Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Masahiro Hirakawa"'
Autor:
Robert J. Soiffer, Yusuke Kamihara, John Koreth, Rizwan Romee, Jerome Ritz, Roger Belizaire, Mahasweta Gooptu, Vincent T. Ho, Takeru Asano, Joseph H. Antin, Sarah Nikiforow, Corey Cutler, Tomohiro Kubo, Jennifer Whangbo, Masahiro Hirakawa, Hongye Liu, Edwin P. Alyea
Publikováno v:
Blood. 132:606-606
Introduction: Natural killer (NK) cells play an important role in defense against infections and cancer. Two major subsets of mature NK cells have been described. CD56bright CD16- NK cells, which normally represent only 5-10% of circulating NK cells,
Autor:
Hongye Liu, Corey Cutler, Masahiro Hirakawa, Edouard Forcade, Joseph H. Antin, Jerome Ritz, Edwin P. Alyea, Vincent T. Ho, Bruce R. Blazar, Philippe Armand, Tomohiro Kubo, Robert J. Soiffer, Yusuke Kamihara, Jennifer Whangbo, John Koreth, Sarah Nikiforow
Publikováno v:
Blood. 130:74-74
Introduction: T follicular helper (TFH) and T follicular regulatory (TFR) cells play important roles in the regulation of B-cell immunity. While TFH promote B cell functions in the germinal center (GC), TFR function as negative regulators of the GC r
Publikováno v:
Blood. 126:2357-2357
Introduction: CD4+ FoxP3+ CD25+ regulatory T cells (Treg) are required for maintenance of immune tolerance and immune homeostasis. Quantitative or functional Treg deficiency has been correlated with autoimmune disease, allergy, allograft rejection an
Autor:
Jerome Ritz, Siddha Kasar, Benjamin L. Lampson, Tiago R. Matos, Haesook T. Kim, Elizabeth A. Morgan, Jennifer R. Brown, Stacey M. Fernandes, Joshua A Fein, Masahiro Hirakawa
Publikováno v:
Blood. 126:497-497
Introduction: Idelalisib (idela) is a highly selective oral inhibitor of PI3Kδ that is currently FDA-approved in conjunction with rituximab for the treatment of relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL). In clinical trials perform
Autor:
Jennifer R. Brown, Masahiro Hirakawa, Tiago R. Matos, Siddha Kasar, Jerome Ritz, Benjamin L. Lampson, Stacey M. Fernandes
Publikováno v:
Blood. 126:1735-1735
Introduction: Idelalisib, a specific small molecule inhibitor of the delta isoform of PI3 kinase (PI3Kd), has recently been FDA approved for the treatment of relapsed CLL. Expression of PI3Kd is predominantly restricted to leukocytes, and inhibition
Autor:
Philippe Armand, Kazuyuki Murase, Jerome Ritz, Joseph H. Antin, John Koreth, Masahiro Hirakawa, Tiago R. Matos, Corey Cutler, Vincent T. Ho, Hongye Liu, Robert J. Soiffer, Edouard Forcade, Edwin P. Alyea, Jennifer Whangbo, Sarah Nikiforow
Publikováno v:
Blood. 126:919-919
Introduction: CD4+ FoxP3+ CD25+ regulatory T cells (Treg) play a central role in the maintenance of immune tolerance and prevention of chronic graft-versus-host disease (cGVHD) after allogeneic stem cell transplantation (SCT). Treg constitutively exp
Autor:
Marie J Chammas, Jerome Ritz, Eduardo Espada, Carol Reynolds, Kathy S. Wang, Kazuyuki Murase, Jennifer Whangbo, Tiago R. Matos, Edouard Forcade, Masahiro Hirakawa
Publikováno v:
Blood. 126:3425-3425
Introduction: Cytokines play important roles in the activation, proliferation, differentiation and survival of T cells. Previous studies have revealed that individual cytokines selectively activate different T cell populations and also function at sp
Autor:
Jerome Ritz, Yutaka Kawano, Haesook T. Kim, Anthony Letai, Robert J. Soiffer, John Koreth, Kazuyuki Murase, Masahiro Hirakawa, Junji Kato, Ken-ichi Matsuoka, Tiago R. Matos, Jeremy Ryan
Publikováno v:
Blood. 124:1414-1414
CD4+CD25+Foxp3+ regulatory T cells (Treg) play a critical role in establishment of immune tolerance and prevention of graft versus host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT). The recovery and maintenance of Tr