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Autor:
Brian V. Lananna, Raymond J. Louie, Denise A. Chan, Mercè Padró, Adam J. Krieg, Luika A. Timmerman
Publikováno v:
BMC Cancer
Background About 75–80% of breast tumors express the estrogen receptor alpha (ER-α) and are treated with endocrine-target therapeutics, making this the premier therapeutic modality in the breast cancer clinic. However, acquired resistance is commo
Autor:
David D. Sampson, Brendan F. Kennedy, Christobel Saunders, Bruce Latham, Robert A. McLaughlin, Kelsey M. Kennedy, Lixin Chin, Philip Wijesinghe
Publikováno v:
BMC Cancer
This project is supported with funding from the Australian Research Council; and Cancer Council WA, which allowed us to develop the technology; Department of Health of Western Australia, National Breast Cancer Foundation (Australia); and the National
Autor:
Carlos Caldas, Sergio Gómez, Mathias Gehrmann, Marcus Schmidt, Dorraya El-Ashry, Alex Arenas, Andrew E. Teschendorff
Publikováno v:
BMC Cancer, 10, Article 604. (2010)
BMC Cancer
BMC Cancer, Vol 10, Iss 1, p 604 (2010)
BMC Cancer
BMC Cancer, Vol 10, Iss 1, p 604 (2010)
Background Elucidating the activation pattern of molecular pathways across a given tumour type is a key challenge necessary for understanding the heterogeneity in clinical response and for developing novel more effective therapies. Gene expression si
Autor:
Lucie Tanneau, Marc Debled, Annie J. Sasco, Virginie Rondeau, Simone Mathoulin-Pélissier, Gaëtan MacGrogan
Publikováno v:
BMC Cancer
BMC Cancer, BioMed Central, 2010, 10 (1), pp.697. ⟨10.1186/1471-2407-10-697⟩
BMC Cancer, Vol 10, Iss 1, p 697 (2010)
BMC Cancer, BioMed Central, 2010, 10 (1), pp.697. ⟨10.1186/1471-2407-10-697⟩
BMC Cancer, Vol 10, Iss 1, p 697 (2010)
Background In the setting of recurrent events, research studies commonly count only the first occurrence of an outcome in a subject. However this approach does not correctly reflect the natural history of the disease. The objective is to jointly iden
Autor:
Hossam M. Draz, Nasser M. Al-Daghri, Sobhy M. Yakout, George P. Chrousos, Amal Abdullah Abdulkareem, Abdullah M Alnaami, Amal Alenad, Majed S. Alokail, Shaun Sabico
Publikováno v:
BMC Cancer, Vol 13, Iss 1, p 54 (2013)
BMC Cancer
BMC Cancer
Background Obesity has been linked to many adverse health consequences, including breast cancer. This study aims to determine adipocytokine and other biological changes in recently diagnosed breast cancer patients before therapy is started. Methods A
Autor:
Leticia Labriola, Mari Cleide Sogayar, Luciana Rodrigues Gomes, Rosângela A. M Wailemann, Letícia Ferreira Terra
Publikováno v:
BMC Cancer, Vol 12, Iss 1, p 26 (2012)
BMC Cancer
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
BMC Cancer
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Background Metastasis is the main factor responsible for death in breast cancer patients. Matrix metalloproteinases (MMPs) and their inhibitors, known as tissue inhibitors of MMPs (TIMPs), and the membrane-associated MMP inhibitor (RECK), are essenti
Publikováno v:
BMC Cancer
Background A high neutrophil-to-lymphocyte ratio (NLR) may be related to increased mortality in patients with lung, colorectal, stomach, liver, and pancreatic cancer. To date, the utility of NLR to predict the response to neoadjuvant chemotherapy (NA
Autor:
Biyun Wang, Jian Zhang, Zhonghua Wang, Xiaofeng Xu, Xichun Hu, Xinmin Zhao, Zhen Jia, Qunling Zhang, Si Sun
Publikováno v:
BMC Cancer, Vol 11, Iss 1, p 403 (2011)
BMC Cancer
BMC Cancer
Background To assess prognostic and predictive effects of clinical and biochemical factors in our published randomized study of a weekly low dose (metronomic arm) versus a conventional dosage of zoledronic acid (conventional arm) in breast cancer pat
Autor:
Gundula Ernst, Angela Scherwath, Tahera Ahmad, Karina Oppitz, Heinrich Lanfermann, Ansa Maer Cole, Diana Steinmann, Marie-Christine Cordes, Michael Bremer
Publikováno v:
BMC Cancer
Background Many patients with cancer suffer from distress, anxiety and depression. However, studies on patients with brain metastases are lacking. In this exploratory study we prospectively assessed distress, anxiety and depression in patients with b
Autor:
Geoffrey L. Greene, Lucy Xia, Laurence N. Kolonel, Michael R. Stallcup, Michael F. Press, Chris Hsu, Helen Ha, Christopher A. Haiman, Brian E. Henderson, Loic Le Marchand, Rachel R Garcia, Xin Sheng
Publikováno v:
BMC Cancer
BMC Cancer, Vol 9, Iss 1, p 43 (2009)
BMC Cancer, Vol 9, Iss 1, p 43 (2009)
Background Only a limited number of studies have performed comprehensive investigations of coding variation in relation to breast cancer risk. Given the established role of estrogens in breast cancer, we hypothesized that coding variation in steroid