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Publikováno v:
BMC Cancer
BMC Cancer, Vol 8, Iss 1, p 153 (2008)
BMC Cancer, Vol 8, Iss 1, p 153 (2008)
Background A number of protein markers have been investigated as prognostic adjuncts in breast cancer but their translation into clinical practice has been impeded by a lack of appropriate validation. Recently, we showed that BCL2 protein expression
Autor:
Claudia Alessandra Andrade de Paula, Debora Okamoto, Sheila Siqueira Andrade, Mariana Cristina Cabral Silva, Lilian Caroline Gonçalves de Oliveira, Maria Luiza Vilela Oliva, Gil Facina, Giovani B. Peres, Ismael Dale Cotrim Guerreiro da Silva, Tatiana F. Ottaiano, Eloísa Dognani Castro, Antonio Campos, Afonso Celso Pinto Nazário, Edgar J. Paredes-Gamero, Manoel João Batista Castello Girão, Maria A. Juliano, Iuri E. Gouvea
Publikováno v:
BMC Cancer
Background Breast cancer comprises clinically and molecularly distinct tumor subgroups that differ in cell histology and biology and show divergent clinical phenotypes that impede phase III trials, such as those utilizing cathepsin K inhibitors. Here
Autor:
Yoko Nakasu, Koichi Mitsuya, Nakamasa Hayashi, Junichiro Watanabe, Hideyuki Harada, Ichiro Ito
Publikováno v:
BMC Cancer
Background Multiple new targeted agents have been developed for patients with human epidermal growth factor receptor type 2 (HER2) – positive breast cancer. Patients with HER2– positive breast cancer will develop brain metastases with greater inc
Publikováno v:
BMC Cancer
Background Monoclonal antibodies have been used to effectively treat various tumors. We previously established a unique strategy to identify tumor specific antibodies by capturing B-cell response against breast tumor antigens from patient-derived sen
Publikováno v:
BMC Cancer
Background Dermatomyositis is an autoimmune myopathy characterized by proximal muscle weakness, muscle inflammation, and typical skin findings. It is a rare disease with an incidence of ~1/100 000. About 15–30 % of adult-onset cases are caused by u
Autor:
Christian F. Singer, Dietmar Pils, Dan Tong, Andrea Wolf, Margaretha Rudas, Gerda Hofstetter, Ingrid Schiebel, Nicole Concin, Georg Heinze, Robert Zeillinger
Publikováno v:
BMC Cancer, Vol 10, Iss 1, p 682 (2010)
BMC Cancer
BMC Cancer
Background Gene expression of peripheral myelin protein 22 (PMP22) and the epithelial membrane proteins (EMPs) was found to be differentially expressed in invasive and non-invasive breast cell lines in a previous study. We want to evaluate the progno
Autor:
Karin Jirström, Donal J. Brennan, William M. Gallagher, Elton Rexhepaj, Michael J. Duffy, Darran P. O'Connor, Sallyann L. O'Brien, Göran Landberg
Publikováno v:
BMC Cancer
BMC Cancer; 10 (2010)
BMC Cancer, Vol 10, Iss 1, p 639 (2010)
BMC Cancer; 10 (2010)
BMC Cancer, Vol 10, Iss 1, p 639 (2010)
Background Conflicting data exist regarding the prognostic and predictive impact of survivin (BIRC5) in breast cancer. We previously reported survivin cytoplasmic-to-nuclear ratio (CNR) as an independent prognostic indicator in breast cancer. Here, w
Autor:
Yurong Ou, Yanling Zhang, Donghong Yu, Bo Zhu, Zenong Cheng, Lei Zhou, Qiong Zhang, Xiang Yong, Xiaoli Wang, Zhaogen Cai
Publikováno v:
BMC Cancer
BACKGROUND: Centrally necrotizing carcinoma of the breast (CNC) represents a newly-identified subset of breast cancer. The clinical and pathological characteristics of this breast cancer subtype are not yet completely understood. METHODS: We assessed
Autor:
Chiara Campanella, Monica Gatti, Tullio Florio, Valeria Marini, Aldo Pagano, Guendalina Vito, Antonio Daga, Alessandra Pattarozzi, Alessandra Ratto, Francesca Mattioli, Adriana Bajetto, Roberto Würth, Carmen Fucile, Angelo Ferrari, Federica Barbieri, Elisa Carra, Stefano Thellung
Publikováno v:
BMC Cancer
Background Cancer stem cells (CSCs) are considered the cell subpopulation responsible for breast cancer (BC) initiation, growth, and relapse. CSCs are identified as self-renewing and tumor-initiating cells, conferring resistance to chemo- and radio-t
Autor:
William W. West, R Thompson, Rajesh R. Kulkarni, Sanjay Muttineni, Edibaldo Silva-Lopez, Vivek Verma
Publikováno v:
BMC Cancer
Background Signs and symptoms of a rapidly enlarging breast mass are not only important for all clinicians to recognize and assess, but also are not uncommon occurrences. We describe a similar but unique case that developed into an enormous, 36 cm ex