Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Erdem Goker"'
Autor:
Joseph R. Bertino, Madhu Mazumdar, Tanya M. Trippett, Richard Gorlick, Erdem Goker, Wayne F. Flintoff, Peter G. Steinherz, Yaroslav Elisseyeff
Publikováno v:
Blood. 89:1013-1018
Methotrexate (MTX) transport was examined in 27 patients with untreated acute lymphocytic leukemia (ALL) and 31 patients with relapsed ALL using a previously described fluorescent MTX analog (PT430) displacement assay (Blood 80:1158, 1992). Only 13%
Autor:
Richard J. O'Reilly, A Kheradpour, Dieter Dennig, Y Elisseyeff, Erdem Goker, Joseph R. Bertino, Catherine Jagiello, João F. Lacerda
Publikováno v:
Blood. 85:2675-2679
Impaired transport of methotrexate (MTX) is a common resistance mechanism of tumor cells to this drug. Trimetrexate (TMTX), a second-generation folate antagonist, is still active against MTX-transport-resistant cells because it enters cells by passiv
Autor:
S Schlemmer, Erdem Goker, Y Elisseyeff, Ellin Berman, Andre Rosowsky, Peter G. Steinherz, Tanya M. Trippett, M Wachter, Cuiwen Tan, JE Wright
Publikováno v:
Blood. 80:1158-1162
Although the mechanisms of resistance to methotrexate (MTX) are known in experimental tumors made resistant to this drug, little information is available regarding acquired resistance to MTX in patients. A competitive displacement assay using the flu
Autor:
Erdem Goker, Madhu Mazumdar, Peter G. Steinherz, Barbara Schnieders, Tanya M. Trippett, Ellin Berman, A Kheradpour, Mark Waltham, Cuiwen Tan, Y Elisseyeff
Publikováno v:
Blood. 86(2)
Although dihydrofolate reductase (DHFR) gene amplification is a common mechanism of resistance to methotrexate (MTX) in tumor cell lines, with the exception of a few case reports, the incidence of this phenomenon as a mechanism of MTX resistance in t