Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Allison Berger"'
Autor:
Akito Nakamura, Stephen Grossman, Keli Song, Kristina Xega, Yuhong Zhang, Donna Cvet, Allison Berger, Gary Shapiro, Dennis Huszar
Publikováno v:
Blood. 139(18)
Small ubiquitin-like modifier (SUMO) is a member of a ubiquitin-like protein superfamily. SUMOylation is a reversible posttranslational modification that has been implicated in the regulation of various cellular processes including inflammatory respo
Autor:
Kathryn A. Rizzo, Steven Grant, Sri Lakshmi Chalasani, Lawrence F. Povirk, Liang Zhou, Yun Dai, Mohamed Rahmani, Allison Berger, Andrea Ferreira-Gonzalez, Lihong Li, Hui Lin, Catherine I. Dumur, Yun Leng, Shuang Chen, Maciej Kmieciak, Yu Zhang
Publikováno v:
Blood. 127:2219-2230
Two classes of novel agents, NEDD8-activating enzyme (NAE) and histone deacetylase (HDAC) inhibitors, have shown single-agent activity in acute myelogenous leukemia (AML)/myelodysplastic syndrome (MDS). Here we examined mechanisms underlying interact
Autor:
Nur Bruss, Allison Berger, Cody Paiva, Stephen E. Spurgeon, Taylor Rowland, Scott R Best, Alexey V. Danilov
Publikováno v:
Blood. 132:1867-1867
Introduction: Despite the promise of B-cell receptor-associated kinase inhibitors (BCRi) in CLL, resistance to these agents is inevitable. Ubiquitin-proteasome systems are altered in cancer, leading to destabilization of tumor suppressors, overexpres
Autor:
Joseph B. Bolen, Erik Koenig, Michael Milhollen, Teresa A. Soucy, Usha Narayanan, Michael P. Thomas, James J. Garnsey, Louis M. Staudt, Mark Rolfe, Lawrence R. Dick, Tary Traore, Steven P. Langston, Julie Zhang, Jie Yu, Lenny Dang, Peter G. Smith, Allison Berger, Jennifer Adams-Duffy, Mark Manfredi
Publikováno v:
Blood. 116:1515-1523
MLN4924 is a potent and selective small molecule NEDD8-activating enzyme (NAE) inhibitor. In most cancer cells tested, inhibition of NAE leads to induction of DNA rereplication, resulting in DNA damage and cell death. However, in preclinical models o
Autor:
Stephen E. Spurgeon, Christopher George Danes, Claire Godbersen, Allison Berger, Cody Paiva, Alexey V. Danilov
Publikováno v:
Blood. 126:3994-3994
Background Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma in the U.S. DLBCL can be subdivided into the activated B-cell-like (ABC) and germinal center B-cell-like (GCB) subgroups on the basis of gene expressi
Publikováno v:
Blood. 124:4690-4690
Microenvironment-mediated upregulation of the B-cell receptor (BCR) and nuclear factor-kappaB (NFκB) signaling in the CLL cells resident in the lymph node and bone marrow promotes apoptosis evasion and clonal expansion. We recently reported that str