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Autor:
Afroz S. Mohammad, Jessica Griffith, Chris E. Adkins, Neal Shah, Rawaa Aljammal, Katherine L. Jarrell, Rachel M. Tallman, Paul R. Lockman
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-10 (2018)
BMC Cancer
BMC Cancer
Background Brain tumor vasculature can be significantly compromised and leakier than that of normal brain blood vessels. Little is known if there are vascular permeability alterations in the brain adjacent to tumor (BAT). Changes in BAT permeability
Autor:
Lian-zhou Chen, Jiong Bi, Guangqi Chang, Longjuan Zhang, Jieyi Ma, Chen Yao, Wenjian Wang, Yue Liu, Weiming Lv, Mao Ouyang, Shenming Wang, Yuanhui Lai, Jie Li
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-13 (2017)
BMC Cancer
BMC Cancer
Background Triple-negative breast cancer (TNBC) is the malignancy with the worst outcome among all breast cancer subtypes. We reported that ETV1 is a significant oncogene in TNBC tumourigenesis. Consequently, investigating the critical regulatory mic
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-6 (2017)
BMC Cancer
BMC Cancer
Background The increasing incidence and poor outcome associated with malignant pleural effusion (MPE) requires finding an effective treatment for this disease. Inhibitory B7-H4 is expressed in many different human cancers but its role in malignant pl
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-11 (2017)
BMC Cancer
BMC Cancer
Background Recent studies suggested that cancer stem-like cells contribute to tumor vasculogenesis by differentiating into endothelial cells. However, such process is governed by still undefined mechanism. Methods At varying differentiation levels, t
Autor:
Qiusha Tang, Daozhen Chen
Publikováno v:
BMC Cancer, Vol 10, Iss 1, p 609 (2010)
BMC Cancer
BMC Cancer
Background To evaluate the killing effect of HSV-TK/GCV suicide gene therapy system combined with 60Co radiotherapy on human cervical cancer Hela cell line in vitro and in vivo, and to explore the radiosensitization by HSV-TK/GCV system. Methods HSV-
Autor:
Charles N. Pegram, Gregory J. Riggins, Carol J. Wikstrand, Scott E. Szafranski, Ahmed Rasheed, Chien-Tsun Kuan, Darell D. Bigner, Kenji Wakiya, James E. Herndon, Eric S. Lipp, Roger E. McLendon
Publikováno v:
BMC Cancer, Vol 10, Iss 1, p 468 (2010)
BMC Cancer
BMC Cancer
Background Glioblastoma multiforme (GBM) is refractory to conventional therapies. To overcome the problem of heterogeneity, more brain tumor markers are required for prognosis and targeted therapy. We have identified and validated a promising molecul
Autor:
Markus M. Lerch, Anne K. Lagendijk, Frank Ulrich Weiss, Claudia Nitsche, Danielle H. Vlecken, Lars Ivo Partecke, Jeroen Bakkers, Christoph P. Bagowski, Claus-Dieter Heidecke, Ines J. Marques
Publikováno v:
BMC Cancer, Vol 9, Iss 1, p 128 (2009)
BMC Cancer, 9. BioMed Central
BMC Cancer
BMC Cancer, 9. BioMed Central
BMC Cancer
Background Aberrant regulation of cell migration drives progression of many diseases, including cancer cell invasion and metastasis formation. Analysis of tumour invasion and metastasis in living organisms to date is cumbersome and involves difficult
Autor:
Martha Maria Gebhard, Axel Sckell, Peter E. Huber, Volker Ewerbeck, Amir Abdollahi, Frank M. Klenke
Publikováno v:
BMC Cancer, Vol 6, Iss 1, p 9 (2006)
BMC Cancer
Klenke, Frank Michael; Gebhard, Martha-Maria; Ewerbeck, Volker; Abdollahi, Amir; Huber, Peter E; Sckell, Axel (2006). The selective Cox-2 inhibitor Celecoxib suppresses angiogenesis and growth of secondary bone tumors: an intravital microscopy study in mice. BMC cancer, 6, p. 9. London: BioMed Central 10.1186/1471-2407-6-9
BMC Cancer
Klenke, Frank Michael; Gebhard, Martha-Maria; Ewerbeck, Volker; Abdollahi, Amir; Huber, Peter E; Sckell, Axel (2006). The selective Cox-2 inhibitor Celecoxib suppresses angiogenesis and growth of secondary bone tumors: an intravital microscopy study in mice. BMC cancer, 6, p. 9. London: BioMed Central 10.1186/1471-2407-6-9
BackgroundThe inhibition of angiogenesis is a promising strategy for the treatment of malignant primary and secondary tumors in addition to established therapies such as surgery, chemotherapy, and radiation. There is strong experimental evidence in p