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Autor:
Larisa M. Haupt, Philippa H. Youl, Diego Chacon-Cortes, Lyn R. Griffiths, Rodney A. Lea, Robert A. Smith
Publikováno v:
BMC Medical Genetics
MicroRNAs (miRNAs) are important small non-coding RNA molecules that regulate gene expression in cellular processes related to the pathogenesis of cancer. Genetic variation in miRNA genes could impact their synthesis and cellular effects and single n
Autor:
Sakineh Abbasi
Publikováno v:
BMC Medical Genetics, Vol 11, Iss 1, p 109 (2010)
BMC Medical Genetics
BMC Medical Genetics
ER-alpha and ER-beta genes have been proven to play a significant role in breast cancer. Epidemiologic studies have revealed that age-incidence patterns of breast cancer in Middle East differ from those in the Western countries. Two selected coding r
Autor:
Eglė Šepetauskienė, Elona Juozaitytė, Darius Čereškevičius, Roberta Jankauskaitė, Aistė Savukaitytė, Rasa Ugenskienė
Publikováno v:
BMC Medical Genetics
Background Breast cancer is the most frequent oncological disease among women. Estrogens are known to play an important role in breast cancer development. Recognition of the relationship between polymorphisms within estrogen metabolizing genes and co
Autor:
Nicholas Eriksson, Amy K. Kiefer, Uta Francke, David A. Hinds, Geoffrey M Benton, Joyce Y. Tung, Joanna L. Mountain, Chuong B. Do
Publikováno v:
BMC Medical Genetics, Vol 13, Iss 1, p 53 (2012)
BMC Medical Genetics
BMC Medical Genetics
Background While some factors of breast morphology, such as density, are directly implicated in breast cancer, the relationship between breast size and cancer is less clear. Breast size is moderately heritable, yet the genetic variants leading to dif
Autor:
Daniel Levy, Bernard E. Kreger, Greta Lee Splansky, Carol L. Rosenberg, Joanne M. Murabito, Daniel Finger, Karen H. Antman, Shih-Jen Hwang
Publikováno v:
BMC Medical Genetics
Breast and prostate cancer are two commonly diagnosed cancers in the United States. Prior work suggests that cancer causing genes and cancer susceptibility genes can be identified. We conducted a genome-wide association study (Affymetrix 100K SNP Gen