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Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-11 (2021)
BMC Cancer
BMC Cancer
Background Eukaryotic translation initiation factors (eIFs) are the key factors to synthesize translation initiation complexes during the synthesis of eukaryotic proteins. Besides, eIFs are especially important in regulating the immune function of tu
Autor:
Hiroshi Wada, Masayoshi Yasui, Keijiro Sugimura, Hiroshi Miyata, Norikatsu Miyoshi, Takeshi Omori, Chu Matsuda, Masayuki Ohue, Hidenori Takahashi, Shingo Noura, Naotsugu Haraguchi, Shiki Fujino, Nozomu Nakai, Yusuke Takahashi, Junichi Nishimura, Hajime Ushigome
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-8 (2021)
BMC Cancer
BMC Cancer
BackgroundTotal mesorectal excision (TME) and lateral lymph node dissection (LLND) without radiotherapy (RT) are standard treatment for lower cT3/4 rectal cancers in Eastern countries. In comparative studies, both TME + LLND and RT + TME yield good l
Novel meso-substituted porphyrin derivatives and its potential use in photodynamic therapy of cancer
Autor:
Gustavo Hernán Calvo, Pablo Vallecorsa, Daniel A. Sáenz, M. Belén Ballatore, Edgardo N. Durantini, Gabriela Di Venosa, Darío D. Ferreyra, Adriana Casas, Leandro Mamone
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-12 (2021)
BMC Cancer
BMC Cancer
Background Photodynamic therapy (PDT) is an anticancer treatment that utilizes the interaction of light and a photosensitiser (PS), promoting tumour cell death mediated by generation of reactive oxygen species. In this study, we evaluated the in vitr
Autor:
Broderick J. House, Scott C. Davis, Jasmin M. Schaefer, Marcus J. Kwon, Summer L. Gibbs, Connor W. Barth, Allison Solanki
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-9 (2021)
BMC Cancer
BMC Cancer
Background Re-excision rates following breast conserving surgery (BCS) remain as high as ~ 35%, with positive margins detected during follow-up histopathology. Additional breast cancer resection surgery is not only taxing on the patient and health ca
Autor:
Martha M. Grimes, Yuna Guo, Dayna Dominguez, Laurie G. Hudson, Angela Wandinger-Ness, Kathryn J. Brayer, S. Ray Kenney
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-16 (2021)
BMC Cancer
BMC Cancer
Background Rho-family GTPases, including Ras-related C3 botulinum toxin substrate 1 (Rac1) and cell division control protein 42 (Cdc42), are important modulators of cancer-relevant cell functions and are viewed as promising therapeutic targets. Based
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-10 (2020)
BMC Cancer
BMC Cancer
Zoledronic acid (ZA) is one of the most important and effective class of anti-resorptive drug available among bisphosphonate (BP), which could effectively reduce the risk of skeletal-related events, and lead to a treatment paradigm for patients with
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-14 (2020)
BMC Cancer
BMC Cancer
Background The effect of brachytherapy on lymphocytes and cytokines in the tumor microenvironment is unclear. This study aimed to analyze the relationship between the invasion of lymphocytes and cytokines in the tumor microenvironment and the interva
Autor:
Abeer A. Almiman, Julian Ramelow, Christopher Brooks, Miguel A. Villalona-Calero, Terence M. Williams, Wenrui Duan, Li Gao
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-10 (2020)
BMC Cancer
BMC Cancer
Background Lung cancer is the number one cancer killer worldwide. A major drawback in the lung cancer treatment field is the lack of realistic mouse models that replicate the complexity of human malignancy and immune contexture within the tumor micro
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-11 (2019)
BMC Cancer
BMC Cancer
Background Pancreatic cancer is characterized by a highly immunosuppressive tumor microenvironment and evasion of immune surveillance. Although programmed cell death 1 receptor (PD-1) blockade has achieved certain success in immunogenic cancers, the
Autor:
Angelo Sparaneo, Reza Bayat Mokhtari, Sushil Kumar, Herman Yeger, Narges Baluch, Evgeniya Morgatskaya, Hai Ling Cheng, Sheyun Zhao, Bikul Das, Lucia Anna Muscarella
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-19 (2019)
BMC Cancer
BMC Cancer
Background Bronchial carcinoids are neuroendocrine tumors that present as typical (TC) and atypical (AC) variants, the latter being more aggressive, invasive and metastatic. Studies of tumor initiating cell (TIC) biology in bronchial carcinoids has b