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Autor:
Anupam Batra, C. Michael DiPersio, Anshu Aggarwal, David M. Jones, Rami N. Al-Rohil, Paul J. Feustel
Publikováno v:
BMC Cancer
Background Expression of integrin α3β1 is associated with tumor progression, metastasis, and poor prognosis in several cancers, including breast cancer. Moreover, preclinical studies have revealed important pro-tumorigenic and pro-metastatic functi
Autor:
Taher Al-Tweigeri, Ayodele Alaiya, Abdelilah Aboussekhra, Nujoud Al-Yousef, Suad M. Bin Amer, Nisreen Al-Moghrabi, Safia Madkhali, Asma Tulbah, Asmaa Nofel, Zakia Shinwari, Bedri Karakas
Publikováno v:
BMC Cancer
Background BRCA1 promoter methylation has been detected in DNA from peripheral blood cells of both breast cancer patients and cancer-free females. However, the pathological significance of this epigenetic change in white blood cells (WBC) remains an
Publikováno v:
BMC Cancer
Background Although mammary microcalcification is frequently observed and has been associated with poor survival in patients with breast cancer, the genesis of calcification remains unclear. Carbonic anhydrase I (CA1) has been shown to promote calcif
Autor:
Christian F. Singer, Dietmar Pils, Dan Tong, Andrea Wolf, Margaretha Rudas, Gerda Hofstetter, Ingrid Schiebel, Nicole Concin, Georg Heinze, Robert Zeillinger
Publikováno v:
BMC Cancer, Vol 10, Iss 1, p 682 (2010)
BMC Cancer
BMC Cancer
Background Gene expression of peripheral myelin protein 22 (PMP22) and the epithelial membrane proteins (EMPs) was found to be differentially expressed in invasive and non-invasive breast cell lines in a previous study. We want to evaluate the progno
Publikováno v:
BMC Cancer, Vol 12, Iss 1, p 380 (2012)
BMC Cancer
BMC Cancer
Background Tumor development is known to be a stepwise process involving dynamic changes that affect cellular integrity and cellular behavior. This complex interaction between genomic organization and gene, as well as protein expression is not yet fu
Autor:
Brian V. Lananna, Raymond J. Louie, Denise A. Chan, Mercè Padró, Adam J. Krieg, Luika A. Timmerman
Publikováno v:
BMC Cancer
Background About 75–80% of breast tumors express the estrogen receptor alpha (ER-α) and are treated with endocrine-target therapeutics, making this the premier therapeutic modality in the breast cancer clinic. However, acquired resistance is commo
Autor:
Carlos Caldas, Sergio Gómez, Mathias Gehrmann, Marcus Schmidt, Dorraya El-Ashry, Alex Arenas, Andrew E. Teschendorff
Publikováno v:
BMC Cancer, 10, Article 604. (2010)
BMC Cancer
BMC Cancer, Vol 10, Iss 1, p 604 (2010)
BMC Cancer
BMC Cancer, Vol 10, Iss 1, p 604 (2010)
Background Elucidating the activation pattern of molecular pathways across a given tumour type is a key challenge necessary for understanding the heterogeneity in clinical response and for developing novel more effective therapies. Gene expression si
Autor:
Brittany Singleton, Shawn D. Llopis, Tamika Duplessis, Brian G. Rowan, Christopher Williams, Latonya Carrier
Publikováno v:
BMC Cancer
Background NR4A orphan nuclear receptors are involved in multiple biological processes which are important in tumorigenesis such as cell proliferation, apoptosis, differentiation, and glucose utilization. The significance of NR4A family member NURR1
Autor:
Rajkumar Lakshmanaswamy, Dianne C. Mitchell, Clarissa N. Amaya, Vittal Kurisetty, Alice M. Nyakeriga, Arunkumar Arumugam, Jessica M. Stiles, Cristian E. Botez, Brad A. Bryan
Publikováno v:
BMC Cancer
Background Preclinical and clinical studies have shown for decades that tumor cells demonstrate significantly enhanced sensitivity to “fever range” hyperthermia (increasing the intratumoral temperature to 42-45°C) than normal cells, although it
Autor:
Mathias Krockenberger, Michaela Kapp, Arnd Honig, Lorenz Rieger, Matthias Eck, Ulrike Kämmerer, Johannes Dietl
Publikováno v:
BMC Cancer, Vol 6, Iss 1, p 199 (2006)
BMC Cancer
BMC Cancer
Background Tartrate-resistant acid phosphatase (TRAP) is a metalloprotein enzyme that belongs to the acid phosphatases and is known to be expressed by osteoclasts. It has already been investigated as a marker of bone metastases in cancer patients. In