Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Alexandar Tzankov"'
Autor:
Maria-Riera Piqué-Borràs, Zivojin Jevtic, Frederik Otzen Bagger, Jonathan Seguin, Rathick Sivalingam, Matheus Filgueira Bezerra, Amber Louwaige, Sabine Juge, Ioannis Nellas, Robert Ivanek, Alexandar Tzankov, Ute Moll, Oriano Valerio Cantillo, Ramona Schulz-Heddergott, Alexandre Fagnan, Thomas Mercher, Juerg Schwaller
Publikováno v:
Blood.
The NFIA-ETO2 fusion is the product of a t(1;16)(p31;q24) chromosomal translocation so far exclusively found in pediatric patients with pure erythroid leukemia (PEL). To address the role for the pathogenesis of the disease, we expressed the NFIA-ETO2
Autor:
Rumyana Todorova, Alexandar Tzankov
Publikováno v:
Blood. 134(26)
Autor:
Juerg Schwaller, Hugues-Etienne Chatel-Soulet, Frederik Otzen Bagger, Jonathan Séguin, Alexandar Tzankov, Sabine Juge, Mineo Kurokawa
Publikováno v:
Blood. 138:2210-2210
We previously reported that transplantation of hematopoietic stem cells (HSC) expressing a doxycycline (DOX)-regulated AML-associated MLL-AF9 fusion transgene can induce an invasive and chemoresistant disease in mice formed by tumour cells that expre
Autor:
Thierry M. Nordmann, Gieri Cathomas, Thomas Daikeler, Daniel Kalbermatten, Andreas Wicki, Aino Paasinen-Sohns, Freimut D. Juengling, Alexandar Tzankov, Mike Recher, Christoph Berger
Publikováno v:
Blood
Major advances have been made in understanding the pathogenesis of Erdheim Chester disease (ECD) leading to novel treatment strategies. Targeted therapies such as BRAF inhibition have shown a significant impact on disease management emphasizing the i
Autor:
Frederik Otzen Bagger, Juerg Schwaller, Maria-Riera Piqué-Borràs, Sabine Juge, Thomas Mercher, Robert Ivanek, Amber Louwaige, Ute M. Moll, Ioannis Nellas, Ramona Schulz-Heddergott, Matheus Filgueira Bezerra, Alexandar Tzankov
Publikováno v:
Blood. 134:532-532
Pure erythroleukemia (PEL) is a very aggressive, but poorly understood form of acute myeloid leukemia characterized by malignant accumulation of erythroid progenitor cells. A novel t(1;16)(p31;q24) chromosomal translocation leading to expression of a
Autor:
Alexandar Tzankov, Wanlong Ma, Govind Bhagat, Eric D. Hsi, Ivan De Dios, Wayne Tam, Youli Zu, Maher Albitar, Maurilio Ponzoni, Michael Boe Møller, Hagop M. Kantarjian, Karen Dybkær, Miguel A. Piris, Deng Manman, Carlo Visco, Joannes H.J.M. Van Krieken, Babak Shahbaba, Ken H. Young, Andrés J.M. Ferreri, Yingjun Wang, Yong Li, Zijun Y. Xu-Monette
Publikováno v:
Albitar, M, Xu-Monette, Z Y, Shahbaba, B, De Dios, I, Wang, Y, Manman, D, Tzankov, A, Visco, C, Bhagat, G, Dybkaer, K, Tam, W, Hsi, E D, Ponzoni, M, Ferreri, A JM, Møller, M B, Piris, M A, Van Krieken, J H J M, Zu, Y, Ma, W, Kantarjian, H M, Li, Y & Young, K H 2019, ' Cell of Origin Classification of DLBCL Using Targeted NGS Expression Profiling and Deep Learning ', Blood, vol. 134, no. Suppl. 1, 2891 . https://doi.org/10.1182/blood-2019-126927
Introduction: Targeted RNA sequencing using Next Generation Sequencing (NGS) has significant advantages over transcriptome sequencing. In addition to information on mutations, fusion and alternative splicing, RNA quantification using targeted RNA seq
Autor:
Miguel A. Piris, Carlo Visco, Jane N. Winter, Youli Zu, Govind Bhagat, Xu‐Monette Y Zijun, Deng Manman, Yingjun Wang, Ivan De Dios, Maher Albitar, Michael Boe Møller, Eric D. Hsi, Maurilio Ponzoni, Han van Krieken, Karen Dybkær, Wayne Tam, Hagop M. Kantarjian, Yong Li, Alexandar Tzankov, Andrés J.M. Ferreri, Ken H. Young
Publikováno v:
Albitar, M, Xu-Monette, Z Y, Wang, Y, Manman, D, Tzankov, A, Visco, C, Bhagat, G, Dybkaer, K, Tam, W, Hsi, E D, Ponzoni, M, Ferreri, A JM, Møller, M B, Piris, M A, van Krieken, J H, De Dios, I, Zu, Y, Winter, J N, Kantarjian, H M, Li, Y & Young, K H 2019, ' MYC and BCL2 mRNA Expression As Determined By NGS Predicts Survival in DLBCL in GCB but Not in ABC Subgroup ', Blood, vol. 124, no. Suppl. 1, 5092 . https://doi.org/10.1182/blood-2019-128492
Introduction: RNA expression profiling using Next Generation Sequencing (NGS) provides important and reproducible information on expression levels of various genes. We studied the expression levels of MYC and BCL2 in patients with diffuse large B-Cel
Autor:
Youli Zu, Maher Albitar, Alexandar Tzankov, Hagop M. Kantarjian, Govind Bhagat, Ivan De Dios, Joannes H.J.M. Van Krieken, Wanlong Ma, Miguel A. Piris, Michael Boe Møller, Yong Li, Carlo Visco, Wayne Tam, Karen Dybkær, Zijun Y. Xu-Monette, Maurilio Ponzoni, Andrés J.M. Ferreri, Ken H. Young, Yingjun Wang, Eric D. Hsi, Deng Manman
Publikováno v:
Albitar, M, Xu-Monette, Z Y, Ma, W, Wang, Y, Manman, D, Tzankov, A, Visco, C, Bhagat, G, Dybkær, K, De Dios, I, Tam, W, Hsi, E D, Ponzoni, M, Ferreri, A JM, Møller, M B, Piris, M A, Van Krieken, J H J M, Zu, Y, Kantarjian, H M, Li, Y & Young, K H 2019, ' Higher Stability of Mutant mRNA As Compared to Wild-Type mRNA in Diffuse Large B-Cell Lymphoma ', Blood, vol. 134, no. Suppl. 1, pp. 1499-1499 . https://doi.org/10.1182/blood-2019-128516
Cellular RNA levels are tightly regulated by very complex nuclear and cytoplasmic processes. The regulation of mutant mRNA in cancer cells is rarely studied. We explored the effects of mutations on mRNA levels in patients with diffuse large B-cell ly
Publikováno v:
Blood. 131(20)
The sphingosine-1-phosphate receptor S1PR2 and its downstream signaling pathway are commonly silenced in diffuse large B-cell lymphoma (DLBCL), either by mutational inactivation or through negative regulation by the oncogenic transcription factor FOX
Autor:
Alexandar Tzankov, Christian Arranto
Publikováno v:
Blood. 130(5)
[Figure][1] A 68-year-old man presented with rapidly progressive dyspnea due to newly diagnosed heart failure. Cardiac magnetic resonance imaging was compatible with myocarditis. Coronary angiography showed no relevant stenosis. The endomyocardial bi