growing as calls to poison control centers have increased since their introduction. Only three cases of intoxication by injection have been reported worldwide. Our case is unique because of the pre