Zobrazeno 1 - 10
of 1 262
pro vyhledávání: ''
Autor:
Lauren Schaff, Christian Grommes
Publikováno v:
Blood. 140:971-979
Primary central nervous system lymphoma (PCNSL) is a rare extranodal lymphomatous malignancy that affects the brain, spinal cord, leptomeninges, or vitreoretinal space, without evidence of systemic involvement. The diagnosis of PCNSL requires a high
Publikováno v:
Blood. 139:1973-1986
Disseminated intravascular coagulation (DIC) is a syndrome triggered by infectious and noninfectious pathologies characterized by excessive generation of thrombin within the vasculature and widespread proteolytic conversion of fibrinogen. Despite div
Autor:
Julio C. Chavez, James Drew, John P. Leonard, Erin Mulvey, Sonali M. Smith, Leandro Cerchietti, Nancy L. Bartlett, John L. Reagan, Jeffrey A. Jones, Ann S. LaCasce, Peter Martin, Maria Victoria Revuelta, Chengqing Wu
Publikováno v:
Blood. 139:1147-1159
Resistance to standard immunochemotherapy remains an unmet challenge in diffuse large B-cell lymphoma (DLBCL), and aberrant DNA methylation may contribute to chemoresistance. Promising early-phase results were reported with rituximab, cyclophosphamid
Autor:
Hiroshi Imanaga, Tatsuya Terasaki, Koichi Akashi, Kensuke Sasaki, Fumihiko Nakao, Takeshi Inukai, Jumpei Nogami, Takahiro Maeda, Els Verhoeyen, Takuji Yamauchi, Koshi Akahane, Yuichiro Semba
Publikováno v:
Blood
Acute lymphoblastic leukemia (ALL) harboring the IgH-CRLF2 rearrangement (IgH-CRLF2-r) exhibits poor clinical outcomes and is the most common subtype of Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL). While multiple chemother
Autor:
Dan Guo, Wenqi Zhu, Qian Ren, Tao Cheng, Peiwen Zhang, Nan Wang, Jing Yin, Yangyang Zhao, Na You, Xiao-Tong Ma
Publikováno v:
Blood. 138:464-479
Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy for which there is an unmet need for novel treatment strategies. Here, we characterize the growth arrest and DNA damage-inducible gene gamma (GADD45g) as a novel tumor suppressor
Autor:
Panpan Han, Jun Peng, Guosheng Li, Yu Hou, Yang Liu, Haoyi Wang, Yunqi Sun, Tianshu Yu, Hai Zhou, Ming Hou, Xinguang Liu, Lizhen Li, Yajing Zhao, Pengcheng Xu, Xiang Hu, Tao Sun
Publikováno v:
Blood. 138:674-688
Our previous clinical study showed that low-dose decitabine exhibited sustained responses in nearly half of patients with refractory immune thrombocytopenia (ITP). The long-term efficacy of decitabine in ITP is not likely due to its simple role in in
Autor:
Mayumi Sugita, Kimihito Cojin Kawabata, Martin Carroll, Sarah Wyman, Bas J. Wouters, Zhengming Chen, Michael Albert, Winnie Yip, Cem Meydan, Srinjoy Goswami, Hongliang Zong, Ruud Delwel, Ari Melnick, Gail J. Roboz, Monica L. Guzman, Christopher E. Mason
Publikováno v:
Blood, 137(6), 812-825. American Society of Hematology
Blood
Blood
B-cell lymphoma 6 (BCL6) is a transcription repressor and proto-oncogene that plays a crucial role in the innate and adaptive immune system and lymphoid neoplasms. However, its role in myeloid malignancies remains unclear. Here, we explored the role
Autor:
Adrienne A. Phillips, Lucy Cook
Publikováno v:
Blood. 137:459-470
Adult T-cell leukemia/lymphoma (ATL) is a highly aggressive T-cell malignancy that arises in a proportion of individuals who are long-term carriers of human T-lymphotropic virus type 1. The median survival of aggressive subtypes is 8 to 10 months; wi
Autor:
Kate Nesbitt, Min Du, Simon T. Abrams, Cheng Hock Toh, Yasmina M. E. Sahraoui, Guozheng Wang, Jonathan H. Foley, Micaela Harrasser, David Lillicrap, Ziqi Lin, Dunhao Su, Zhenxing Cheng, Yasir Alhamdi
Publikováno v:
BLOOD
Thrombin generation is pivotal to both physiological blood clot formation and pathological development of disseminated intravascular coagulation (DIC). In critical illness, extensive cell damage can release histones into the circulation, which can in
Autor:
Jaclyn Garza Grenier, R. Coleman Lindsley, Corey Cutler, Wael Saber, Mikko Myllymäki, Zhen-Huan Hu, Donna Neuberg, Christopher R. Reilly, Stephen R. Spellman, Esther H. Orr, Immaculata De Vivo, Joseph H. Antin, Tao Wang, Christopher J. Gibson, Maxine M. Chen, David P. Steensma, Robert A. Redd, Suneet Agarwal
Publikováno v:
Blood
Allogeneic hematopoietic stem cell transplantation is the only potentially curative treatment for patients with myelodysplastic syndrome (MDS), but long-term survival is limited by the risk of transplant-related complications. Short telomere length,