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Publikováno v:
BMC Cancer
Background A signal transduction pathway (STP) is a network of intercellular information flow initiated when extracellular signaling molecules bind to cell-surface receptors. Many aberrant STPs have been associated with various cancers. To develop op
Autor:
Riikka Nurminen, Johanna Schleutker, Heli Nevanlinna, Liisa M. Pelttari, Lauri A. Aaltonen, Alexandra E. Gylfe
Publikováno v:
BMC Cancer, Vol 12, Iss 1, p 552 (2012)
BMC Cancer
BMC Cancer
Background Rare, heterozygous germline mutations in the RAD51C gene have been found in breast and ovarian cancer families. In the Finnish population, we have identified two founder mutations in RAD51C that increase the risk of ovarian cancer but not
Publikováno v:
BMC Cancer, Vol 10, Iss 1, p 228 (2010)
BMC Cancer
BMC Cancer
Background The 2007 St Gallen international expert consensus statement describes three risk categories and provides recommendations for treatment of early breast cancer. The set of recommendations on how to best treat primary breast cancer is recogni
Publikováno v:
BMC Cancer
Background Histologically similar tumors even from the same anatomical position may still show high variability at molecular level hindering analysis of genome-wide data. Leveling the analysis to a gene regulatory network instead of focusing on singl
Autor:
Auli Karhu, Pia Alhopuro, Kati K. Waltering, Lauri A. Aaltonen, Robert Winqvist, Tapio Visakorpi
Publikováno v:
BMC Cancer, Vol 8, Iss 1, p 263 (2008)
BMC Cancer
BMC Cancer
Background MYH11 (also known as SMMHC) encodes the smooth-muscle myosin heavy chain, which has a key role in smooth muscle contraction. Inversion at the MYH11 locus is one of the most frequent chromosomal aberrations found in acute myeloid leukemia.
Autor:
Nathanael S. Gray, Edwin Choy, Gregory M. Cote, Zhenfeng Duan, Francis J. Hornicek, Yingqi Hua, David C. Harmon, Yu Zhang, Jianming Zhang, Jacson Shen, Shunan Ye, Henry J. Mankin
Publikováno v:
BMC cancer, vol 14, iss 1
BMC Cancer
BMC Cancer
Background Reversing multidrug resistance (MDR) has been an important goal for clinical and investigational oncologists. In the last few decades, significant effort has been made to search for inhibitors to reverse MDR by targeting ATP-binding casset
Autor:
Geoffrey L. Greene, Lucy Xia, Laurence N. Kolonel, Michael R. Stallcup, Michael F. Press, Chris Hsu, Helen Ha, Christopher A. Haiman, Brian E. Henderson, Loic Le Marchand, Rachel R Garcia, Xin Sheng
Publikováno v:
BMC Cancer
BMC Cancer, Vol 9, Iss 1, p 43 (2009)
BMC Cancer, Vol 9, Iss 1, p 43 (2009)
Background Only a limited number of studies have performed comprehensive investigations of coding variation in relation to breast cancer risk. Given the established role of estrogens in breast cancer, we hypothesized that coding variation in steroid
Autor:
Guilhem Bousquet, Nathalie Jourdan, Cathy Pereira, Anne Janin, Diaddin Hamdan, Christophe Leboeuf, Laurence Verneuil
Publikováno v:
BMC Cancer
BMC Cancer, BioMed Central, 2015
BMC Cancer, BioMed Central, 2015
Background Hypereosinophilia, defined by an absolute eosinophil count of more than 1500/mm3, is rarely observed in patients treated for cancer, and rarely imputable to anti-cancer agents. Drug-induced hypereosinophilia usually appears within a few we
Publikováno v:
BMC Cancer
Background Matrix metalloproteases and collagen are key participants in breast cancer, but their precise roles in cancer etiology and progression remain unclear. MMP13 helps regulate collagen structure and has been ascribed largely harmful roles in c
Publikováno v:
BMC Cancer, Vol 11, Iss 1, p 490 (2011)
BMC Cancer
BMC Cancer
Background Cowden Syndrome (CS) patients with germ line point mutations in the PTEN gene are at high risk for developing breast cancer. It is believed that cells harboring these mutant PTEN alleles are predisposed to malignant conversion. This articl