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Autor:
Taher Al-Tweigeri, Ayodele Alaiya, Abdelilah Aboussekhra, Nujoud Al-Yousef, Suad M. Bin Amer, Nisreen Al-Moghrabi, Safia Madkhali, Asma Tulbah, Asmaa Nofel, Zakia Shinwari, Bedri Karakas
Publikováno v:
BMC Cancer
Background BRCA1 promoter methylation has been detected in DNA from peripheral blood cells of both breast cancer patients and cancer-free females. However, the pathological significance of this epigenetic change in white blood cells (WBC) remains an
Autor:
Claire Josse, Vincent Bours, Pierre Frères, Guy Jerusalem, Bouchra Boujemla, Stephane Wenric, Karin Segers, Raphaël Marée, Joëlle Collignon, Meriem Boukerroucha, Sonia ElGuendi
Publikováno v:
BMC Cancer
Background The BRCA1 gene plays a key role in triple negative breast cancers (TNBCs), in which its expression can be lost by multiple mechanisms: germinal mutation followed by deletion of the second allele; negative regulation by promoter methylation
Publikováno v:
BMC Cancer
BMC CANCER(13)
BMC CANCER(13)
Background Heregulin (HRG; also known as neuregulin) is a ligand for ErbB3. One of its isotypes, HRG-β1, binds to ErbB3 and forms heterodimers with other ErbB family members, thereby enhancing the proliferation and tumorigenesis of breast cancer cel
Autor:
Nicole Lavender, Jiqing Sai, Ann Richmond, Philip Owens, Jinming Yang, C. Andrew Johnson, Gregory D. Ayers, Sheau-Chiann Chen
Publikováno v:
BMC Cancer
Background The role of the chemokine CCL2 in breast cancer is controversial. While CCL2 recruits and activates pro-tumor macrophages, it is also reported to enhance neutrophil-mediated anti-tumor activity. Moreover, loss of CCL2 in early development
Publikováno v:
BMC Cancer
Background Although mammary microcalcification is frequently observed and has been associated with poor survival in patients with breast cancer, the genesis of calcification remains unclear. Carbonic anhydrase I (CA1) has been shown to promote calcif
Publikováno v:
BMC Cancer
Background Monoclonal antibodies have been used to effectively treat various tumors. We previously established a unique strategy to identify tumor specific antibodies by capturing B-cell response against breast tumor antigens from patient-derived sen
Publikováno v:
BMC Cancer
© 2017 The Author(s). Background: Breast cancer is the most frequently diagnosed cancer in women. Resident macrophages at distant sites provide a highly responsive and immunologically dynamic innate immune response against foreign infiltrates. Despi
Publikováno v:
BMC Cancer
Background Breast cancer is one of the most deadly diseases in women. Inhibiting the synthesis of estrogen is effective in treating patients with estrogen-responsive breast cancer. Previous studies have demonstrated that use of cyclooxygenase (COX) i
Autor:
Kaouther Snoussi, Wijden Mahfoudh, Meriem Fekih, Ahmed Noureddine Helal, Hedi Khairi, Lotfi Chouchane, Noureddine Bouaouina
Publikováno v:
BMC Cancer, Vol 10, Iss 1, p 283 (2010)
BMC Cancer
BMC Cancer
Background Interleukin-8 (IL-8/CXCL-8) is a prototype of the ELR+CXC chemokines that play an important role in the promotion and progression of many human cancers including breast cancer. We have recently showed the implication of polymorphism (-251)
Autor:
Chiara Campanella, Monica Gatti, Tullio Florio, Valeria Marini, Aldo Pagano, Guendalina Vito, Antonio Daga, Alessandra Pattarozzi, Alessandra Ratto, Francesca Mattioli, Adriana Bajetto, Roberto Würth, Carmen Fucile, Angelo Ferrari, Federica Barbieri, Elisa Carra, Stefano Thellung
Publikováno v:
BMC Cancer
Background Cancer stem cells (CSCs) are considered the cell subpopulation responsible for breast cancer (BC) initiation, growth, and relapse. CSCs are identified as self-renewing and tumor-initiating cells, conferring resistance to chemo- and radio-t