Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Jiang A"'
Autor:
Sizhou Feng, Yaojin Huang, Yapu Li, Yunhong Tian, Xiuxiu Yin, Fang Dong, Yongxin Ru, Mei Wang, Xiaowei Xie, Shangda Yang, Shihui Ma, Sha Hao, Linping Hu, Hui Cheng, Biao Zhang, Aiming Pang, Caiying Zhu, Yawen Zhang, Shulian Chen, Yawei Zheng, Wenbin Cao, Erlie Jiang, Tao Cheng
Publikováno v:
Blood
Total body irradiation (TBI) is commonly used in host conditioning regimens for human hematopoietic stem cell (HSC) transplantation to treat various hematological disorders. Exposure to TBI not only induces acute myelosuppression and immunosuppressio
Autor:
Yubin Ge, Hong Liu, Rick Li, German Novakovskiy, Jun Yan, Depei Wu, Florian Kuchenbauer, Min Chen, Katharina Rothe, Zaihui Zhang, Xiuyan Zhang, Sung-Eun Nam, Yun Zhao, Irina A Maksakova, Xiaojia Niu, Xiaoyan Jiang, Yehyeon Ahn, Arefeh Rouhi, Shenshen Lai, Wyeth W. Wasserman, Calvin K. Yip, Sarah Grasedieck, Hong Zhang
Publikováno v:
Blood. 137:3641-3655
The abundance of genetic abnormalities and phenotypic heterogeneities in acute myeloid leukemia (AML) poses significant challenges to the development of improved treatments. Here, we demonstrated that a key growth arrest-specific gene 6/AXL axis is h
Autor:
Katharina Rothe, Artem Babaian, Keith Keith Humphries, Jonathan Zeng, Xiaoyan Jiang, Min Chen, Donna L. Forrest, Hanyang Lin, Oleh Petriv, Inanc Birol, Connie J. Eaves, Jens Ruschmann, Tobias Maetzig, Ryan R. Brinkman, David J.H.F. Knapp, Naoto Nakamichi, Kieran O'Neill, Carl L. Hansen, Ryan Yen, Andrew Wu
Publikováno v:
Blood
Overcoming drug resistance and targeting cancer stem cells remain challenges for curative cancer treatment. To investigate the role of microRNAs (miRNAs) in regulating drug resistance and leukemic stem cell (LSC) fate, we performed global transcripto
Autor:
Weiqing Wei, Shuhua Cheng, Jingqi Zhou, Zijing Peng, Jiao Ma, Wenhan Wang, Yizhuo Ren, Kristy L. Richards, Kui Nie, Wayne Tam, Yitao Qi, Yajie Shen, Daiji Jiang, Jinke Cheng, Yirong Zhang, Zhengming Chen, Qiuju Fan
Publikováno v:
Blood. 139(1)
Although oncogenicity of the stem cell regulator SOX9 has been implicated in many solid tumors, its role in lymphomagenesis remains largely unknown. In this study, SOX9 was overexpressed preferentially in a subset of diffuse large B-cell lymphomas (D
Autor:
Kiyomi Morita, Koichi Takahashi, Yajian Jiang, Tianyuan Hu, Matthew C. Hill, Ayumi Kitano, Feng Wang, Xizeng Mao, Yusuke Saito, James F. Martin, Kevin A. Hoegenauer, P. Andrew Futreal, Daisuke Nakada, Kazuhiro Morishita
Publikováno v:
Blood
Oncogenic mutations confer on cells the ability to propagate indefinitely, but whether oncogenes alter the cell fate of these cells is unknown. Here, we show that the transcriptional regulator PRDM16s causes oncogenic fate conversion by transforming
Autor:
Danna Jia, Zhaohui Tang, Jingzhen Li, Tao Jiang, Xiliang Liu, Shanshan Yu, Qing Kenneth Wang, Yunqiao Han, Zhen Qu, Xuebin Hu, Shanglun Xie, Yuwen Huang, Yuexia Lv, Daji Luo, Yayun Qin, Fei Liu, Zhaojing Lu, Shanshan Han, Mugen Liu, Jiayi Tu, Yuntong Zhao
Publikováno v:
Blood. 133:805-815
Hematopoietic stem and progenitor cells (HSPCs) originate from the hemogenic endothelium via the endothelial-to-hematopoietic transition, are self-renewing, and replenish all lineages of blood cells throughout life. BCAS2 (breast carcinoma amplified
Autor:
Marta Isidro-Hernández, Verónica Domínguez, Xiaoyu Jiang, Belén Pintado, Diego Alonso-López, Yaso Natkunam, Javier Raboso-Gallego, Ana Casado-García, Carolina Vicente-Dueñas, Oscar Blanco, Shuchun Zhao, Andrew J. Gentles, Isidro Sánchez-García, Izidore S. Lossos, Javier De Las Rivas
Publikováno v:
Blood
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
Diffuse large B-cell lymphomas (DLBCLs) are clinically and genetically heterogeneous tumors. Deregulation of diverse biological processes specific to B cells, such as B-cell receptor (BCR) signaling and motility regulation, contribute to lymphomagene
Autor:
Denggang Fu, Reuben Kapur, Baskar Ramdas, Nai-Kong V. Cheung, Hua Jiang, Hong fen Guo, Alan Long, Sophie Paczesny, Maegan L. Capitano
Publikováno v:
Blood. 138:23-23
Therapies for acute myeloid leukemia (AML) has barely changed over 30 years, while treatment for other blood cancers have made remarkable leaps forward. Recent advances in genomics have allowed molecular targeted therapies (i.e. FLT3-ITD, IDH, c-KIT
Autor:
Leighton Clancy, Shafqat Inam, Emily Blyth, Wei Jiang, Adrian Gabriel Selim, Renee Simms, Gaurav Sutrave, Selmir Avdic, Elissa Atkins, Peter J. Shaw, David Gottlieb, Janine Street, Caroline M Bateman, David Ritchie, Vicki Antonenas
Publikováno v:
Blood. 138:255-255
Introduction: Reactivation of viruses such as cytomegalovirus (CMV) or Epstein Barr virus (EBV) after allogeneic hemopoietic stem cell transplant (aHSCT) is associated with increased non relapse mortality and a requirement for antivirals with mainly
Autor:
Fuhong He, Zhang Lin, Yanxun Su, Yongping Zhang, Haiyang Hu, Aili Chen, Shuting Jiang, Jun Lu, Peifang Xiao, Li Gao, Qianfei Wang, Zihan Zhou, Yixin Hu, Dan Liu, Raul C. Ribeiro, Lei Qin, Shaoyan Hu, Liyan Fan
Publikováno v:
Blood. 136:25-26
Although majority of pediatric acute myeloid leukemia (pAML) undergo complete remission (CR) after chemotherapy, more than 30% of which eventually relapse, leading to a dismal outcome. Chemo-resistant cells at CR, measured as minimal residual disease