Zobrazeno 1 - 10
of 51
pro vyhledávání: '"35"'
Autor:
Patrizia Guglielmo, Salvatore Venuta, Fabio Stagno, Maria Pia Sormani, Alessandra Aloisi, Sandra Di Gregorio, Francesca Mannino, Rosario Giustolisi, Giuseppe Saglio, Paolo Vigneri, Paolo Bruzzi, Angelo Messina, Carlo Gambacorti-Passerini
Publikováno v:
Blood. 107(4)
The BCR-ABL oncoprotein of chronic myelogenous leukemia (CML) localizes to the cell cytoplasm, where it activates proliferative and antiapoptotic signaling pathways. We previously reported that the combination of the ABL kinase inhibitor imatinib mes
Publikováno v:
Blood. 110:3526-3531
Patients with severe immune thrombocytopenic purpura (ITP) may require an acute increase in the platelet count for surgery or ongoing hemorrhage as well as long-term maintenance treatment. Certain of these patients may be refractory to steroids, intr
Autor:
Mario Boccadoro, Fortunato Morabito, Tommaso Caravita, Giulia Benevolo, Ilaria Avonto, Norbert Pescosta, Patrizia Falco, Federica Cavallo, Vincenzo Callea, Pellegrino Musto, Clotilde Cangialosi, Antonio Palumbo, Patrizia Pregno, Maria Teresa Ambrosini, Sara Bringhen
Publikováno v:
Blood. 109:2767-2772
In multiple myeloma (MM), the addition of thalidomide or bortezomib to the standard oral melphalan/prednisone combination significantly increased response rate and event-free survival. In this multicenter phase 1/2 trial, dosing, safety, and efficacy
Autor:
Yasuhide Hayashi, Teruaki Hongo, Takanori Oda, Shin-Ichiro Nishimura, Hajime Kawasaki, Mariko Eguchi, Eiichi Ishii, Megumi Oda, Yoshiyuki Kosaka, Shigeyoshi Hibi, Ichiro Tsukimoto, Hiroji Okawa, Masue Imaizumi, Keiichi Isoyama, Naoko Kinukawa, Nanao Kamada, Takayuki Okamura, Shuki Mizutani
Publikováno v:
Blood. 98:3589-3594
This study analyzed data on 35 infants with acute myeloid leukemia (AML) who were treated with intensive chemotherapy between 1995 and 1998 in Japan. The incidence of boys, younger age (< 6 months old), and hyperleukocytosis at onset was high in pati
Publikováno v:
Blood. 84:1328-1332
One hundred forty-seven patients with hematologic diseases and treated by allogeneic marrow transplants received graft-versus-host disease (GVHD) prevention with methotrexate and cyclosporine. In addition, 73 of the 147 patients were randomized to re
Autor:
Françoise Huguet, Jacques Pris, Bernard Mazières, Bernard Fournie, Guy Laurent, Catherine Payen, Michel Laroche, Michel Attal, Daniel Schlaifer
Publikováno v:
Blood. 79:1130-1136
A trial was initiated to determine the feasibility and efficacy of a three-phase treatment including: (1) induction chemotherapy (IC); (2) high-dose melphalan with total body irradiation supported by unpurged autologous bone marrow transplantation (A
Autor:
Adrienne A. Phillips, Lucy Cook
Publikováno v:
Blood. 137:459-470
Adult T-cell leukemia/lymphoma (ATL) is a highly aggressive T-cell malignancy that arises in a proportion of individuals who are long-term carriers of human T-lymphotropic virus type 1. The median survival of aggressive subtypes is 8 to 10 months; wi
Autor:
Michel Attal, Christian Berthou, Denis Caillot, Jean-Jacques Sotto, Frédéric Maloisel, Philippe Moreau, Ibrahim Yakoub-Agha, Gerald Marit, Mamoun Dib, Mauricette Michallet, Nicolas Ketterer, Cyrille Hulin, Thierry Lamy, Jean-Luc Harousseau, Jean Bourhis, Frédéric Garban, Bernard dePrijck
Publikováno v:
Blood. 107(9)
The Intergroupe Francophone du Myélome (IFM) initiated 2 trials in 1999 to study patients with high-risk (β2-microglobulin level greater than 3 mg/L and chromosome 13 deletion at diagnosis) de novo multiple myeloma. In both protocols, the inductio
Autor:
Hans Blokzijl, Robert J. Porte, Frank W. G. Leebeek, Ton Lisman, Marieke J. H. A. Kruip, Jelle Adelmeijer, Arie P. van den Berg, Freeha Arshad, Karin Ruitenbeek, Sara C. M. Stoof
Publikováno v:
Liver International, 35(7), 1809-1815. Wiley
Liver International, 35(7), 1809-1815. Wiley-Blackwell Publishing Ltd
Liver International, 35(7), 1809-1815. Wiley-Blackwell Publishing Ltd
Rationale: Cirrhosis frequently affects multiple components of hemostasis. Reversal of the coagulopathy of these patients is frequently required in case of bleeding episodes, or as prophylaxis before invasive procedures. A simple and cost-effective w
Autor:
Ivan Horak, Raymond J. Hohl, Dawn Ange, Timothy Kottke, Scott H. Kaufmann, John J. Wright, Ivana Gojo, David W. End, Joseph D. Rosenblatt, Jane L. Liesveld, Mary Ellen Rybak, Jeffrey E. Lancet, Laxmi Narayana Buddharaju, Alain Thibault, Kees Bol, Robert T. Belly, Michael L. Tidwell, W. Edward Highsmith, Judith E. Karp
Publikováno v:
Blood. 97(11)
R115777 is a nonpeptidomimetic enzyme-specific inhibitor of farnesyl protein transferase (FT) that was developed as a potential inhibitor of Ras protein signaling, with antitumor activity in preclinical models. This study was a phase 1 trial of orall