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Autor:
Narayanan Geetha, Ramachandran Krishna Chandran, Raveendran Suresh Kumar, Kumarapillai Mohanan Nair Jagathnath Krishna, Kunnathur Murugesan Sakthivel, Hariharan Sreedharan
Publikováno v:
Blood Cells, Molecules, and Diseases. 77:51-60
The molecular mechanisms responsible for disease progression of CML are not conclusive. The main functional changes associated with disease evolution in CML was high proliferation rate, decreased apoptosis, blockade of differentiation, and strong res
Autor:
Anne Bouvier, Valérie Ugo, Anaïse Blouet, Alain Zannetti, Mathilde Hunault-Berger, Matgorzata Truchan-Graczyk, Jérémie Riou, Damien Luque Paz, Odile Blanchet, Laurane Cottin, Annaëlle Beucher, Corentin Orvain, Françoise Boyer, Rébecca Jouanneau-Courville, Bénédicte Ribourtout
Publikováno v:
Blood Cells, Molecules and Diseases
Blood Cells, Molecules and Diseases, Elsevier, 2019, 75, pp.35-40. ⟨10.1016/j.bcmd.2018.12.004⟩
Blood Cells, Molecules and Diseases, 2019, 75, pp.35-40. ⟨10.1016/j.bcmd.2018.12.004⟩
Blood Cells, Molecules and Diseases, Elsevier, 2019, 75, pp.35-40. ⟨10.1016/j.bcmd.2018.12.004⟩
Blood Cells, Molecules and Diseases, 2019, 75, pp.35-40. ⟨10.1016/j.bcmd.2018.12.004⟩
International audience; Classical Philadelphia-negative myeloproliferative neoplasms include Polycythemia Vera (PV), Essential Thrombocythemia (ET) and Primary Myelofibrosis (PMF). They are characterized by the presence of driver mutations of JAK2, C
Autor:
Chao-Hui Yang, Cheng-Ming Hsu, I-Ya Chen, Pai-Mei Lin, Ming-Luen Hu, Ming-Yu Yang, Sheng-Fung Lin
Publikováno v:
Blood Cells, Molecules, and Diseases. 90:102577
Genomic imprinting is a form of epigenetic regulation and imprinted genes are silenced in a parental-specific manner. Imprinting is associated with various human diseases and cancers, but its roles in leukemogenesis remains elusive. In this study, th
Autor:
Misam Zawit, Ashwin Kishtagari, Valeria Visconte, Simona Pagliuca, Arda Durmaz, Hassan Awada, Carmelo Gurnari
Publikováno v:
Blood Cells, Molecules, and Diseases. 88:102549
Wilms tumor 1 (WT1) gene is commonly mutated in acute myeloid leukemia (AML), particularly in younger age population. The mechanism through which WT1 mutations drive leukemogenesis have not been fully elucidated; however, recent studies reported an a
Autor:
Elizabeth Xisto Souto, Simone Kashima, Maria Gabriela Berzoti-Coelho, Maurício Cristiano Rocha Júnior, Aline Fernanda Ferreira, Dimas Tadeu Covas, Fabíola Attié de Castro, Carlos Martínez-A, Belinda Pinto Simões, Natalia de Souza Nunes, Rodrigo Alexandre Panepucci, Mariana Tomazini Pinto
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Chronic Myeloid Leukemia (CML), Polycythemia Vera (PV), Essential Thrombocythemia (ET) and Primary Myelofibrosis (PMF) are Myeloproliferative Neoplasms (MPN) characterized by clonal myeloproliferation without cell maturation impairment. CML pathogene
Autor:
Allison Bode, Ambar Solis-Fuentes, Yuncheng Man, Umut A. Gurkan, Lalitha Nayak, Ran An, Utku Goreke, Jane A. Little, Shichen Liu, Ailis Hill, Erdem Kucukal
Publikováno v:
Blood Cells Mol Dis
Upregulated expression of P-selectin on activated endothelium and platelets significantly contributes to the initiation and progression of vaso-occlusive crises (VOC), a major cause of morbidity in sickle cell disease (SCD). Crizanlizumab (ADAKVEO®)
Autor:
Halina Antosz, Barbara Marzec-Kotarska, Anna Dmoszynska, Małgorzata Jargiełło-Baszak, Jacek Baszak, Joanna Sajewicz
Publikováno v:
Blood Cells, Molecules, and Diseases. 51:48-55
TIRAP and Myd88 are adaptor proteins for Toll-like receptors-2 and -4 (TLR2/4) which are engaged in transducing the signal to downstream molecules. Several studies have shown the increased role of infection factors in pathogenesis of B cell chronic l
Autor:
Halina Antosz, Joanna Sajewicz, Barbara Marzec-Kotarska, Małgorzata Jargiełło-Baszak, Anna Dmoszynska, Jacek Baszak
Publikováno v:
Blood Cells, Molecules, and Diseases. 49:32-40
B-cell receptor (BCR) and Toll-like receptor (TLR) stimulation and integration with signals from the pathogen or immune cells and their products determine the B-cell antibody response. Low expression of BCR is the hallmark of B lymphocytes in CLL, ho
Autor:
Jung Eun Choi, Sung-Soo Yoon, Dong Soon Lee, Myoung Hee Park, Byoung Kook Kim, Hyo Seop Ahn, Cha Ja She, Sang Mee Hwang, Hee Young Shin, Miyoung Kim
Publikováno v:
Blood Cells, Molecules, and Diseases. 47:62-66
The PAX5 is essential in normal B-cell lymphopoiesis and deregulation of PAX5 function is believed to contribute to leukemogenesis in B-ALL. We performed a comprehensive study using FISH, G-banding and IHC to identify PAX5 deletion and expression in
Publikováno v:
Blood Cells, Molecules, and Diseases. 60:1-2