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Autor:
Basem Al-Otaibi, Huda H. Al-Khalaf, Abdelilah Aboussekhra, Maha H. Daghestani, Huda A. Al-Howail, Amer Al-Mazrou, Hana Hakami, Ibrahim Al-Jammaz
Publikováno v:
BMC Cancer
Background Triple-negative breast cancer (TNBC) is an aggressive histological subtype with limited treatment options and very poor prognosis following progression after standard chemotherapeutic regimens. Therefore, novel molecules and therapeutic op
Autor:
Marguerite Buchanan, James F Reid, Michael Hallett, Abdel Hosein, Mark Basik, Julie Livingstone
Publikováno v:
BMC Cancer
Background Cancer-associated fibroblasts (CAFs) play an important role in breast cancer pathogenesis by paracrine regulation of breast cancer cell biology. Several in vitro and mouse models have characterized the role of cell contact and cytokine mol
Publikováno v:
BMC Cancer
Background The prognoses of young breast cancer patients are poor. The purpose of this study is to evaluate the different characteristics and prognoses among different subtypes of young breast cancer patients. Methods The study included 1360 patients
Autor:
Feng-Yan Li, Huan-Xin Lin, San-Gang Wu, Qin Lin, Zhen-Yu He, Xun-Xing Guan, Juan Zhou, Jia-Yuan Sun
Publikováno v:
BMC Cancer
Background The aim of this study was to evaluate the prognostic value of the number of negative lymph nodes (NLNs) in breast cancer patients after mastectomy. Methods 2,455 breast cancer patients who received a mastectomy between January 1998 and Dec
Autor:
Angang Yang, Lin-Tao Jia, Ying Chen, Ting Wang, Lei Wang, Xing-Ming Ye, Huayu Zhu, Wen-Dong Bai
Publikováno v:
BMC Cancer
Background Resistance to humanized monoclonal erbB2/HER2 antibody, trastuzumab (Herceptin), has become a pivotal obstacle for targeted therapy of HER2-positive breast cancers. The activation of alternative growth factor receptors, in particular, the
Autor:
Vania Gloria Silami Lopes, André Vallejo da Silva, Fabiana Resende Rodrigues, Mônica Pureza, Karin Soares Gonçalves Cunha
Publikováno v:
BMC Cancer
Background Neurofibromatosis 1 is one of the most common genetic diseases in humans, presenting with multiple neurofibromas and an increased risk of various benign and malignant tumors, including breast cancer. Case presentation In this paper we repo
Autor:
Christine Naczki, Keith D. Barlow, Linda J. Metheny-Barlow, Wenhong Chen, L. Douglas Case, Mayur Choudhary
Publikováno v:
BMC Cancer
Background Proper functional association between mural cells and endothelial cells (EC) causes EC of blood vessels to become quiescent. Mural cells on tumor vessels exhibit decreased attachment to EC, which allows vessels to be unstable and prolifera
Autor:
Gilbert Spizzo, Marion Zitt, Oliver A. Wrulich, Florian Lehne, Martin Hermann, Sylvia Krobitsch, Guenther Gastl, Johanna M. Gostner, Agnieszka Martowicz, Dominic Fong
Publikováno v:
BMC Cancer
BMC Cancer, Vol 11, Iss 1, p 45 (2011)
BMC Cancer, Vol 11, Iss 1, p 45 (2011)
Background Recently, EpCAM has attracted major interest as a target for antibody- and vaccine-based cancer immunotherapies. In breast cancer, the EpCAM antigen is overexpressed in 30-40% of all cases and this increased expression correlates with poor
Autor:
Romero, Anabel, Torá Rocamora, Isabel, 1979, Baré, Marisa, Barata, Teresa, Domingo, Laia, Ferrer, Joana, Torà, Núria, Comas Serrano, Mercè, Merenciano, Carmen, Macià Guilà, Francesc Assís, Castells, Xavier, Sala, Maria, CAMISS Study Group
Publikováno v:
BMC Cancer
BACKGROUND: To date, the study of the risks and benefits of breast cancer screening has not included the onset of persistent pain after breast cancer treatment within the context of population-based screening programs. Our purpose was to investigate
Autor:
Azza Ben Hamida, Intidhar S Labidi, Emmanuelle Charafe-Jauffret, Patrice Viens, Saïda Ben Arab, Benjamin Esterni, Daniel Birnbaum, Luc Xerri, Karima Mrad, François Bertucci, Jocelyne Jacquemier
Publikováno v:
BMC Cancer
BMC Cancer, BioMed Central, 2008, 8 (1), pp.28. ⟨10.1186/1471-2407-8-28⟩
BMC Cancer, Vol 8, Iss 1, p 28 (2008)
BMC Cancer, BioMed Central, 2008, 8 (1), pp.28. ⟨10.1186/1471-2407-8-28⟩
BMC Cancer, Vol 8, Iss 1, p 28 (2008)
BackgroundInflammatory breast cancer (IBC) is a distinct and aggressive form of locally-advanced breast cancer with high metastatic potential. In Tunisia, IBC is associated with a high death rate. Among the major molecular subtypes, basal breast carc