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Autor:
Donald T. T. Yapp, Dawn Waterhouse, Dana Masin, Marcel B. Bally, Dita Strutt, Malathi Anantha, Andrew Yung, Maite Verreault, Piotr Kozlowski
Publikováno v:
BMC Cancer, Vol 11, Iss 1, p 124 (2011)
BMC Cancer
BMC Cancer
Background Chemotherapy for glioblastoma (GBM) patients is compromised in part by poor perfusion in the tumor. The present study evaluates how treatment with liposomal formulation of irinotecan (Irinophore C™), and other liposomal anticancer drugs,
Autor:
Charles N. Pegram, Gregory J. Riggins, Carol J. Wikstrand, Scott E. Szafranski, Ahmed Rasheed, Chien-Tsun Kuan, Darell D. Bigner, Kenji Wakiya, James E. Herndon, Eric S. Lipp, Roger E. McLendon
Publikováno v:
BMC Cancer, Vol 10, Iss 1, p 468 (2010)
BMC Cancer
BMC Cancer
Background Glioblastoma multiforme (GBM) is refractory to conventional therapies. To overcome the problem of heterogeneity, more brain tumor markers are required for prognosis and targeted therapy. We have identified and validated a promising molecul
Autor:
Markus M. Lerch, Anne K. Lagendijk, Frank Ulrich Weiss, Claudia Nitsche, Danielle H. Vlecken, Lars Ivo Partecke, Jeroen Bakkers, Christoph P. Bagowski, Claus-Dieter Heidecke, Ines J. Marques
Publikováno v:
BMC Cancer, Vol 9, Iss 1, p 128 (2009)
BMC Cancer, 9. BioMed Central
BMC Cancer
BMC Cancer, 9. BioMed Central
BMC Cancer
Background Aberrant regulation of cell migration drives progression of many diseases, including cancer cell invasion and metastasis formation. Analysis of tumour invasion and metastasis in living organisms to date is cumbersome and involves difficult
Autor:
Luca Cucullo, Damir Janigro, Mukesh K. Agarwal, Vincent Fazio, Kerri L. Hallene, Catalin Perju, Gabriele Dini
Publikováno v:
BMC Cancer, Vol 6, Iss 1, p 72 (2006)
BMC Cancer
BMC Cancer
Background Tumor burden can be pharmacologically controlled by inhibiting cell division and by direct, specific toxicity to the cancerous tissue. Unfortunately, tumors often develop intrinsic pharmacoresistance mediated by specialized drug extrusion