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Autor:
Xinfang Wang, Junsong Chen
Publikováno v:
BMC Molecular and Cell Biology, Vol 22, Iss 1, Pp 1-11 (2021)
BMC Molecular and Cell Biology
BMC Molecular and Cell Biology
Background Abnormal proliferation and migration of human airway smooth muscle cells (HASMCs) play an important role in the development of childhood asthma. Long non-coding RNAs (lncRNAs) have been demonstrated to participate in HASMC proliferation an
Publikováno v:
BMC Molecular and Cell Biology, Vol 22, Iss 1, Pp 1-13 (2021)
BMC Molecular and Cell Biology
BMC Molecular and Cell Biology
BackgroundEpidermal growth factor receptor (EGFR) and its signaling pathways play a vital role in pathogenesis of lung cancer. By disturbing EGFR signaling, mutations of EGFR may lead to progression of cancer or the emergence of resistance to EGFR-ta
Publikováno v:
BMC Molecular and Cell Biology, Vol 22, Iss 1, Pp 1-15 (2021)
BMC Molecular and Cell Biology
BMC Molecular and Cell Biology
Background Circular RNAs (circRNAs) are endogenous non-coding RNAs, which are associated with various biological processes, including microRNA (miRNA) interaction, protein binding and regulatory splicing. circRNA_0005529 (circ_0005529) is derived fro
Publikováno v:
BMC Molecular and Cell Biology, Vol 21, Iss 1, Pp 1-10 (2020)
BMC Molecular and Cell Biology
BMC Molecular and Cell Biology
Background The SMC5/6 complex, cohesin and condensin are the three mammalian members of the structural maintenance of chromosomes (SMC) family, large ring-like protein complexes that are essential for genome maintenance. The SMC5/6 complex is the lea
Publikováno v:
BMC Molecular and Cell Biology, Vol 20, Iss 1, Pp 1-13 (2019)
BMC Molecular and Cell Biology
BMC Molecular and Cell Biology
Background Astral microtubules emanating from the mitotic centrosomes play pivotal roles in defining cell division axis and tissue morphogenesis. Previous studies have demonstrated that human transforming acidic coiled-coil 3 (TACC3), the most conser
Autor:
Carina Jägers, Henk Roelink
Publikováno v:
BMC Molecular and Cell Biology, Vol 22, Iss 1, Pp 1-18 (2021)
BMC molecular and cell biology, vol 22, iss 1
BMC Molecular and Cell Biology
BMC molecular and cell biology, vol 22, iss 1
BMC Molecular and Cell Biology
Background Sonic Hedgehog (Shh) has a catalytic cleft characteristic for zinc metallopeptidases and has significant sequence similarities with some bacterial peptidoglycan metallopeptidases defining a subgroup within the M15A family that, besides hav
Autor:
Ramesh Iyer, Ramkrishna Sadhukhan, Amy Greischar, Rui Wang, Jennifer Hardman, Denise C. Perron, B. Sielaff, Maria A. Argiriadi, Ievgeniia Dubrovska, Russell A. Judge, John Harlan, David A. Egan, Lei Gao, Marc R. Lake, Bradford L. McRae, Lorenzo Benatuil, Silvino Sousa
Publikováno v:
BMC Molecular and Cell Biology, Vol 20, Iss 1, Pp 1-13 (2019)
BMC Molecular and Cell Biology
BMC Molecular and Cell Biology
Background CD40 is a 48 kDa type I transmembrane protein that is constitutively expressed on hematopoietic cells such as dendritic cells, macrophages, and B cells. Engagement of CD40 by CD40L expressed on T cells results in the production of proinfla
Autor:
Rashi Iyer, Jennifer Foster Harris, Emilia Solomon, Sofiya Micheva-Viteva, Katie Davis-Anderson, Blake T. Hovde, Scott N. Twary
Publikováno v:
BMC Molecular and Cell Biology
BMC Molecular and Cell Biology, Vol 22, Iss 1, Pp 1-21 (2021)
BMC Molecular and Cell Biology, Vol 22, Iss 1, Pp 1-21 (2021)
Background Human induced pluripotent stem cells (iPSC) have opened new avenues for regenerative medicine. Consequently, iPSC-derived motor neurons have emerged as potentially viable therapies for spinal cord injuries and neurodegenerative disorders i
Publikováno v:
BMC Molecular and Cell Biology
BMC Molecular and Cell Biology, Vol 22, Iss 1, Pp 1-11 (2021)
BMC Molecular and Cell Biology, Vol 22, Iss 1, Pp 1-11 (2021)
Background Succinate dehydrogenase (Complex II) plays a dual role in respiration by catalyzing the oxidation of succinate to fumarate in the mitochondrial Krebs cycle and transferring electrons from succinate to ubiquinone in the mitochondrial electr
Autor:
Marcelo Beltrão Molento, John P. Dalton, Orla Drysdale, Krystyna Cwiklinski, Izanara Cristine Pritsch, Heather Jewhurst, Carolina De Marco Verissimo, Irina G. Tikhonova
Publikováno v:
BMC Molecular and Cell Biology
Pritsch, I C, Tikhonova, I G, Jewhurst, H L, Drysdale, O, Cwiklinski, K, Molento, M B, Dalton, J P & Verissimo, C D M 2020, ' Regulation of the Fasciola hepatica newly excysted juvenile cathepsin L3 (FhCL3) by its propeptide: a proposed 'clamp-like' mechanism of binding and inhibition ', Biochemistry and cell biology = Biochimie et biologie cellulaire, vol. 21, 90 . https://doi.org/10.1186/s12860-020-00335-5
BMC Molecular and Cell Biology, Vol 21, Iss 1, Pp 1-17 (2020)
Pritsch, I C, Tikhonova, I G, Jewhurst, H L, Drysdale, O, Cwiklinski, K, Molento, M B, Dalton, J P & Verissimo, C D M 2020, ' Regulation of the Fasciola hepatica newly excysted juvenile cathepsin L3 (FhCL3) by its propeptide: a proposed 'clamp-like' mechanism of binding and inhibition ', Biochemistry and cell biology = Biochimie et biologie cellulaire, vol. 21, 90 . https://doi.org/10.1186/s12860-020-00335-5
BMC Molecular and Cell Biology, Vol 21, Iss 1, Pp 1-17 (2020)
BackgroundThe zoonotic worm parasiteFasciola hepaticasecretes an abundance of cathepsin L peptidases that are associated with virulence, invasiveness, feeding and migration. The peptidases are produced as inactive zymogens that activate at low pH by