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Autor:
Claudia Alessandra Andrade de Paula, Debora Okamoto, Sheila Siqueira Andrade, Mariana Cristina Cabral Silva, Lilian Caroline Gonçalves de Oliveira, Maria Luiza Vilela Oliva, Gil Facina, Giovani B. Peres, Ismael Dale Cotrim Guerreiro da Silva, Tatiana F. Ottaiano, Eloísa Dognani Castro, Antonio Campos, Afonso Celso Pinto Nazário, Edgar J. Paredes-Gamero, Manoel João Batista Castello Girão, Maria A. Juliano, Iuri E. Gouvea
Publikováno v:
BMC Cancer
Background Breast cancer comprises clinically and molecularly distinct tumor subgroups that differ in cell histology and biology and show divergent clinical phenotypes that impede phase III trials, such as those utilizing cathepsin K inhibitors. Here
Autor:
Nicole Lavender, Jiqing Sai, Ann Richmond, Philip Owens, Jinming Yang, C. Andrew Johnson, Gregory D. Ayers, Sheau-Chiann Chen
Publikováno v:
BMC Cancer
Background The role of the chemokine CCL2 in breast cancer is controversial. While CCL2 recruits and activates pro-tumor macrophages, it is also reported to enhance neutrophil-mediated anti-tumor activity. Moreover, loss of CCL2 in early development
Autor:
Sandra Salvi, Pier Vitale Nuzzo, L. Zinoli, Francesco Boccardo, Simona Boccardo, Alessandra Rubagotti
Publikováno v:
BMC Cancer
Background PN is a secreted cell adhesion protein critical for carcinogenesis. In breast cancer, it is overexpressed compared to normal breast, and a few reports suggest that it has a potential role as a prognostic marker. Methods Tumour samples obta
Publikováno v:
BMC Cancer
© 2017 The Author(s). Background: Breast cancer is the most frequently diagnosed cancer in women. Resident macrophages at distant sites provide a highly responsive and immunologically dynamic innate immune response against foreign infiltrates. Despi
Autor:
Gina Bouchard, Yves Bérubé-Lauzière, Hélène Therriault, Sameh Geha, Rachel Bujold, Caroline Saucier, Benoit Paquette
Publikováno v:
BMC Cancer
Background Some triple negative breast cancer (TNBC) patients are at higher risk of recurrence in the first three years after treatment. This rapid relapse has been suggested to be associated with inflammatory mediators induced by radiation in health
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-13 (2017)
BMC Cancer, 17(232). BMC
BMC Cancer
BMC Cancer, 17(232). BMC
BMC Cancer
Background Clinical efficacy of the mTOR inhibitor everolimus is limited in breast cancer and regularly leads to side-effects including hyperglycemia. The AMPK inhibitor and anti-diabetic drug metformin may counteract everolimus-induced hyperglycemia
Autor:
José Esparza-López, Alejandro Zentella-Dehesa, Pier Ramos-Elias, Leticia Rocha-Zavaleta, Elizabeth Escobar-Arriaga, María de Jesús Ibarra-Sánchez, Eucario León-Rodríguez, Andrea Castro-Sanchez, Heriberto Medina-Franco
Publikováno v:
BMC Cancer
Background It has become evident that intra-tumor heterogeneity of breast cancer impact on several biological processes such as proliferation, migration, cell death and also might contribute to chemotherapy resistance. The expression of Receptor Tyro
Autor:
Like Qu, Caiyun Liu, Jianping Guo, Li Min, Chengchao Shou, Xiaofan Li, Yihao Li, Hua Yuan, Cheng Zhang, Ruolan Ma, Ruxuan Chen
Publikováno v:
BMC Cancer
Background Although radiotherapy following mastectomy was demonstrated to reduce the recurring risk and improve the prognosis of patients with breast cancer, it is also notorious for comprehensive side effects, hence only a selected group of patients
Autor:
Anita Bane, Amy Gillgrass, Kay Dias, John A. Hassell, Mark Levine, Robin M. Hallett, Jessica G. Cockburn, Timothy J. Whelan
Publikováno v:
BMC Cancer
Background Lymph node (LN) status is the most important prognostic variable used to guide ER positive (+) breast cancer treatment. While a positive nodal status is traditionally associated with a poor prognosis, a subset of these patients respond wel
Autor:
Lauren M. Zasadil, Mark E. Burkard, Beth A. Weaver, Jennifer Laffin, Ryan A. Denu, Craig Kanugh
Publikováno v:
BMC Cancer
Background Centrosome amplification (CA) has been reported in nearly all types of human cancer and is associated with deleterious clinical factors such as higher grade and stage. However, previous reports have not shown how CA affects cellular differ