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Autor:
Yao Wang, Wenzheng Ju, Anwei Ding, Peidong Chen, Bingting Sun, Yang Zhao, Shijia Liu, Guoliang Dai
Publikováno v:
BMC Pharmacology & Toxicology
BMC Pharmacology and Toxicology, Vol 18, Iss 1, Pp 1-8 (2017)
BMC Pharmacology and Toxicology, Vol 18, Iss 1, Pp 1-8 (2017)
Background Mitiglinide is a widely used agent for diabetic treatment. We established a pharmacokinetic-pharmacodynamic (PK-PD) model to illustrate the relationship between mitiglinide plasma concentration and its glucose lowering effects in healthy v
Autor:
Milica Stojiljković, Marko Stojanovic, Radmila Jankovic, Miroslav Radenković, Mirko Topalović
Publikováno v:
BMC Pharmacology & Toxicology
Background It is well established that diabetes mellitus represents an important risk factor for endothelial dysfunction and associated cardiovascular events. Accordingly, vascular responsiveness of different isolated blood vessels was shown to be al
Autor:
Milica Atanacković, Radmila Novakovic, Vladimir Kanjuh, Jelena Cvejić, Dragana Protić, Ljiljana Gojkovic-Bukarica
Publikováno v:
BMC Pharmacology & Toxicology
Results Resveratrol relaxed RA of normal rats more potently than RA of rats with diabetes (EC50 8 and 50 μM, respectively). L-NAME and methylene blue partly antagonized the relaxation of RA of normal animals only. A nonselective blocker of voltage-g