Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Yi Zhang"'
Autor:
Matthew S. Davids, Robert J. Soiffer, Emma S. Hathaway, F. Stephen Hodi, Pavan Bachireddy, Magdalena Thurin, Vincent T. Ho, Wandi Zhang, Sarah Nikiforow, Nicoletta Cieri, Jerome Ritz, Stacey Gabriel, Mariano Severgnini, Aashna Jhaveri, X. Shirley Liu, Haesook T. Kim, Jingxin Fu, Kenneth J. Livak, Sacha Gnjatic, Scott J. Rodig, Alexandra Savell, Philippe Armand, Catherine J. Wu, Teddy Huang, Joseph H. Antin, Corey Cutler, Carrie Cibulskis, Livius Penter, Shuqiang Li, Howard Streicher, Donna Neuberg, Srinika Ranasinghe, Matthew Nazzaro, Yi Zhang, Emily M. Thrash, Helen X. Chen, John Koreth, Seunghee Kim-Schulze
Publikováno v:
Blood
Relapsed myeloid disease after allogeneic stem cell transplantation (HSCT) remains largely incurable. We previously demonstrated the potent activity of immune checkpoint blockade in this clinical setting with ipilimumab or nivolumab. To define the mo
Autor:
Ran Reshef, Tiffany Thomas, Huihui Ma, Alexandra Matschiner, Felix D Rozenberg, Rajat Bansal, David Harle, Ximi K. Wang, Markus Y. Mapara, Yi Zhang, Kirubel S Belay, Elisha Y. Pinker, Rodney J.M. Macedo Gonzales, Anne-Catrin Uhlemann, Stephen M. Lagana
Publikováno v:
Blood. 136:26-28
The gastrointestinal (GI) tract is a major target in GVHD. Conditioning-induced damage and mucosal barrier disruption are important factors in GVHD, however therapies targeting these processes have not been identified. Glucagon-like-peptide 2 (GLP-2)
Autor:
Kankan Wang, Zhu Chen, Huan Song, Yi Zhang, Yun Tan, Xiaoling Wang, Hai Fang, Wen Jin, Rongsheng Zhang, Sai-Juan Chen, Shufen Li
Publikováno v:
Blood. 137(11)
Transcriptional deregulation initiated by oncogenic fusion proteins plays a vital role in leukemia. The prevailing view is that the oncogenic fusion protein promyelocytic leukemia/retinoic acid receptor-α (PML/RARα), generated by the chromosome tra
Autor:
Li Fei, Junling Zhuang, Yan Li, Zhongxing Jiang, Feng Zhang, Yi Zhang, Huanling Zhu, Qian Jiang, Deng-Shu Wu, Xiuli Wang, Xin Du, Ze-Ping Zhou, Wei Li, ChengHao Jin, Yu Hu, Ruijuan Zhang, Jianda Hu, Jing Liu, Hu Zhou, Jinwen Huang, Jie Jin, Ruixiang Xiang, Kai Sun
Publikováno v:
Blood. 138:387-387
Myelofibrosis (MF) is associated with splenomegaly, cytopenias, constitutional symptoms, and bone marrow fibrosis, with limited therapeutic options. Currently only two Janus kinase inhibitors (JAKi) are approved for MF worldwide. Jaktinib, an oral no
Autor:
Yi Zhang
Publikováno v:
Blood
The nuclear receptor (NR) subclass, retinoid X receptors (RXRs), exert immunomodulatory functions that control inflammation and metabolism via homodimers and heterodimers, with several other NRs, including retinoic acid receptors. IRX4204 is a novel,
Publikováno v:
Blood. 136:6-7
Background: Activation of MDS1-EVI1 Complex (MECOM) via proviral insertion at its gene locus (Morishita et al., 1988) or through chromosomal rearrangements at 3q26 (Suzukawa et al., 1994; Tang et al., 2019) results in marked overexpression of EVI1, a
Autor:
Wandi Zhang, Srinika Ranasinghe, Donna Neuberg, Kenneth J. Livak, Jerome Ritz, Robert J. Soiffer, Livius Penter, Yi Zhang, Satyen H. Gohil, Shuqiang Li, Teddy Huang, Haesook T. Kim, Pavan Bachireddy, Robert Zeiser, Nicoletta Cieri, Alexandra Savell, X. Shirley Liu, Catherine J. Wu, Matthew S. Davids
Publikováno v:
Blood. 136:34-35
Relapse after allogeneic hematopoietic stem cell transplantation (HSCT) remains an unmet medical need. The ETCTN 9204 study evaluated in 71 study subjects if immune checkpoint blockade with anti-CTLA-4 (Ipilimumab (Ipi), n = 43) or anti-PD-1 (Nivolum
Autor:
Qiuying Gao, Limin Hou, Ben Niu, Yan Zheng, Xingxing Hu, Weihua Zhang, Ling Wang, Yi Wang, Zuohan Peng, Le Li, Ying Gao, Xingli Ru, Ding Zhang, Yi Zhang, Hui Wang
Publikováno v:
Blood. 136:19-20
Introduction: It has been made great clinical progresses in hematological malignancies by chimeric antigen receptor (CAR) T cell therapy which utilizes virus vector for manufacture. However, there're still issues unresolved, for instance, sophisticat
Autor:
Yuanyuan Tian, Yanyun Zhang, Min Jin, Anqi Ma, Pan Chen, Ran Reshef, Shan He, Shaoyan Hu, Changhong Li, Hongshuang Yu, Yi Zhang, Qing Tong, Yongnian Liu, Jian Jin, Elizabeth O. Hexner, Yuting Gu, Qingrong Huang, Jiefang Huang, Henry C. Fung
Publikováno v:
Blood. 129:2737-2748
Modulating T-cell alloreactivity has been a main strategy to reduce graft-versus-host disease (GVHD), a life-threatening complication after allogeneic hematopoietic stem-cell transplantation (HSCT). Genetic deletion of T-cell Ezh2, which catalyzes tr
Autor:
David L. Porter, Ximi K. Wang, Ran Reshef, Ryan H. Moy, Lee P. Richman, Austin P. Huffman, James A. Hoxie, Stephen G. Emerson, Yi Zhang, Robert H. Vonderheide, Lisa Crisalli, Rosemarie Mick
Publikováno v:
Blood. 129:906-916
Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Lymphocyte trafficking via chemokine receptors such as CCR5 plays a critical role in alloreactive respo