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Autor:
Raffaella Ardau, Antonello Pani, Maria Del Zompo, Alberto Bocchetta, Paolo Carta, Claudia Sardu, Franca Ligas
Publikováno v:
BMC Medicine
The adverse renal effects of lithium have long been known, but glomerular insufficiency had been considered an unlikely event until recently, when new studies have raised concern regarding very long-term treatment. In this cross-sectional study, we e
Autor:
Marie-Eve Raguenaud, Say Chy, Lim Keuky, Petros Isaakidis, Wim Van Damme, Gemma Arellano, Tony Reid
Publikováno v:
BMC Medicine
BMC Medicine, Vol 7, Iss 1, p 33 (2009)
BMC Medicine, Vol 7, Iss 1, p 33 (2009)
Background Despite the worldwide increasing burden of diabetes, there has been no corresponding scale-up of treatment in developing countries and limited evidence of program effectiveness. In 2002, in collaboration with the Ministry of Health of Camb
Publikováno v:
BMC Medicine
The standard of care for patients with hormone receptor positive, human epidermal growth factor receptor type 2 negative advanced breast cancer is endocrine therapy. Endocrine agents, including aromatase inhibitors, tamoxifen, and fulvestrant, are of
Autor:
Nathalie M Delfos, Ida C. Spelt, Willize E. van der Starre, Cees van Nieuwkoop, Janneke E. Stalenhoef, Albert M Vollaard, Anna M. van Aartrijk, Jan W. van ’t Wout, Tanny J. K. van der Reijden, Mirjam J. Knol, Jaap T. van Dissel, Martha T. van der Beek, Jeanet W. Blom, Ted Koster, Hans C. Ablij, Eliane M. S. Leyten
Publikováno v:
BMC Medicine
BMC Medicine, 15
BMC Medicine, Vol 15, Iss 1, Pp 1-9 (2017)
BMC Medicine, 15
BMC Medicine, Vol 15, Iss 1, Pp 1-9 (2017)
In adults with febrile urinary tract infection (fUTI), data on optimal treatment duration in patients other than non-pregnant women without comorbidities are lacking. A randomized placebo-controlled, double-blind, non-inferiority trial among 35 prima
Autor:
Takayuki Nakagawa, Tatsunori Sakamoto, Kozo Kumakawa, Yasuhiko Tabata, Takafumi Ikeda, Akira Shimizu, Harukazu Hiraumi, Norio Yamamoto, Akira Sasaki, Atsushi Yonezawa, Michio Yamamoto, Shin-ichi Usami, Naohito Hato, Shizuo Komune, Juichi Ito, Keiji Tabuchi, Keizo Fujiwara, Harue Tada, Shiro Tanaka, Mariko Takahashi, Toshiko Ito-Ihara
Publikováno v:
BMC Medicine
[Background]To date, no therapeutic option has been established for sudden deafness refractory to systemic corticosteroids. This study aimed to examine the efficacy and safety of topical insulin-like growth factor-1 (IGF-1) therapy in comparison to i
Publikováno v:
BMC Medicine
Background Nicotine replacement therapy (NRT) and varenicline are both effective in helping smokers quit. There is growing interest in combining the two treatments to improve treatment outcomes, but no experimental data exist on whether this is effic
Autor:
Ziyad Mahfoud, Ramzi Sabra, Fadi Chamseddine, Mohammad Mikati, Mohammad Itani, Hala Tamim, Mona Nabulsi
Publikováno v:
BMC Medicine
BMC Medicine, Vol 4, Iss 1, p 4 (2006)
BMC Medicine, Vol 4, Iss 1, p 4 (2006)
Background Alternating ibuprofen and acetaminophen for the treatment of febrile children is a prevalent practice among physicians and parents, despite the lack of evidence on effectiveness or safety. This randomized, double-blind and placebo-controll
Autor:
Epaminondas Samantas, Helena Linardou, Dimitrios Bafaloukos, Athanasios M. Dimopoulos, Christos Papadimitriou, Aristotelis Bamias, Pavlos Papakostas, Thomas Makatsoris, Gerasimos Aravantinos, Haralabos P. Kalofonos, Christos Christodoulou, Eleni Timotheadou, Evangelos Briasoulis, Dimitrios Pectasides, George Fountzilas, Paris Kosmidis
Publikováno v:
BMC Medicine
BMC Medicine, Vol 8, Iss 1, p 3 (2010)
BMC Medicine, Vol 8, Iss 1, p 3 (2010)
Background Platinum-based combinations are the standard second-line treatment for platinum-sensitive ovarian cancer (OC). This randomized phase II study was undertaken in order to compare the combination of carboplatin and pegylated liposomal doxorub
Autor:
Nicola Marchi, Damir Janigro, Kerri Hallene, Kelly Kight, Gabriele Dini, William Bingaman, Gabriel Möddel, Annamaria Vezzani, Luca Cucullo
Publikováno v:
BMC Medicine, Vol 2, Iss 1, p 37 (2004)
BMC Medicine
BMC Medicine
Background The multiple drug resistance protein (MDR1/P-glycoprotein) is overexpressed in glia and blood-brain barrier (BBB) endothelium in drug refractory human epileptic tissue. Since various antiepileptic drugs (AEDs) can act as substrates for MDR
Publikováno v:
BMC Medicine, Vol 10, Iss 1, p 9 (2012)
BMC Medicine
BMC Medicine
Background Signal transducer and activator of transcription 3 (STAT3) is activated in majority of ovarian tumors and confers resistance to cisplatin treatment in patients with ovarian cancer. We have reported previously that diindolylmethane (DIM) in