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pro vyhledávání: '"Raphael Schiffmann"'
Autor:
Stefan Karlsson, Stefanie Stahl, Raphael Schiffmann, Jerrold M. Ward, Michele Cottler-Fox, Jeffrey A. Medin
Publikováno v:
Blood. 86:1218-1227
In trying to develop methods of gene therapy for Gaucher disease that will avoid the morbidity and mortality associated with bone marrow (BM) ablation, we transplanted BM stem cells transduced with a retroviral vector containing the human glucocerebr
Autor:
Licheng Xu, Raphael Schiffmann, Cynthia E. Dunbar, Stefanie Kluepfel-Stahl, Maritza Blanco, Stefan Karlsson
Publikováno v:
Europe PubMed Central
We have achieved high-efficiency gene transfer into nonmobilized peripheral blood (PB) CD34+ cells from patients with Gaucher's disease using a clinically acceptable retroviral supernatant transduction protocol. In our studies, bone marrow (BM) and P