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pro vyhledávání: ''
Autor:
Anupam Batra, C. Michael DiPersio, Anshu Aggarwal, David M. Jones, Rami N. Al-Rohil, Paul J. Feustel
Publikováno v:
BMC Cancer
Background Expression of integrin α3β1 is associated with tumor progression, metastasis, and poor prognosis in several cancers, including breast cancer. Moreover, preclinical studies have revealed important pro-tumorigenic and pro-metastatic functi
Publikováno v:
BMC Cancer
BMC CANCER(13)
BMC CANCER(13)
Background Heregulin (HRG; also known as neuregulin) is a ligand for ErbB3. One of its isotypes, HRG-β1, binds to ErbB3 and forms heterodimers with other ErbB family members, thereby enhancing the proliferation and tumorigenesis of breast cancer cel
Autor:
Nicole Lavender, Jiqing Sai, Ann Richmond, Philip Owens, Jinming Yang, C. Andrew Johnson, Gregory D. Ayers, Sheau-Chiann Chen
Publikováno v:
BMC Cancer
Background The role of the chemokine CCL2 in breast cancer is controversial. While CCL2 recruits and activates pro-tumor macrophages, it is also reported to enhance neutrophil-mediated anti-tumor activity. Moreover, loss of CCL2 in early development
Autor:
Adrienne Morey, Diana J. Hastrich, David Ingram, Peter C. Willsher, Arlene Chan, Belinda Brown
Publikováno v:
BMC Cancer, Vol 12, Iss 1, p 555 (2012)
BMC Cancer
BMC Cancer
Background Overall survival of HER2 positive metastatic breast cancer patients has been significantly improved with inclusion of trastuzumab to chemotherapy. Several studies have demonstrated discordant HER2 status in the primary and metastatic tumou
Autor:
Gina Bouchard, Yves Bérubé-Lauzière, Hélène Therriault, Sameh Geha, Rachel Bujold, Caroline Saucier, Benoit Paquette
Publikováno v:
BMC Cancer
Background Some triple negative breast cancer (TNBC) patients are at higher risk of recurrence in the first three years after treatment. This rapid relapse has been suggested to be associated with inflammatory mediators induced by radiation in health
Publikováno v:
BMC Cancer
Background Histologically similar tumors even from the same anatomical position may still show high variability at molecular level hindering analysis of genome-wide data. Leveling the analysis to a gene regulatory network instead of focusing on singl
Autor:
Ari T Vaara, Aaron S. Mansfield, Jukka Vakkila, Päivi Heikkilä, Karl von Smitten, Marjut Leidenius
Publikováno v:
BMC Cancer, Vol 9, Iss 1, p 231 (2009)
BMC Cancer
BMC Cancer
Background There is evidence that the immune systems of patients with breast cancer are dysfunctional. Regulatory T cells (Tregs), and IDO, an immunosuppressive enzyme, are associated with more advanced disease in some cancers and may promote immunol
Autor:
David D. Sampson, Brendan F. Kennedy, Christobel Saunders, Bruce Latham, Robert A. McLaughlin, Kelsey M. Kennedy, Lixin Chin, Philip Wijesinghe
Publikováno v:
BMC Cancer
This project is supported with funding from the Australian Research Council; and Cancer Council WA, which allowed us to develop the technology; Department of Health of Western Australia, National Breast Cancer Foundation (Australia); and the National
Autor:
Carlos Caldas, Sergio Gómez, Mathias Gehrmann, Marcus Schmidt, Dorraya El-Ashry, Alex Arenas, Andrew E. Teschendorff
Publikováno v:
BMC Cancer, 10, Article 604. (2010)
BMC Cancer
BMC Cancer, Vol 10, Iss 1, p 604 (2010)
BMC Cancer
BMC Cancer, Vol 10, Iss 1, p 604 (2010)
Background Elucidating the activation pattern of molecular pathways across a given tumour type is a key challenge necessary for understanding the heterogeneity in clinical response and for developing novel more effective therapies. Gene expression si
Autor:
Leticia Labriola, Mari Cleide Sogayar, Luciana Rodrigues Gomes, Rosângela A. M Wailemann, Letícia Ferreira Terra
Publikováno v:
BMC Cancer, Vol 12, Iss 1, p 26 (2012)
BMC Cancer
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
BMC Cancer
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Background Metastasis is the main factor responsible for death in breast cancer patients. Matrix metalloproteinases (MMPs) and their inhibitors, known as tissue inhibitors of MMPs (TIMPs), and the membrane-associated MMP inhibitor (RECK), are essenti