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Publikováno v:
Blood. 136:36-37
Background Pain is a common and debilitating complication of sickle cell disease (SCD) often requiring high doses of opioids for relief. The stigma associated with pain and opioid use has made it difficult for those with SCD to obtain needed treatmen
Autor:
Nicola Gökbuget
Publikováno v:
Blood. 122:1366-1375
The treatment of older patients with acute lymphoblastic leukemia (ALL) is an unmet medical need. In Western countries, the population is aging, which means there will be an increasing number of older patients. However, in the past few decades, there
Autor:
Raj K. Patel, Vivian Auyeung, Lara N. Roberts, Julia Czuprynska, Jignesh P. Patel, Roopen Arya, Shammim Haji
Publikováno v:
Blood. 126:2335-2335
Do the safety and efficacy outcomes reported in the clinical trials of direct oral anticoagulants (DOAC) translate to the 'real-world'? Background: A number of DOACs are now available for clinicians to prescribe in clinical practice. Whilst the resul
Autor:
Andrew Palsgrove, Colleen A. McHorney, William Benton Jones, Peter C. Trask, Bhumi Trivedi, Mark A. Atkinson
Publikováno v:
Blood. 124:5967-5967
Aims: Multiple myeloma (MM) is a hematologic malignancy of plasma cells. Bone disease is a characteristic symptom of MM, and pain is one of its most distressing features. Anemia is also a common symptom and is manifested as fatigue and tiredness amon
Autor:
Suzanne R. Hayman, Shaji Kumar, Prashant Kapoor, Angela Dispenzieri, Lisa Hwa, Samith T. Kochuparambil, Martha Q. Lacy, David Dingli, Francis K. Buadi, Morie A. Gertz, Jane K. Case, Shilpa Paul, S. Vincent Rajkumar, Carrie A. Thompson, Tait D. Shanafelt
Publikováno v:
Blood. 124:2605-2605
Background: Multiple Myeloma (MM) patients have a substantially reduced Health related Quality of Life (HQOL) at diagnosis (dx) due to disease related symptoms like bone pain (58%) and fatigue (32%). HQOL monitoring is becoming increasingly important
Autor:
Muneer H. Abidi, Paul B. Jacobsen, Karen L. Syrjala, J. Douglas Rizzo, John R. Wingard, Navneet S. Majhail, Heather S.L. Jim, Nancy L. Geller, Mingwei Fei, Jennifer Le-Rademacher, Mary M. Horowitz, William A. Wood, Edward A. Faber, Stephanie J. Lee, Brent R. Logan, Juan Wu
Publikováno v:
Blood. 124:206-206
INTRODUCTION: Patient reported outcomes (PROs) including symptoms and health related quality of life (HRQOL) predict mortality in multiple cancers, such as myeloma, head and neck, lung and prostate cancer. The relationship of PROs with survival is no
Autor:
Kathleen W Wyrwich, Priscilla Auguste, Robyn von Maltzahn, Ren Yu, Sangeeta Krishnan, Nigel Dodd, Sylvia von Mackensen
Publikováno v:
Blood. 122:423-423
Hemophilia patients on prophylactic treatment can experience an improvement in health-related quality of life (HRQoL) through better protection from breakthrough bleeds and the reduction in long-term joint damage complications compared to episodic tr
Publikováno v:
Blood. 120:4704-4704
4704 Background: Acute lymphoblastic leukemia (ALL) accounts for about 20% of adult leukemias and occurs with increasing frequency in adults after 50 years of age. Symptoms include bone and joint pain, increased bruising and bleeding, weakness or tir
Publikováno v:
Blood. 118:4323-4323
Abstract 4323 BACKGROUND:Two major multicenter pediatric randomized controlled clinical trials (RCTs) in pediatric venous thromboembolism (VTE) have been conducted in the last decade, and each was closed early due to poor accrual. With the recent tre
Autor:
Janet L. Williams, Charles S. Cleeland, Jorge E. Cortes, Araceli Garcia-Gonzalez, Patricia Ault, Gary M. Mobley, Loretta A. Williams, Tito R. Mendoza
Publikováno v:
Blood. 116:3838-3838
Abstract 3838 Background: Symptom burden is the combined impact of symptoms from disease and treatment on daily functioning. Lack of symptom recognition may result in failure to address symptoms and maximize patient functioning. Patient-reported outc