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Autor:
Timothy M. Pawlik, Kelly K. Hunt, Henry Mark Kuerer, Yanna Liu, Herbert A. Fritsche, David H. Hawke, Savitri Krishnamurthy
Publikováno v:
BMC Cancer, Vol 6, Iss 1, p 68 (2006)
BMC Cancer
BMC Cancer
Background Isotope-coded affinity tag (ICAT) tandem mass spectrometry (MS) allows for qualitative and quantitative analysis of paired protein samples. We sought to determine whether ICAT technology could quantify and identify differential expression
Autor:
Guilhem Bousquet, Nathalie Jourdan, Cathy Pereira, Anne Janin, Diaddin Hamdan, Christophe Leboeuf, Laurence Verneuil
Publikováno v:
BMC Cancer
BMC Cancer, BioMed Central, 2015
BMC Cancer, BioMed Central, 2015
Background Hypereosinophilia, defined by an absolute eosinophil count of more than 1500/mm3, is rarely observed in patients treated for cancer, and rarely imputable to anti-cancer agents. Drug-induced hypereosinophilia usually appears within a few we
Publikováno v:
BMC Cancer
Background Matrix metalloproteases and collagen are key participants in breast cancer, but their precise roles in cancer etiology and progression remain unclear. MMP13 helps regulate collagen structure and has been ascribed largely harmful roles in c
Autor:
Vladislav A. Litosh, Shuangping Zhao, Jonna Frasor, Irida Kastrati, Manuel G. Alvarez, Gregory R. J. Thatcher
Publikováno v:
BMC Cancer
Introduction Activation of cyclooxygenase (COX)/prostaglandin and nuclear factor κB (NFκB) pathways can promote breast tumor initiation, growth, and progression to drug resistance and metastasis. Thus, anti-inflammatory drugs have been widely explo
Autor:
Fountzilas, George, Dafni, U., Bobos, M., Kotoula, V., Batistatou, Anna, Xanthakis, I., Papadimitriou, C., Kostopoulos, I., Koletsa, T., Tsolaki, E., Televantou, D., Timotheadou, E., Koutras, A. K., Klouvas, G. D., Samantas, E., Pisanidis, N., Karanikiotis, C., Sfakianaki, I., Pavlidis, Nicholas, Gogas, H., Linardou, H., Kalogeras, K. T., Pectasides, Dimitrios, Dimopoulos, M. A.
Publikováno v:
BMC Cancer
Background: The HER2 gene has been established as a valid biological marker for the treatment of breast cancer patients with trastuzumab and probably other agents, such as paclitaxel and anthracyclines. The TOP2A gene has been associated with respons
Autor:
Hugo M. Horlings, Meaghan Dendy, Tao Su, Lao H. Saal, Neal Rosen, Matthew Maurer, Ramon Parsons, Lorenzo Memeo, Qing-Bai She, Mervi Jumppanen, Jorma Isola, Ying Ka Ingar Lau, Sofia K. Gruvberger-Saal, Marc J. van de Vijver, Yilun Chen, Hanina Hibshoosh
Publikováno v:
BMC cancer, 16(1). BioMed Central
BMC Cancer
BMC Cancer
The basal-like breast cancer (BLBC) subtype is characterized by positive staining for basal mammary epithelial cytokeratin markers, lack of hormone receptor and HER2 expression, and poor prognosis with currently no approved molecularly-targeted thera
Autor:
Seok Jin Nam, Eun Yoon Cho, Yeonju Kim, Jeong Eon Lee, Young-Hyuck Im, Jong Sun Choi, Sarah Park, Ensel Oh, Yun-Chul Hong, Yoon La Choi, Jung Han Kim, Yeon Hee Park, Young Kee Shin, Kyoung Song, Jung-Hyun Yang
Publikováno v:
BMC Cancer
BMC Cancer, Vol 10, Iss 1, p 507 (2010)
BMC Cancer, Vol 10, Iss 1, p 507 (2010)
Background Triple-negative breast cancers (TNBCs) and basal-like breast cancers (BLBCs) are known as poor outcome subtypes with a lack of targeted therapy. Previous studies have shown conflicting results regarding the difference of prognostic signifi
Autor:
Carla Penner, Leigh C. Murphy, Drew Mulhall, Steven Cooper, Xiuli Ma, Kevin J Dueck, Anne Blanchard, Yvonne Myal, Etienne Leygue
Publikováno v:
BMC Cancer
Background Defects in tight junctions, gate-keepers of the integrity of the epidermal barrier function, are known to contribute to cancer development. As such, enhancing our understanding of how the expression of proteins involved in these junctions
Autor:
Debabrata Mukhopadhyay, Asha S. Nair, Priya Srinivas, Sreelatha K. Hemalatha, Krishnendu Pal, Veena Somasundaram, Sutapa Sinha
Publikováno v:
BMC Cancer
Background Studies over the past decade and half have identified cancer stem cells (CSCs) to be responsible for tumorigenesis, invasion, sustenance of metastatic disease, radio- and chemo-resistance and tumor relapse. Recent reports have described th
Publikováno v:
BMC Cancer, Vol 11, Iss 1, p 490 (2011)
BMC Cancer
BMC Cancer
Background Cowden Syndrome (CS) patients with germ line point mutations in the PTEN gene are at high risk for developing breast cancer. It is believed that cells harboring these mutant PTEN alleles are predisposed to malignant conversion. This articl